Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Matthew P. Lech"'
Autor:
Rebeccah J. Luu, B. Christopher Hoefler, Ashley L. Gard, Casey R. Ritenour, Miles T. Rogers, Ernest S. Kim, Jonathan R. Coppeta, Brian P. Cain, Brett C. Isenberg, Hesham Azizgolshani, Oscar R. Fajardo-Ramirez, Guillermo García-Cardeña, Matthew P. Lech, Lindsay Tomlinson, Joseph L. Charest, Corin Williams
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Background: Tissue fibrosis is a major healthcare burden that affects various organs in the body for which no effective treatments exist. An underlying, emerging theme across organs and tissue types at early stages of fibrosis is the activation of pe
Externí odkaz:
https://doaj.org/article/8223c1e9f8d84ea8861ab8c9956e14d2
Autor:
Miles T. Rogers, Ashley L. Gard, Robert Gaibler, Thomas J. Mulhern, Rivka Strelnikov, Hesham Azizgolshani, Brian P. Cain, Brett C. Isenberg, Nerses J. Haroutunian, Nicole E. Raustad, Philip M. Keegan, Matthew P. Lech, Lindsay Tomlinson, Jeffrey T. Borenstein, Joseph L. Charest, Corin Williams
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Microphysiological organ-on-chip models offer the potential to improve the prediction of drug safety and efficacy through recapitulation of human physiological responses. The importance of including multiple cell types within tissue models h
Externí odkaz:
https://doaj.org/article/8cf0ffca17424706a726f4770e2e96bd
Autor:
Trenton T. Ross, Collin Crowley, Kenneth L. Kelly, Anthony Rinaldi, David A. Beebe, Matthew P. Lech, Robert V. Martinez, Santos Carvajal-Gonzalez, Magalie Boucher, Dinesh Hirenallur-Shanthappa, Jeffrey Morin, Alan C. Opsahl, Sarah R. Vargas, Kendra K. Bence, Jeffrey A. Pfefferkorn, William P. Esler
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 829-851 (2020)
Background & Aims: Disordered metabolism, steatosis, hepatic inflammation, and fibrosis contribute to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl-CoA carboxylase (ACC) catalyzes the first committed step in de novo lipogenesis (DNL
Externí odkaz:
https://doaj.org/article/beb0f489c5c840ed83b968a320f69c68
Autor:
Anthony P. Napolitano, Dylan M. Dean, Alan J. Man, Jacquelyn Youssef, Don N. Ho, Adam P. Rago, Matthew P. Lech, Jeffrey R. Morgan
Publikováno v:
BioTechniques, Vol 43, Iss 4, Pp 494-500 (2007)
Techniques that allow cells to self-assemble into three-dimensional (3-D) spheroid microtissues provide powerful in vitro models that are becoming increasingly popular—especially in fields such as stem cell research, tissue engineering, and cancer
Externí odkaz:
https://doaj.org/article/c49be048f604407fb1e699e2f295a1d8
Autor:
Thomas Fabre, Alexander M. S. Barron, Stephen M. Christensen, Shoh Asano, Kathryn Bound, Matthew P. Lech, Marc H. Wadsworth, Xiao Chen, Chang Wang, Ju Wang, James McMahon, Franklin Schlerman, Alexis White, Kellie M. Kravarik, Andrew J. Fisher, Lee A. Borthwick, Kevin M. Hart, Neil C. Henderson, Thomas A. Wynn, Ken Dower
Publikováno v:
Science Immunology. 8
Macrophages are central orchestrators of the tissue response to injury, with distinct macrophage activation states playing key roles in fibrosis progression and resolution. Identifying key macrophage populations found in human fibrotic tissues could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e76eb49e1c9fb0e9ca8eabe33a316fa9
https://doi.org/10.1126/sciimmunol.add8945
https://doi.org/10.1126/sciimmunol.add8945
Autor:
Robert Gaibler, Miles Rogers, Corin Williams, Rivka Strelnikov, Hesham Azizgolshani, Nerses J. Haroutunian, Ashley L. Gard, Lindsay Tomlinson, Matthew P. Lech, Philip M. Keegan, Brett C. Isenberg, B P Cain, Nicole E. Raustad, Jeffrey T. Borenstein, Joseph L. Charest, T J Mulhern
