Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Matthew P. Challis"'
Autor:
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren J Creek
Publikováno v:
eLife, Vol 13 (2024)
New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of Plasmodium M1 alanyl metalloaminopeptidase as an attractive drug target usin
Externí odkaz:
https://doaj.org/article/332f337244e8411285174e5b2343498f
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 20, Iss , Pp 135-144 (2022)
New antimalarial compounds with novel mechanisms of action are urgently needed to combat the recent rise in antimalarial drug resistance. Phenotypic high-throughput screens have proven to be a successful method for identifying new compounds, however,
Externí odkaz:
https://doaj.org/article/80c228a22fa7455bb8385efef7f26dce
Autor:
Peter J. Scammells, Darren J. Creek, Vicky M. Avery, Raymond S. Norton, Shane M. Devine, Ghizal Siddiqui, Matthew P. Challis, Jomo K. Kigotho, Amanda De Paoli, Christopher A. MacRaild
Publikováno v:
European journal of medicinal chemistry. 221
The emergence of Plasmodium falciparum resistance to frontline antimalarials, including artemisinin combination therapies, highlights the need for new molecules that act via novel mechanisms of action. Herein, we report the design, synthesis and anti
Autor:
Geoffrey W. Birrell, Gavin D. Heffernan, Darren J. Creek, Dovile Anderson, David P. Jacobus, Michael D. Edstein, Amanda De Paoli, Matthew P. Challis, Shane M. Devine, Ghizal Siddiqui
Publikováno v:
Mol Cell Proteomics
The increasing incidence of antimalarial drug resistance to the first-line artemisinin combination therapies underpins an urgent need for new antimalarial drugs, ideally with a novel mode of action. The recently developed 2-aminomethylphenol, JPC-321
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f4517c06ea1d074815e2ba4e7aacb1
https://europepmc.org/articles/PMC7000111/
https://europepmc.org/articles/PMC7000111/
Autor:
Giannangelo, Carlo, Challis, Matthew P., Siddiqui, Ghizal, Edgar, Rebecca, Malcolm, Tess R., Webb, Chaille T., Drinkwater, Nyssa, Vinh, Natalie, Macraild, Christopher, Counihan, Natalie, Duffy, Sandra, Wittlin, Sergio, Devine, Shane M., Avery, Vicky M., De Koning-Ward, Tania, Scammells, Peter, McGowan, Sheena, Creek, Darren J.
Publikováno v:
eLife; 7/8/2024, p1-32, 32p
Publikováno v:
Zika & Mosquito Week; 7/26/2024, p1547-1547, 1p