Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Matthew Miyamoto"'
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Pediatric dilated cardiomyopathy (DCM) is a rare, yet life-threatening cardiovascular condition characterized by systolic dysfunction with biventricular dilatation and reduced myocardial contractility. Therapeutic options are limited with nearly 40%
Externí odkaz:
https://doaj.org/article/3e6e124da60a4ec29b2505a83ecf4da5
Autor:
Suraj Kannan, Matthew Miyamoto, Renjun Zhu, Michaela Lynott, Jason Guo, Elaine Zhelan Chen, Alexandre R. Colas, Brian Leei Lin, Chulan Kwon
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112330- (2023)
Summary: A limitation in the application of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) is the failure of these cells to achieve full functional maturity. The mechanisms by which directed differentiation differs from endogenous development
Externí odkaz:
https://doaj.org/article/d92eadf8c9ae407a8716be839d22c04c
Autor:
Sean A. Murphy, Matthew Miyamoto, Anaïs Kervadec, Suraj Kannan, Emmanouil Tampakakis, Sandeep Kambhampati, Brian Leei Lin, Sam Paek, Peter Andersen, Dong-Ik Lee, Renjun Zhu, Steven S. An, David A. Kass, Hideki Uosaki, Alexandre R. Colas, Chulan Kwon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cardiomyocyte maturation and the acquisition of phenotypes is poorly understood at the single cell level. Here, the authors analyse the transcriptome of single cells from neonatal to adult heart and reveal that peroxisome proliferator-activated recep
Externí odkaz:
https://doaj.org/article/e529861439104233888f042c1cc8bff3
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1009305 (2021)
The immaturity of pluripotent stem cell (PSC)-derived tissues has emerged as a universal problem for their biomedical applications. While efforts have been made to generate adult-like cells from PSCs, direct benchmarking of PSC-derived tissues agains
Externí odkaz:
https://doaj.org/article/837348608b634768ac6a20ed2cf424b7
Autor:
Peter Andersen, Emmanouil Tampakakis, Dennisse V. Jimenez, Suraj Kannan, Matthew Miyamoto, Hye Kyung Shin, Amir Saberi, Sean Murphy, Edrick Sulistio, Stephen P. Chelko, Chulan Kwon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The heart arises from distinct progenitor cells of both the first and second heart fields (FHF and SHF). Here, the authors generated precardiac organoids from mouse and human pluripotent cells and show that FHF and SHF cells form similarly to their i
Externí odkaz:
https://doaj.org/article/4409cf8489414ab6a468a5e03fc7c274
Autor:
Hideki Uosaki, Patrick Cahan, Dong I. Lee, Songnan Wang, Matthew Miyamoto, Laviel Fernandez, David A. Kass, Chulan Kwon
Publikováno v:
Cell Reports, Vol 13, Iss 8, Pp 1705-1716 (2015)
Decades of progress in developmental cardiology has advanced our understanding of the early aspects of heart development, including cardiomyocyte (CM) differentiation. However, control of the CM maturation that is subsequently required to generate ad
Externí odkaz:
https://doaj.org/article/a5ca7a44085f4f6fb83b23e8ba4ee555
Autor:
Young Wook Chun, Matthew Miyamoto, Charles H. Williams, Leif R. Neitzel, Maya Silver-Isenstadt, Adrian G. Cadar, Daniela T. Fuller, Daniel C. Fong, Hanhan Liu, Robert Lease, Sungseek Kim, Mikako Katagiri, Matthew D. Durbin, Kuo-Chen Wang, Tromondae K. Feaster, Calvin C. Sheng, M. Diana Neely, Urmila Sreenivasan, Marcia Cortes-Gutierrez, Aloke V. Finn, Rachel Schot, Grazia M.S. Mancini, Seth A. Ament, Kevin C. Ess, Aaron B. Bowman, Zhe Han, David P. Bichell, Yan Ru Su, Charles C. Hong
Publikováno v:
Circulation, 147(17), 1291-1303. Lippincott Williams & Wilkins
Background: During cardiomyocyte maturation, the centrosome, which functions as a microtubule organizing center in cardiomyocytes, undergoes dramatic structural reorganization where its components reorganize from being localized at the centriole to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3337e9bbe73dad57cf13a9b3b4beaf
https://doi.org/10.1161/circulationaha.122.060985
https://doi.org/10.1161/circulationaha.122.060985
Autor:
Matthew Miyamoto, Chulan Kwon
Publikováno v:
Cell Stem Cell. 29:1285-1287
In this issue of Cell Stem Cell, Yang et al. devise a protocol for induction and differentiation of human heart-field precursors, drawing on inspiration from in vivo development. Intricate computational analyses uncovered conserved factors governing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d91eb3ab22f9440407dc4995341bfbf
https://doi.org/10.1016/j.stem.2022.08.004
https://doi.org/10.1016/j.stem.2022.08.004
Autor:
Matthew Miyamoto, Suraj Kannan, Matthew J. Anderson, Xihe Liu, David Suh, Myo Htet, Biyi Li, Tejasvi Kakani, Sean Murphy, Emmanouil Tampakakis, Mark Lewandoski, Peter Andersen, Hideki Uosaki, Chulan Kwon
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The heart develops in a synchronized sequence of proliferation and differentiation of cardiac progenitor cells (CPCs) from two anatomically distinct pools of cells, the first heart field (FHF) and second heart field (SHF). Congenital heart defects ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a99cf6364e2e4493dd259a8a02d73fe6
https://doi.org/10.1073/pnas.2217687120
https://doi.org/10.1073/pnas.2217687120
Autor:
Suraj Kannan, Hideki Uosaki, Peter Andersen, William Miyamoto, Xihe Liu, Matthew Miyamoto, Sean Murphy, Emmanouil Tampakakis, Edrick Sulistio, Narutoshi Hibino, Lucy Nam, Chulan Kwon
Publikováno v:
Biochem Biophys Res Commun
The Notch pathway is an ancient intercellular signaling system with crucial roles in numerous cell-fate decision processes across species. While the canonical pathway is activated by ligand-induced cleavage and nuclear localization of membrane-bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b865ff40ae9c74911bb122da7376fffe
https://doi.org/10.1016/j.bbrc.2021.08.094
https://doi.org/10.1016/j.bbrc.2021.08.094