Výsledky vyhledávání - "Matthew P. Mount"

Perturbation of Transcription Factor Nur77 Expression Mediated by Myocyte Enhancer Factor 2D (MEF2D) Regulates Dopaminergic Neuron Loss in Response to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Autor: David S. Park, Matthew P. Mount, Steve M. Callaghan, Mandana Amini, Jerzy Kulczycki, Zixu Mao, Yi Zhang, Ruth S. Slack, Hymie Anisman

Publikováno v: Journal of Biological Chemistry. 288:14362-14371

We have earlier reported the critical nature of calpain-CDK5-MEF2 signaling in governing dopaminergic neuronal loss in vivo. CDK5 mediates phosphorylation of the neuronal survival factor myocyte enhancer factor 2 (MEF2) leading to its inactivation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce092aa30817ca34a67ae86697d6413
https://doi.org/10.1074/jbc.m112.439216

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Involvement of Interferon-γ in Microglial-Mediated Loss of Dopaminergic Neurons

Autor: Patrice D. Smith, Sylvie Faucher, Shawn Hayley, Ruth S. Slack, Hymie Anisman, Matthew P. Mount, Arman Lira, David S. Park, David Grimes

Publikováno v: The Journal of Neuroscience. 27:3328-3337

Growing evidence implicates microglia in the loss of dopaminergic neurons in Parkinson's disease (PD). However, factors mediating microglial activation in PD are poorly understood. Proinflammatory cytokines, such as interferon-γ (IFN-γ), orchestrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f618098f883555252e72df6d7ad775c5
https://doi.org/10.1523/jneurosci.5321-06.2007

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Calpain-Regulated p35/cdk5 Plays a Central Role in Dopaminergic Neuron Death through Modulation of the Transcription Factor Myocyte Enhancer Factor 2

Autor: Xuemin Wang, Patrice D. Smith, Hymie Anisman, Inez Vincent, Raj Shree, Matthew P. Mount, Ruth S. Slack, David S. Park, Steve M. Callaghan, Zixu Mao

Publikováno v: The Journal of Neuroscience. 26:440-447

The mechanisms underlying dopamine neuron loss in Parkinson's disease (PD) are not clearly defined. Here, we delineate a pathway by which dopaminergic loss induced by 1-methyl-4-phenyl 1,2,3,6 tetrahydropyridine (MPTP) is controlledin vivo. We report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fbe32dd5c7ad4ae32fdff577f96cb1
https://doi.org/10.1523/jneurosci.2875-05.2006

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Regulation of Dopaminergic Loss by Fas in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease

Autor: David S. Park, Shawn Hayley, Patrice D. Smith, Matthew P. Mount, Stephen J. Crocker, Serge Przedborski, Hymie Anisman, Tanaya Shree, Ruth S. Slack, Vernice Jackson-Lewis

Publikováno v: The Journal of Neuroscience. 24:2045-2053

Accumulating evidence suggests that apoptotic and inflammatory factors contribute to the demise of dopaminergic neurons. In this respect, Fas, a member of the tumor necrosis factor receptor family with proapoptotic and inflammatory functions, was rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff756daeb23ec5bae22b8ad5dee9764c
https://doi.org/10.1523/jneurosci.4564-03.2004

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Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

Autor: Steven M. Callaghan, Serge Przedborski, Hymie Anisman, Kelly L. Jordan-Sciutto, Patrice D. Smith, Ruth S. Slack, Vernice Jackson-Lewis, David S. Park, Shawn Hayley, Stephen J. Crocker, Matthew P. Mount, Michael J. O'Hare

Publikováno v: Proceedings of the National Academy of Sciences. 100:13650-13655

Recent evidence indicates that cyclin-dependent kinases (CDKs, cdks) may be inappropriately activated in several neurodegenerative conditions. Here, we report that cdk5 expression and activity are elevated after administration of 1-methyl-4-phenyl-1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d579bec232be1405ae8111beed24a0c3
https://doi.org/10.1073/pnas.2232515100

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Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1

Autor: Valerie A. Wallace, Jie Shen, Chantal Mazerolle, Ruth S. Slack, M. Emdadul Haque, David S. Park, Hymie Anisman, Steve M. Callaghan, Matthew P. Mount, Tohru Kitada, Elizabeth Abdel-Messih, Farzaneh Safarpour

Publikováno v: The Journal of biological chemistry. 287(27)

Mutations in the mitochondrial PTEN-induced kinase 1 (Pink1) gene have been linked to Parkinson disease (PD). Recent reports including our own indicated that ectopic Pink1 expression is protective against toxic insult in vitro, suggesting a potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b5f3a42bc402ab511d84e6fecf3631
https://pubmed.ncbi.nlm.nih.gov/22511790

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Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase

Autor: Wiplove R. Lamba, Patrice D. Smith, Shawn P. Hayley, Stephen J. Crocker, Matthew P. Mount, Ruth S. Slack, David S. Park, Steven M. Callaghan

Publikováno v: Journal of neurochemistry. 96(2)

Mechanical transection of the nigrostriatal dopamine pathway at the medial forebrain bundle (MFB) results in the delayed degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). We have previously demonstrated that c-Jun act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a637258116005d7289707b839391de82
https://pubmed.ncbi.nlm.nih.gov/16336220

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

Autor: Hossein Aleyasin, David Westaway, Scott Pownall, Patrick Horne, Matthew P. Mount, Patrice D. Smith, Andrew Wakeham, Shawn Hayley, David S. Park, Raymond H. Kim, Suneil K. Kalia, Annick J. You-Ten, Tak W. Mak, Hymie Anisman, Andres M. Lozano

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 102(14)

Mutations of the DJ-1 (PARK7) gene are linked to familial Parkinson's disease. We used gene targeting to generate DJ-1-deficient mice that were viable, fertile, and showed no gross anatomical or neuronal abnormalities. Dopaminergic neuron numbers in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db4502bf3863cd4b590313ff1e5cc92
https://pubmed.ncbi.nlm.nih.gov/15784737

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