Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Matthew N Rasband"'
Autor:
Sharon R Stevens, Colleen M Longley, Yuki Ogawa, Lindsay H Teliska, Anithachristy S Arumanayagam, Supna Nair, Juan A Oses-Prieto, Alma L Burlingame, Matthew D Cykowski, Mingshan Xue, Matthew N Rasband
Publikováno v:
eLife, Vol 10 (2021)
Neuronal ankyrins cluster and link membrane proteins to the actin and spectrin-based cytoskeleton. Among the three vertebrate ankyrins, little is known about neuronal Ankyrin-R (AnkR). We report AnkR is highly enriched in Pv+ fast-spiking interneuron
Externí odkaz:
https://doaj.org/article/7e8cf05eff984c3bb435d5a3eff36db4
Autor:
Xin Zhou, Seula Shin, Chenxi He, Qiang Zhang, Matthew N Rasband, Jiangong Ren, Congxin Dai, Rocío I Zorrilla-Veloz, Takashi Shingu, Liang Yuan, Yunfei Wang, Yiwen Chen, Fei Lan, Jian Hu
Publikováno v:
eLife, Vol 10 (2021)
Myelination depends on timely, precise control of oligodendrocyte differentiation and myelinogenesis. Cholesterol is the most abundant component of myelin and essential for myelin membrane assembly in the central nervous system. However, the underlyi
Externí odkaz:
https://doaj.org/article/e845eaeb64b84ef2807b2cdb227342fc
Autor:
Cheng-Hsin Liu, Ryan Seo, Tammy Szu-Yu Ho, Michael Stankewich, Peter J Mohler, Thomas J Hund, Jeffrey L Noebels, Matthew N Rasband
Publikováno v:
eLife, Vol 9 (2020)
Previously, we showed that a hierarchy of spectrin cytoskeletal proteins maintains nodal Na+ channels (Liu et al., 2020). Here, using mice lacking β1, β4, or β1/β4 spectrins, we show this hierarchy does not function at axon initial segments (AIS)
Externí odkaz:
https://doaj.org/article/b0a80c607d4b4ee5b9e6ed64b25767e2
Autor:
Jennifer Orthmann-Murphy, Cody L Call, Gian C Molina-Castro, Yu Chen Hsieh, Matthew N Rasband, Peter A Calabresi, Dwight E Bergles
Publikováno v:
eLife, Vol 9 (2020)
Destruction of oligodendrocytes and myelin sheaths in cortical gray matter profoundly alters neural activity and is associated with cognitive disability in multiple sclerosis (MS). Myelin can be restored by regenerating oligodendrocytes from resident
Externí odkaz:
https://doaj.org/article/3e88511fa920405d95c9ba12f7130d67
Autor:
Cheng-Hsin Liu, Sharon R Stevens, Lindsay H Teliska, Michael Stankewich, Peter J Mohler, Thomas J Hund, Matthew N Rasband
Publikováno v:
eLife, Vol 9 (2020)
Clustered ion channels at nodes of Ranvier are critical for fast action potential propagation in myelinated axons. Axon-glia interactions converge on ankyrin and spectrin cytoskeletal proteins to cluster nodal Na+ channels during development. However
Externí odkaz:
https://doaj.org/article/8c24ae03c00e485d8d2d3fd446f61a16
Autor:
Veronique Amor, Chuansheng Zhang, Anna Vainshtein, Ao Zhang, Daniel R Zollinger, Yael Eshed-Eisenbach, Peter J Brophy, Matthew N Rasband, Elior Peles
Publikováno v:
eLife, Vol 6 (2017)
A high density of Na+ channels at nodes of Ranvier is necessary for rapid and efficient action potential propagation in myelinated axons. Na+ channel clustering is thought to depend on two axonal cell adhesion molecules that mediate interactions betw
Externí odkaz:
https://doaj.org/article/d413c2b8c31449edb49d2a41b7f1a9d2
Publikováno v:
eLife, Vol 5 (2016)
Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by mutations in Frataxin (FXN). Loss of FXN causes impaired mitochondrial function and iron homeostasis. An elevated production of reactive oxygen species (ROS) w
Externí odkaz:
https://doaj.org/article/b795688a74a048bcb40712b38d7070cf
Autor:
Kuchuan Chen, Guang Lin, Nele A Haelterman, Tammy Szu-Yu Ho, Tongchao Li, Zhihong Li, Lita Duraine, Brett H Graham, Manish Jaiswal, Shinya Yamamoto, Matthew N Rasband, Hugo J Bellen
Publikováno v:
eLife, Vol 5 (2016)
Mutations in Frataxin (FXN) cause Friedreich’s ataxia (FRDA), a recessive neurodegenerative disorder. Previous studies have proposed that loss of FXN causes mitochondrial dysfunction, which triggers elevated reactive oxygen species (ROS) and leads
Externí odkaz:
https://doaj.org/article/d43500dee4974bd596fee8b639e61034
Autor:
Miguel A Marin, Matthew N Rasband
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 8, Pp 1276-1277 (2017)
Externí odkaz:
https://doaj.org/article/4bf65f40d4f64c1fba011403ab44b634
Autor:
Daine R Lesniak, Kara L Marshall, Scott A Wellnitz, Blair A Jenkins, Yoshichika Baba, Matthew N Rasband, Gregory J Gerling, Ellen A Lumpkin
Publikováno v:
eLife, Vol 3 (2014)
Touch is encoded by cutaneous sensory neurons with diverse morphologies and physiological outputs. How neuronal architecture influences response properties is unknown. To elucidate the origin of firing patterns in branched mechanoreceptors, we combin
Externí odkaz:
https://doaj.org/article/1f0bedaa08314e70872e42b54421493e