Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Matthew P. Glenn"'
Autor:
Mark F. Jacobs, Matthew P. Glenn, Matthew J. McGrath, Hesheng Zhang, Ian Brereton, William Kitching
Publikováno v:
ARKIVOC, Vol 2001, Iss 7, Pp 114-137 (2001)
Externí odkaz:
https://doaj.org/article/b4e653b91a174b90947dd54304600b1b
Autor:
Sung Youn Chang, Lorena S. Beese, Matthew P. Glenn, Said M. Sebti, Michael A. Hast, Ryan J. Floyd, Erin Pusateri Keaney, William P. Katt, Christopher G. Cummings, Andrew D. Hamilton, Michael H. Gelb, Steven Fletcher, Cynthia Bucher, Wesley C. Van Voorhis, Michelle A. Blaskovich
Publikováno v:
Journal of Medicinal Chemistry. 53:6867-6888
A potent class of anticancer, human farnesyltransferase (hFTase) inhibitors has been identified by “piggy-backing” on potent, antimalarial inhibitors of Plasmodium falciparum farnesyltransferase (PfFTase). On the basis of a 4-fold substituted eth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21318648da4f197cdb66a03371cc123e
https://doi.org/10.1021/jm1001748
https://doi.org/10.1021/jm1001748
Autor:
Matthew P. Glenn, Sang Hoon Lee, Said M. Sebti, Andrew D. Hamilton, Katherine J. Kayser-Bricker, Jin Q. Cheng
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:1764-1771
Akt has emerged as a critical target for the development of anti-cancer therapies. It has been found to be amplified, overexpressed, or constitutively activated in numerous human malignancies with oncogenesis derived from the simultaneous promotion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481c148b2f48b80dbc5e7aa7993ac8a0
https://doi.org/10.1016/j.bmc.2008.09.058
https://doi.org/10.1016/j.bmc.2008.09.058
Autor:
Frederick S. Buckner, Kohei Yokoyama, Saïd M. Sebti, Oliver Hucke, Carrie Hornéy, Prakash Rao Pendyala, Sung Youn Chang, Kasey Rivas, Wesley C. Van Voorhis, Debopam Chakrabarti, Christophe L. M. J. Verlinde, Michael H. Gelb, Matthew P. Glenn, Andrew D. Hamilton
Publikováno v:
Angewandte Chemie. 117:4981-4984
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e9748ee85f330b607a4cf6f0dbe1a0
https://doi.org/10.1002/ange.200500674
https://doi.org/10.1002/ange.200500674
Autor:
Matthew P. Glenn, Karl A. Hansford, Pia Kahnberg, Glen M. Boyle, David P. Fairlie, Dhiraj Hans, Peter G. Parsons, Adam C. Martyn
Publikováno v:
Journal of Medicinal Chemistry. 47:2984-2994
Selective destruction of malignant tumor cells without damaging normal cells is an important goal for cancer chemotherapy in the 21st century. Differentiating agents that transform cancer cells to either a nonproliferating or normal phenotype could p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d752416fc4ec0d9810d1f24e0b0b395c
https://doi.org/10.1021/jm030222i
https://doi.org/10.1021/jm030222i
Autor:
David P. Fairlie, Matthew P. Glenn
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 2:433-445
Bioactive structures of peptides represent important clues for drug discovery and development although peptides themselves have substantial limitations as drugs. One promising approach to overcoming the limitations of peptides is to progressively rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef77b308e30b30811717ac8440c6ab52
https://doi.org/10.2174/1389557023405747
https://doi.org/10.2174/1389557023405747
Autor:
Robert Reid, Christopher J. Birch, David P. Tyssen, Joel Da Tyndall, David P. Fairlie, Matthew P. Glenn, Leonard Keith Pattenden
Publikováno v:
Journal of Medicinal Chemistry. 45:371-381
New amino acids are reported in which component macrocycles are constrained to mimic tripeptides locked in a beta-strand conformation. The novel amino acids involve macrocycles functionalized with both an N- and a C-terminus enabling addition of appe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901492fb61a1ee76b3413a8b88e68e43
https://doi.org/10.1021/jm010414i
https://doi.org/10.1021/jm010414i
Autor:
John D. Cotton, William Kitching, Colin H. L. Kennard, KA Byriel, Bruce H. Riches, Matthew P. Glenn, Anthony C. Willis, Jean-Marie Rosset
Publikováno v:
Organometallics. 17:1968-1983
The dimeric eta(3)-allylpalladium chloride complexes formed from various cycloalkenes (C-7-C-13) and some methyl-and tert-butyl-substituted cycle alkenes have be en characterized by H-1 and C-13 NMR spectroscopy and in selected cases by X-ray crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d56c2c02cd2986a6ccbbabf7fbf11d9
https://doi.org/10.1021/om971132c
https://doi.org/10.1021/om971132c
Autor:
Natasha L. Hungerford, Soo Gyeong Cho, Matthew P. Glenn, Douglas J. Brecknell, Roberto Nunez, Frank K. Cartledge, William Kitching, Rayomand J. Unwalla, Lynette K. Lambert, Bruce H. Riches
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :1365-1368
Molecular mechanics calculations (MM3-92) suggest that a slightly distorted diaxial chair conformation of trans-1,2-bis(trimethylsilyl)cyclohexane is at least 1.26 kcal mol-1 (1 cal = 4.184 J) lower in steric energy than the diequatorial form, and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48c59cbb491f29acb69ec7816d4ad40c
https://doi.org/10.1039/a607563k
https://doi.org/10.1039/a607563k
Publikováno v:
ChemInform. 31
Deuterium labelling and 2H NMR mapping demonstrate that cyclooctyl and cyclodecyl mesylates in aqueous EtOH exhibit greatly enhanced or exclusive levels of 1,5-hydride shift, provided a Me3Sn group is β to the migrating hydrogen, and after tin group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de8c73291e59997624eaa7bae487b977
https://doi.org/10.1002/chin.200023080
https://doi.org/10.1002/chin.200023080