Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Matthew P. Hardy"'
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1522 (2023)
Human complement receptor 1 (CR1) is a membrane-bound regulator of complement that has been the subject of recent attempts to generate soluble therapeutic compounds comprising different fragments of its extracellular domain. This review will focus on
Externí odkaz:
https://doaj.org/article/84acee268c14478fac815f3d72112852
Autor:
Anjan K. Bongoni, Ingela B. Vikstrom, Jennifer L. McRae, Evelyn J. Salvaris, Nella Fisicaro, Martin J. Pearse, Sandra Wymann, Tony Rowe, Adriana Baz Morelli, Matthew P. Hardy, Peter J. Cowan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The complement system is a potent mediator of ischemia–reperfusion injury (IRI), which detrimentally affects the function and survival of transplanted kidneys. Human complement receptor 1 (HuCR1) is an integral membrane protein that inhibi
Externí odkaz:
https://doaj.org/article/6759be9e51d64710ba80a5394b27e1b6
Autor:
If H. A. Barnes, Ximena Ibarra-Soria, Stephen Fitzgerald, Jose M. Gonzalez, Claire Davidson, Matthew P. Hardy, Deepa Manthravadi, Laura Van Gerven, Mark Jorissen, Zhen Zeng, Mona Khan, Peter Mombaerts, Jennifer Harrow, Darren W. Logan, Adam Frankish
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Olfactory receptor (OR) genes are the largest multi-gene family in the mammalian genome, with 874 in human and 1483 loci in mouse (including pseudogenes). The expansion of the OR gene repertoire has occurred through numerous dupli
Externí odkaz:
https://doaj.org/article/3233a58fa54941809c8aafda7df194f7
Autor:
Christian A. Schaer, Catherine Owczarek, Jeremy W. Deuel, Stefan Schauer, Jin Hyen Baek, Ayla Yalamanoglu, Matthew P. Hardy, Pierre D. Scotney, Peter M. Schmidt, Matthias Pelzing, Peter Soupourmas, Paul W. Buehler, Dominik J. Schaer
Publikováno v:
BMC Biotechnology, Vol 18, Iss 1, Pp 1-13 (2018)
Abstract Background Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to attenuate toxic effects of cell-free hemoglobin (Hb). Proof of concept studies have demonstrated efficacy of Hp in h
Externí odkaz:
https://doaj.org/article/113428394a1c4d0a8ad57a180d988969
Autor:
Sophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Winnie L. Kan, Emma F. Barry, Mara Dottore, Karen S. Cheung Tung Shing, Craig J. Morton, Urmi Dhagat, Matthew P. Hardy, Nicholas J. Wilson, Matthew T. Downton, Christine Schieber, Timothy P. Hughes, Angel F. Lopez, Michael W. Parker
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The N-terminal domain (NTD) of interleukin-3 receptor α-subunit (IL3Rα) is involved in IL-3 recognition but the underlying mechanism is unknown. Here, the authors present crystal structures of the IL3Rα complex and provide biochemical evidence tha
Externí odkaz:
https://doaj.org/article/a177e8976263487282e8d1895527256b
Autor:
Sophie E. Broughton, Timothy R. Hercus, Matthew P. Hardy, Barbara J. McClure, Tracy L. Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F. Barry, Winnie L. Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J. Busfield, Catherine M. Owczarek, Andrew D. Nash, Nicholas J. Wilson, Michael W. Parker, Angel F. Lopez
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 410-419 (2014)
Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the crystal structure of the IL-3 receptor α chain (IL3Rα) in complex with the anti-leukemia
Externí odkaz:
https://doaj.org/article/06924e2c5a1a4bf8928942626539913b
Autor:
Stephanie Trezise, Alexander Karnowski, Pasquale L. Fedele, Sridurga Mithraprabhu, Yang Liao, Kathy D’Costa, Andrew J. Kueh, Matthew P. Hardy, Catherine M. Owczarek, Marco J. Herold, Andrew Spencer, Wei Shi, Simon N. Willis, Stephen L. Nutt, Lynn M. Corcoran
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2161 (2018)
Antibody Secreting Cells (ASCs) are a fundamental component of humoral immunity, however, deregulated or excessive antibody production contributes to the pathology of autoimmune diseases, while transformation of ASCs results in the malignancy Multipl
Externí odkaz:
https://doaj.org/article/9cde6506001f4bd4b27c3ae2b39d4361
Publikováno v:
Journal of Immunological Sciences. 6:1-17
Human Complement Receptor 1 (CR1/CD35) is a potent negative regulator of the complement system. Its mechanism of action is through interaction with the complement activation fragments, C3b and C4b to mediate decay acceleration of the C3 and C5 conver
Autor:
Anton Zalewski, Arna Andrews, Isabelle Glauser, Marcel Mischnik, Matthew P. Hardy, Anne M Verhagen, Kerstin Emmrich, Sabine Pestel, Con Panousis, Philipp Claar, Victor Turnbull, Chao-Guang Chen, Michael J. Wilson, Gregory T. Bass, Elmar Raquet, Steve K. Dower, Jenny Chia, Thomas Weimer, Vesna Tomasetig
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:2710-2725
BACKGROUND We have recently reported on a recombinant von Willebrand factor (VWF) D'D3 albumin fusion protein (rD'D3-FP) developed to extend the half-life of coagulation factor VIII (FVIII) for the treatment of hemophilia A. Based on predictive model
Autor:
Sandra Wymann, Marcel Mischnik, David Leong, Subhajit Ghosh, Xiahui Tan, Helen Cao, Benjamin Kuehnemuth, Glenn A. Powers, Partho Halder, Mitchell J. de Souza, Hannah S. James, Vesna Tomasetig, Holger Lind, Paolo Rossato, Catherine M. Owczarek, Saw Yen Ow, Steven K. Dower, Adriana Baz Morelli, Tony Rowe, Matthew P. Hardy
Publikováno v:
The Biochemical journal. 479(9)
Human Complement Receptor 1 (HuCR1) is a potent membrane-bound regulator of complement both in vitro and in vivo, acting via interaction with its ligands C3b and C4b. Soluble versions of HuCR1 have been described such as TP10, the recombinant full-le