Zobrazeno 1 - 10
of 476
pro vyhledávání: '"Matthew P Frosch"'
Autor:
Harshvardhan Gazula, Henry FJ Tregidgo, Benjamin Billot, Yael Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse, Lucas J Deden-Binder, Adria Casamitjana, Erica J Melief, Caitlin S Latimer, Mitchell D Kilgore, Mark Montine, Eleanor Robinson, Emily Blackburn, Michael S Marshall, Theresa R Connors, Derek H Oakley, Matthew P Frosch, Sean I Young, Koen Van Leemput, Adrian V Dalca, Bruce Fischl, Christine L MacDonald, C Dirk Keene, Bradley T Hyman, Juan E Iglesias
Publikováno v:
eLife, Vol 12 (2024)
We present open-source tools for three-dimensional (3D) analysis of photographs of dissected slices of human brains, which are routinely acquired in brain banks but seldom used for quantitative analysis. Our tools can: (1) 3D reconstruct a volume fro
Externí odkaz:
https://doaj.org/article/bee5031ed3ac4569bd31db0c5630fc96
Autor:
Gary W Beecham, Kara Hamilton, Adam C Naj, Eden R Martin, Matt Huentelman, Amanda J Myers, Jason J Corneveaux, John Hardy, Jean-Paul Vonsattel, Steven G Younkin, David A Bennett, Philip L De Jager, Eric B Larson, Paul K Crane, M Ilyas Kamboh, Julia K Kofler, Deborah C Mash, Linda Duque, John R Gilbert, Harry Gwirtsman, Joseph D Buxbaum, Patricia Kramer, Dennis W Dickson, Lindsay A Farrer, Matthew P Frosch, Bernardino Ghetti, Jonathan L Haines, Bradley T Hyman, Walter A Kukull, Richard P Mayeux, Margaret A Pericak-Vance, Julie A Schneider, John Q Trojanowski, Eric M Reiman, Alzheimer's Disease Genetics Consortium (ADGC), Gerard D Schellenberg, Thomas J Montine
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004606 (2014)
Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight into molecular pathogenesis. We performed a genome-wide association study and analysis of kno
Externí odkaz:
https://doaj.org/article/16fab959c9274eda9e554f003340125a
Autor:
Charles H Greenberg, Matthew P Frosch, Joshua N Goldstein, Jonathan Rosand, Steven M Greenberg
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48458 (2012)
The mechanism for hemorrhage enlargement in the brain, a key determinant of patient outcome following hemorrhagic stroke, is unknown. We performed computer-based stochastic simulation of one proposed mechanism, in which hemorrhages grow in "domino" f
Externí odkaz:
https://doaj.org/article/de2d19e39a6c43398a181733593c3281
Autor:
Clara Muñoz-Castro, Ayush Noori, Colin G. Magdamo, Zhaozhi Li, Jordan D. Marks, Matthew P. Frosch, Sudeshna Das, Bradley T. Hyman, Alberto Serrano-Pozo
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-20 (2022)
Abstract Background Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s disease (AD) brain. Single-nuclei and single-cell RNA-seq have revealed multiple states or subpopulations of these
Externí odkaz:
https://doaj.org/article/0058df1039144d51a4e84f5e8c7c26e6
Autor:
Waijiao Cai, Pranay Srivastava, Danielle Feng, Yue Lin, Charles R. Vanderburg, Yuehang Xu, Pamela Mclean, Matthew P. Frosch, David E. Fisher, Michael A. Schwarzschild, Xiqun Chen
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-21 (2022)
Abstract Background Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson’s disease (PD). We previously showed that MC1R signaling can facilitate nigrostriatal dop
Externí odkaz:
https://doaj.org/article/f84f67257c0e4f8eb3eaba2a035b1cb8
Autor:
