Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Matthew N. Clemenzi"'
Autor:
Erika K. Tse, Alexandre Martchenko, Denise D. Belsham, Neruja Loganathan, Matthew N. Clemenzi, Patricia L. Brubaker
Publikováno v:
Molecular and cellular endocrinology. 507
Western diets that are high in saturated fat and sugar disrupt circadian rhythms, induce weight gain, and lead to metabolic diseases including obesity. However, the mechanistic link between altered circadian rhythms and energy homeostasis remains poo
Publikováno v:
Journal of the Endocrine Society
Circadian rhythms drive the timing of daily physiological functions, including food intake. These cellular rhythms depend on the intricate regulation of core clock genes, such as BMAL1. Disruptions of the molecular clock in rodents have been shown to
Publikováno v:
Journal of neuroendocrinology. 31(1)
The links between obesity, inflammation and insulin resistance, which are all key characteristics of type 2 diabetes mellitus, are yet to be delineated in the brain. One of the key neuroinflammatory proteins detected in the hypothalamus with over-nut
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 315(2)
The brain, specifically the hypothalamus, controls whole body energy and glucose homeostasis through neurons that synthesize specific neuropeptides, whereas hypothalamic dysfunction is linked directly to insulin resistance, obesity, and type 2 diabet