Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Matthew N. Mattson"'
Autor:
Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
Publikováno v:
Journal of Medicinal Chemistry. 56:5261-5274
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5b61686f688dd0abd9c5edac66d7201
https://doi.org/10.1021/jm301741t
https://doi.org/10.1021/jm301741t
Autor:
Chris M. Semko, Danielle L. Aubele, Guriqbal S. Basi, Wes Zmolek, Gary Probst, Matthew N. Mattson, Elizabeth F. Brigham, Erich Goldbach, Karina Wong, William A Wallace, John-Michael Sauer, Hing L. Sham, Lan K. Nguyen, Michael P. Bova, Andrei W. Konradi, Albert W. Garofalo, Susanna S. Hemphill, Darren B. Dressen, Kevin P. Quinn, Minghua Sun, Anh P. Truong, Simeon Bowers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5791-5794
The structure–activity relationship (SAR) of a novel, potent and metabolically stable series of sulfonamide-pyrazoles that attenuate β-amyloid peptide synthesis via γ-secretase inhibition is detailed herein. Sulfonamide-pyrazoles that are efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c797a2f9e3d425d83f37dc2fbd3a6ac
https://doi.org/10.1016/j.bmcl.2011.08.008
https://doi.org/10.1016/j.bmcl.2011.08.008
Publikováno v:
The Journal of Organic Chemistry. 67:5913-5918
The synthesis of a chiral pilocarpine analogue 3 in which the lactone ring is replaced by an oxazolidinone and the bridging methylene group is in the ketone oxidation state has been accomplished. The utility of this compound as a key intermediate for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a57a08e823d919833205013a54b12e
https://doi.org/10.1021/jo0111210
https://doi.org/10.1021/jo0111210
Autor:
Gary, Probst, Danielle L, Aubele, Simeon, Bowers, Darren, Dressen, Albert W, Garofalo, Roy K, Hom, Andrei W, Konradi, Jennifer L, Marugg, Matthew N, Mattson, Martin L, Neitzel, Chris M, Semko, Hing L, Sham, Jenifer, Smith, Minghua, Sun, Anh P, Truong, Xiaocong M, Ye, Ying-Zi, Xu, Michael S, Dappen, Jacek J, Jagodzinski, Pamela S, Keim, Brian, Peterson, Lee H, Latimer, David, Quincy, Jing, Wu, Erich, Goldbach, Daniel K, Ness, Kevin P, Quinn, John-Michael, Sauer, Karina, Wong, Hongbin, Zhang, Wes, Zmolek, Elizabeth F, Brigham, Dora, Kholodenko, Kang, Hu, Grace T, Kwong, Michael, Lee, Anna, Liao, Ruth N, Motter, Patricia, Sacayon, Pamela, Santiago, Christopher, Willits, Frédérique, Bard, Michael P, Bova, Susanna S, Hemphill, Lam, Nguyen, Lany, Ruslim, Kevin, Tanaka, Pearl, Tanaka, William, Wallace, Ted A, Yednock, Guriqbal S, Basi
Publikováno v:
Journal of medicinal chemistry. 56(13)
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::109e2b6e92821a752624dca210f7b056
https://pubmed.ncbi.nlm.nih.gov/23713656
https://pubmed.ncbi.nlm.nih.gov/23713656
Autor:
Matthew N. Mattson, Henry Rapoport
Publikováno v:
The Journal of Organic Chemistry. 61:6071-6074
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cfa146a57ba4bc07a64573b6911c3e2
https://doi.org/10.1021/jo9607471
https://doi.org/10.1021/jo9607471
Publikováno v:
Tetrahedron Letters. 36:7015-7018
A key mechanistic test is performed to determine whether cationic iron carbene complexes may function as initiators of cationic alkene cyclization reactions. Generation of a cationic iron carbene complex 15 within a framework containing a 1,5-diene s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3adda1abb6b1711499d7eb298e20509d
https://doi.org/10.1016/0040-4039(95)01452-n
https://doi.org/10.1016/0040-4039(95)01452-n
Autor:
Henry Rapoport, Matthew N. Mattson
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52a1e663c5e1a7b89f494c1a8372dbce
https://doi.org/10.1002/chin.199703141
https://doi.org/10.1002/chin.199703141
Autor:
Guriqbal S. Basi, Hongbin Zhang, Pamela S. Keim, Michael A. Pleiss, Martin L. Neitzel, Erich Goldbach, Semko Christopher M, David A. Quincy, Albert W. Garofalo, Andrei W. Konradi, John-Michael Sauer, Matthew N. Mattson, Hing L. Sham, Elizabeth F. Brigham
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(7)
Utilizing a pharmacophore hypothesis, previously described gamma-secretase inhibiting HTS hits were evolved into novel tricyclic sulfonamide-pyrazoles, with high in vitro potency, good brain penetration, low metabolic stability, and high clearance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0bbae13a02ac5307da21f3ab0837c81
https://pubmed.ncbi.nlm.nih.gov/20206516
https://pubmed.ncbi.nlm.nih.gov/20206516
Publikováno v:
Toxicology letters. 155(1)
Troglitazone, a thiazolidinedione containing compound, was widely used to treat non-insulin dependent-diabetes. Unfortunately, troglitazone was associated with a sporadic liver toxicity that led to a cessation of its use clinically. Here we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bf8ff24be967c0a5b51cbde81df304
https://pubmed.ncbi.nlm.nih.gov/15585358
https://pubmed.ncbi.nlm.nih.gov/15585358
Autor:
Michael P. Bova, Meire C.D. Bremer, Matthew N. Mattson, Gerald Mcmahon, Danny Tam, Jon M. Fukuto, Stefan Vasile, Audie Rice, Terence Hui, Leslie J. Holsinger
Publikováno v:
Archives of biochemistry and biophysics. 429(1)
Here, we report the identification and characterization of five ortho-quinone inhibitors of PTPalpha. We observed that the potency of these compounds in biochemical assays was markedly enhanced by the presence of DTT. A kinetic analysis suggested tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b0e19b82e17271f94d6c3cd9292892
https://pubmed.ncbi.nlm.nih.gov/15288807
https://pubmed.ncbi.nlm.nih.gov/15288807