Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Matthew O. Barrett"'
Autor:
Lijun Song, Martijn D. P. Risseeuw, Izet Karalic, Matthew O. Barrett, Kyle A. Brown, T. Kendall Harden, Serge Van Calenbergh
Publikováno v:
Molecules, Vol 19, Iss 4, Pp 4313-4325 (2014)
In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands. A silyl-Hilbert-Johnson reaction of six quinazoline-2,4-(1H,3H)-dione-like base moieties wit
Externí odkaz:
https://doaj.org/article/90bc235eefcf4629b2b6b8d027b90751
Autor:
Jarod Waybright, John Sondek, Stuart Endo-Streeter, T. Kendall Harden, Qisheng Zhang, Nicole Hajicek, Xiaoyang Wang, Christian Wohlfeld, Weigang Huang, Matthew O. Barrett
Publikováno v:
The Journal of biological chemistry. 293(5)
A diverse group of cell-surface receptors, including many G protein-coupled receptors and receptor tyrosine kinases, activate phospholipase C (PLC) isozymes to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol
Autor:
Silvia Paoletta, Clarissa D. Weitzer, Vsevolod Katritch, Kenneth A. Jacobson, T. Kendall Harden, Evgeny Kiselev, Qiang Zhao, Kyle A. Brown, Andrew L. Yin, Raymond C. Stevens, Matthew O. Barrett, Eva Hammes
Publikováno v:
ACS Chemical Biology
The P2Y14 receptor (P2Y14R), one of eight P2Y G protein-coupled receptors (GPCR), is involved in inflammatory, endocrine, and hypoxic processes and is an attractive pharmaceutical target. The goal of this research is to develop high-affinity P2Y14R f
Autor:
John Sondek, Qisheng Zhang, Matthew O. Barrett, T. Kendall Harden, Stephanie N. Hicks, Weigang Huang, Nicole Hajicek
Publikováno v:
Journal of Biological Chemistry. 288:5840-5848
Phospholipase C (PLC) isozymes are important signaling molecules, but few small molecule modulators are available to pharmacologically regulate their function. With the goal of developing a general approach for identification of novel PLC inhibitors,
Publikováno v:
Biochemistry. 51:5300-5306
The capacity to monitor spatiotemporal activity of phospholipase C (PLC) isozymes with a PLC-selective sensor would dramatically enhance understanding of the physiological function and disease relevance of these signaling proteins. Previous structura
Autor:
Matthew O. Barrett, Arijit Das, Kenneth A. Jacobson, Hyojin Ko, T. Kendall Harden, Lauren E. Burianek
Publikováno v:
Journal of Medicinal Chemistry. 53:471-480
Uridine-5'-diphosphoglucose (UDPG) activates the P2Y(14) receptor, a neuroimmune system GPCR. P2Y(14) receptor tolerates glucose substitution with small alkyl or aryl groups or its truncation to uridine 5'-diphosphate (UDP), a full agonist at the hum
Publikováno v:
Seminars in Arthroplasty. 16:198-207
The complications and difficulty associated with the minimally invasive surgery (MIS) two-incision technique in total hip replacement have been well publicized. In this report, the authors describe a modified technique for primary total hip replaceme
Publikováno v:
Seminars in Arthroplasty. 16:239-247
A review of the current orthopedic literature reveals some evidence that a limited incision approach may be associated with a higher complication rate, particularly in the learning phase of the minimally invasive joint replacement surgery (MIS) techn
Autor:
Weigang Huang, Thomas H. Charpentier, Qisheng Zhang, G L Waldo, John Sondek, T. Kendall Harden, Matthew O. Barrett
Publikováno v:
The Journal of biological chemistry. 289(43)
All peripheral membrane proteins must negotiate unique constraints intrinsic to the biological interface of lipid bilayers and the cytosol. Phospholipase C-β (PLC-β) isozymes hydrolyze the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2)
Autor:
P. Suresh Jayasekara, Matthew O. Barrett, Eva Hammes, Kenneth A. Jacobson, Kyle A. Brown, Christopher B. Ball, Ramachandran Balasubramanian, T. Kendall Harden
Publikováno v:
Journal of Medicinal Chemistry
Extended N(4)-(3-arylpropyl)oxy derivatives of uridine-5'-triphosphate were synthesized and potently stimulated phospholipase C stimulation in astrocytoma cells expressing G protein-coupled human (h) P2Y receptors (P2YRs) activated by UTP (P2Y2/4R) o