Eric M. Reiman, Joseph F. Arboleda-Velasquez, Yakeel T. Quiroz, Matthew J. Huentelman, Thomas G. Beach, Richard J. Caselli, Yinghua Chen, Yi Su, Amanda J. Myers, John Hardy, Jean Paul Vonsattel, Steven G. Younkin, David A. Bennett, Philip L. De Jager, Eric B. Larson, Paul K. Crane, C. Dirk Keene, M. Ilyas Kamboh, Julia K. Kofler, Linda Duque, John R. Gilbert, Harry E. Gwirtsman, Joseph D. Buxbaum, Dennis W. Dickson, Matthew P. Frosch, Bernardino F. Ghetti, Kathryn L. Lunetta, Li-San Wang, Bradley T. Hyman, Walter A. Kukull, Tatiana Foroud, Jonathan L. Haines, Richard P. Mayeux, Margaret A. Pericak-Vance, Julie A. Schneider, John Q. Trojanowski, Lindsay A. Farrer, Gerard D. Schellenberg, Gary W. Beecham, Thomas J. Montine, Gyungah R. Jun, The Alzheimer’s Disease Genetics Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE
Externí odkaz:
https://doaj.org/article/8db8cb1befa541b785dc4ef289037901
Autor:
Anne Piantadosi, Shibani S. Mukerji, Simon Ye, Michael J. Leone, Lisa M. Freimark, Daniel Park, Gordon Adams, Jacob Lemieux, Sanjat Kanjilal, Isaac H. Solomon, Asim A. Ahmed, Robert Goldstein, Vijay Ganesh, Bridget Ostrem, Kaelyn C. Cummins, Jesse M. Thon, Cormac M. Kinsella, Eric Rosenberg, Matthew P. Frosch, Marcia B. Goldberg, Tracey A. Cho, Pardis Sabeti
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Meningitis and encephalitis are leading causes of central nervous system (CNS) disease and often result in severe neurological compromise or death. Traditional diagnostic workflows largely rely on pathogen-specific tests, sometimes over days
Externí odkaz:
https://doaj.org/article/257d13788e6c45d0b65f5a35776fbd4c
Autor:
Christopher M. William, Matthew A. Stern, Xuewei Pei, Lubna Saqran, Margish Ramani, Matthew P. Frosch, Bradley T. Hyman
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105344- (2021)
Introduction: A variety of transgenic and knock-in mice that express mutant alleles of Amyloid precursor protein (APP) have been used to model the effects of amyloid-beta (Aβ) on circuit function in Alzheimer's disease (AD); however phenotypes descr
Externí odkaz:
https://doaj.org/article/34fd6cb2979d46dbae6bcb9f02bf22d6
Autor:
Isabel Barroeta-Espar, Laura D. Weinstock, Beatriz G. Perez-Nievas, Avery C. Meltzer, Michael Siao Tick Chong, Ana C. Amaral, Melissa E. Murray, Krista L. Moulder, John C. Morris, Nigel J. Cairns, Joseph E. Parisi, Val J. Lowe, Ronald C. Petersen, Julia Kofler, Milos D. Ikonomovic, Oscar López, William E. Klunk, Richard P. Mayeux, Matthew P. Frosch, Levi B. Wood, Teresa Gomez-Isla
Publikováno v:
Neurobiology of Disease, Vol 121, Iss , Pp 327-337 (2019)
Our group has previously studied the brains of some unique individuals who are able to tolerate robust amounts of Alzheimer's pathological lesions (amyloid plaques and neurofibrillary tangles) without experiencing dementia while alive. These rare res
Externí odkaz:
https://doaj.org/article/fb448af25f8c45e29b685fb3b437ea3f
Autor:
Stefan C. Halvorsen, Yair Benita, Megan Hopton, Brooke Hoppe, Hilmar O. Gunnlaugsson, Parimal Korgaonkar, Charles R. Vanderburg, G. Petur Nielsen, Nicole Trepanowski, Jaime H. Cheah, Matthew P. Frosch, Joseph H. Schwab, Andrew E. Rosenberg, Francis J. Hornicek, Slim Sassi
Publikováno v:
The American Journal of Pathology. 193:532-547
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a798175f7a645df010844afa6d465fbd
https://doi.org/10.1016/j.ajpath.2023.01.014
https://doi.org/10.1016/j.ajpath.2023.01.014