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Microphysiological organ-on-chip models offer the potential to improve the prediction of drug safety and efficacy through recapitulation of human physiological responses. The importance of including multiple cell types within tissue models has been w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e7982bcf40fc8a1d3759f70ee9785f
https://doaj.org/article/8cf0ffca17424706a726f4770e2e96bd
https://doaj.org/article/8cf0ffca17424706a726f4770e2e96bd
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems
Autor:
Magalie Boucher, William P. Esler, Santos Carvajal-Gonzalez, David A. Beebe, Alan C. Opsahl, Trenton T. Ross, Jeffrey A. Pfefferkorn, Sarah R. Vargas, Anthony Rinaldi, Matthew P. Lech, Collin Crowley, Kendra K. Bence, Jeffrey Morin, Kenneth L. Kelly, Robert V. Martinez, Dinesh Hirenallur-Shanthappa
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 829-851 (2020)
Background & Aims Disordered metabolism, steatosis, hepatic inflammation, and fibrosis contribute to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl-CoA carboxylase (ACC) catalyzes the first committed step in de novo lipogenesis (DNL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6cb8bf59bc09c5b2d3cae69055728d
https://doi.org/10.1016/j.jcmgh.2020.06.001
https://doi.org/10.1016/j.jcmgh.2020.06.001
Autor:
T J Mulhern, Ashley L. Gard, Brett C. Isenberg, Ernest S. Kim, Kelly Tan, Vishal Tandon, Shyam Sundhar Bale, Miles Rogers, Jonathan R. Coppeta, J C de Souza, B C Hoefler, A Zorn, K B Baldwin, E L Wiellette, Else M. Vedula, Matthew P. Lech, Joseph L. Charest, Louis B. Kratchman, A Patterson, Philip M. Keegan, Hesham Azizgolshani, Nerses J. Haroutunian, E E Marr, S H Kann, Corin Williams, B P Cain, R J Luu, T A Petrie
Publikováno v:
Lab on a chip. 21(8)
Drug development suffers from a lack of predictive and human-relevant in vitro models. Organ-on-chip (OOC) technology provides advanced culture capabilities to generate physiologically appropriate, human-based tissue in vitro, therefore providing a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0a71b425453dd13b6fdb6d5d297338
https://pubmed.ncbi.nlm.nih.gov/33881130
https://pubmed.ncbi.nlm.nih.gov/33881130
Autor:
Marion T. Kasaian, A. David Rodrigues, Regis Doyonnas, Bhagwat Prasad, Aarti Sawant-Basak, Matthew P. Lech, Nikolaos Tsamandouras
Publikováno v:
Drug Metabolism and Disposition. 46:1581-1587
Intestinal disposition of small molecules involves interplay of drug metabolizing enzymes (DMEs), transporters, and host-microbiome interactions, which has spurred the development of in vitro intestinal models derived from primary tissue sources. Suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464ef4e1f658fa92c87a9b63b21bd5a0
https://doi.org/10.1124/dmd.118.082784
https://doi.org/10.1124/dmd.118.082784
Autor:
Baohong Zhang, Franklin J. Schlerman, Matthew P. Lech, Leigh Savary, Morten A. Karsdal, Bruce L. Homer, Thomas P. Brown, Gabriela Campanholle, Ju Wang, Ken Dower, Qing Nie, Germaine Boucher, Shanrong Zhao, Bryce G. Johnson, Federica Genovese, Li Xi, Yutian Zhan, Robert V. Martinez, Vuong Nguyen
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181861 (2017)
PLoS ONE
PLoS ONE
ZSF1 rats exhibit spontaneous nephropathy secondary to obesity, hypertension, and diabetes, and have gained interest as a model system with potentially high translational value to progressive human disease. To thoroughly characterize this model, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e277265c5cbe0c5ccea9b86987f25e0
http://europepmc.org/articles/PMC5529026?pdf=render
http://europepmc.org/articles/PMC5529026?pdf=render