Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Matthew N. Poy"'
Autor:
Katharina Nimptsch, Elif Ece Aydin, Rafael Francisco Rios Chavarria, Jürgen Janke, Matthew N. Poy, Claus Oxvig, Astrid Steinbrecher, Tobias Pischon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The pappalysins pregnancy associated plasma protein-A (PAPP-A) and -A2 (PAPP-A2) act as proteinases of insulin-like growth factor-1 (IGF-1) binding proteins, while stanniocalcin-2 (STC2) was identified as a pappalysin inhibitor. While there
Externí odkaz:
https://doaj.org/article/8bb7666141f54ffcaaf21618e77ebd91
Autor:
Yu-Te Yeh, Chandan Sona, Xin Yan, Yunxiao Li, Adrija Pathak, Mark I. McDermott, Zhigang Xie, Liangwen Liu, Anoop Arunagiri, Yuting Wang, Amaury Cazenave-Gassiot, Adhideb Ghosh, Ferdinand von Meyenn, Sivarajan Kumarasamy, Sonia M. Najjar, Shiqi Jia, Markus R. Wenk, Alexis Traynor-Kaplan, Peter Arvan, Sebastian Barg, Vytas A. Bankaitis, Matthew N. Poy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kina
Externí odkaz:
https://doaj.org/article/07e41593908f4d84a89d335f3da86332
Autor:
Chandan Sona, Yu-Te Yeh, Andreas Patsalos, Laszlo Halasz, Xin Yan, Natalia L. Kononenko, Laszlo Nagy, Matthew N. Poy
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
BACKGROUND Pathophysiology of type 1 diabetes (T1D) is illustrated by pancreatic islet infiltration of inflammatory lymphocytes, including CD8+ T cells; however, the molecular factors mediating their recruitment remain unknown. We hypothesized that s
Externí odkaz:
https://doaj.org/article/340a403c8bce4728982b8d90238639dd
Autor:
Xin Yan, Zhen Wang, Christopher A. Bishop, Karolin Weitkunat, Xiao Feng, Marcel Tarbier, Jiankai Luo, Marc R. Friedländer, Ralph Burkhardt, Susanne Klaus, Thomas E. Willnow, Matthew N. Poy
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 15-24 (2018)
Objective: The liver performs a central role in regulating energy homeostasis by increasing glucose output during fasting. Recent studies on Argonaute2 (Ago2), a key RNA-binding protein mediating the microRNA pathway, have illustrated its role in ada
Externí odkaz:
https://doaj.org/article/3a0c1c96f60c484fb637862e87d3c2aa
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 96-105 (2018)
Objective: Actin cytoskeleton remodeling is necessary for glucose-stimulated insulin secretion in pancreatic β-cells. A mechanistic understanding of actin dynamics in the islet is paramount to a better comprehension of β-cell dysfunction in diabete
Externí odkaz:
https://doaj.org/article/719eab4614cd42cf889190c03e5d132c
Autor:
Xin Yan, Zhen Wang, Vanessa Schmidt, Anton Gauert, Thomas E. Willnow, Matthias Heinig, Matthew N. Poy
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 180-188 (2018)
Objective: Obesity is strongly linked to genes regulating neuronal signaling and function, implicating the central nervous system in the maintenance of body weight and energy metabolism. Genome-wide association studies identified significant associat
Externí odkaz:
https://doaj.org/article/875dc3eeb26c499d8bd9cfd82eed5066
Autor:
Sara Nagosa, Friederike Leesch, Daria Putin, Swarnabh Bhattacharya, Anna Altshuler, Laura Serror, Aya Amitai-Lange, Waseem Nasser, Edith Aberdam, Matthieu Rouleau, Sudhir G. Tattikota, Matthew N. Poy, Daniel Aberdam, Ruby Shalom-Feuerstein
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1991-2004 (2017)
Summary: miR-184 is a highly evolutionary conserved microRNA (miRNA) from fly to human. The importance of miR-184 was underscored by the discovery that point mutations in miR-184 gene led to corneal/lens blinding disease. However, miR-184-related fun
Externí odkaz:
https://doaj.org/article/820af42a71f64d11a72a250c49004c75
Autor:
Yu-Te Yeh, Chandan Sona, Xin Yan, Adrija Pathak, Mark I. McDermott, Zhigang Xie, Liangwen Liu, Anoop Arunagiri, Yuting Wang, Amaury Cazenave-Gassiot, Adhideb Ghosh, Ferdinand von Meyenn, Sivarajan Kumarasamy, Sonia M. Najjar, Shiqi Jia, Markus R. Wenk, Alexis Traynor-Kaplan, Peter Arvan, Sebastian Barg, Vytas A. Bankaitis, Matthew N. Poy
SUMMARYDefects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7de2fdff4532dc577b77f8df4fd2e23
https://doi.org/10.1101/2022.07.06.498991
https://doi.org/10.1101/2022.07.06.498991
Autor:
Ralph Burkhardt, Xiao Feng, Marc R. Friedländer, Susanne Klaus, Karolin Weitkunat, Marcel Tarbier, Matthew N. Poy, Christopher A. Bishop, Xin Yan, Thomas E. Willnow, Zhen Wang, Jiankai Luo
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 18, Iss, Pp 15-24 (2018)
Molecular Metabolism, Vol 18, Iss, Pp 15-24 (2018)
Objective The liver performs a central role in regulating energy homeostasis by increasing glucose output during fasting. Recent studies on Argonaute2 (Ago2), a key RNA-binding protein mediating the microRNA pathway, have illustrated its role in adap
Autor:
Katrina J. Binger, Klemens Raile, Diana M. Willmes, Sabrina Geisberger, Michele Solimena, Matthew N. Poy, Martin Neukam, Sabrina Wurmsee, Ralf Dechend, Dmytro Puchkov, Andreas L. Birkenfeld, Dominik N. Müller, Genevieve Nguyen, Thomas Kurth, Sudhir Gopal Tattikota, Fatimunnisa Qadri
Publikováno v:
Proc. Natl. Acad. Sci. U.S.A. 116, 19983-19988 (2019)
Pancreatic β cells store insulin within secretory granules which undergo exocytosis upon elevation of blood glucose levels. Crinophagy and autophagy are instead responsible to deliver damaged or old granules to acidic lysosomes for intracellular deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644d6cf759ccae84eed07fcbe2e66df0
https://europepmc.org/articles/PMC6778207/
https://europepmc.org/articles/PMC6778207/