Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Matthew Mitschelen"'
Autor:
Heather D. VanGuilder, Julie A. Farley, Han Yan, Colleen A. Van Kirk, Matthew Mitschelen, William E. Sonntag, Willard M. Freeman
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 1, Pp 201-212 (2011)
Age-related cognitive decline occurs without frank neurodegeneration and is the most common cause of memory impairment in aging individuals. With increasing longevity, cognitive deficits, especially in hippocampus-dependent memory processes, are incr
Externí odkaz:
https://doaj.org/article/1167c0ebb88a4dd7b5bb1f5723e095d0
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30444 (2012)
Whole brain radiation therapy (WBRT) is commonly used for treatment of primary and metastatic brain tumors; however, cognitive impairment occurs in 40-50% of brain tumor survivors. The etiology of the cognitive impairment following WBRT remains elusi
Externí odkaz:
https://doaj.org/article/2d6d67fa04944b86984bad1a5b7d5757
Autor:
Matthew Mitschelen, William E. Sonntag, Yuji Ikeno, Julie A. Farley, Han Yan, Jacquelyn C Herron, Erik L. Hodges, Nicole M. Ashpole, Anna Csiszar, Mary Beth Humphrey, Sreemathi Logan, Zoltan Ungvari
Publikováno v:
Journal of Bone and Mineral Research. 31:443-454
Advanced aging is associated with increased risk of bone fracture, especially within the vertebrae, which exhibit significant reductions in trabecular bone structure. Aging is also associated with a reduction in circulating levels of insulin-like gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b761adfd68ac6bcbda80cb9283b23cf8
https://doi.org/10.1002/jbmr.2689
https://doi.org/10.1002/jbmr.2689
Autor:
Zoltan Ungvari, Andriy Yabluchanskiy, Julie A. Farley, Anna Csiszar, Han Yan, Matthew Mitschelen, Gene B. Hubbard, Constantin Georgescu, Sixia Chen, Erik L. Hodges, Nicole M. Ashpole, Yuji Ikeno, Sreemathi Logan, William E. Sonntag
Publikováno v:
GeroScience. 39(2)
Reduced circulating levels of IGF-1 have been proposed as a conserved anti-aging mechanism that contributes to increased lifespan in diverse experimental models. However, IGF-1 has also been shown to be essential for normal development and the mainte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beeb3be8a69496d575fcab98f04b8877
https://pubmed.ncbi.nlm.nih.gov/28409331
https://pubmed.ncbi.nlm.nih.gov/28409331
Autor:
Junie P. Warrington, Danuta Sosnowska, Julie A. Farley, William E. Sonntag, Han Yan, Matthew Mitschelen, Nicole M. Ashpole, Anna Csiszar, Tripti Gautam, Zoltan Ungvari
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 307:H858-H868
Whole brain radiation therapy (WBRT) induces profound cerebral microvascular rarefaction throughout the hippocampus. Despite the vascular loss and localized cerebral hypoxia, angiogenesis fails to occur, which subsequently induces long-term deficits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726cfb75228d3c128459e2c2a3d77951
https://doi.org/10.1152/ajpheart.00308.2014
https://doi.org/10.1152/ajpheart.00308.2014
Autor:
Junie P. Warrington, Song Han, Erik L. Hodges, Nicole M. Ashpole, Matthew Mitschelen, Zoltan Ungvari, Peter Toth, Kar Ming Fung, Han Yan, Anna Csiszar, William E. Sonntag, Julie A. Farley
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 69:1353-1362
Aging is a major risk factor for cerebrovascular disease. Growth hormone (GH) and its anabolic mediator, insulin-like growth factor (IGF)-1, decrease with advancing age and this decline has been shown to promote vascular dysfunction. In addition, low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e832695d4646c097c66aff18875cda
https://doi.org/10.1093/gerona/glu118
https://doi.org/10.1093/gerona/glu118
Autor:
Zoltan Ungvari, Zsuzsanna Tucsek, Anna Csiszar, Matthew Mitschelen, Gabor Szalai, Danuta Sosnowska, Peter Toth, Tripti Gautam, William E. Sonntag, Akos Koller
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 69:1212-1226
There is growing evidence that obesity has deleterious effects on the brain and cognitive function in the elderly population. However, the specific mechanisms through which aging and obesity interact to promote cognitive decline remain unclear. To te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3a7b429c848d6d3fc9fdbfc258edf0
https://doi.org/10.1093/gerona/glt177
https://doi.org/10.1093/gerona/glt177
Autor:
Junie P. Warrington, Vijay P. Kale, Jacob M. Serfass, Colleen A. Van Kirk, Willard M. Freeman, Matthew Mitschelen, Julie A. Farley, Heather D. VanGuilder Starkey, Song Han, Georgina V. Bixler, William E. Sonntag, Caesar G. Imperio, Han Yan
Publikováno v:
Journal of Molecular Neuroscience. 48:111-126
The hippocampus undergoes changes with aging that impact neuronal function, such as synapse loss and altered neurotransmitter release. Nearly half of the aged population also develops deficits in spatial learning and memory. To identify age-related h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143676fa92f54286d3279f6a72da5511
https://doi.org/10.1007/s12031-012-9783-8
https://doi.org/10.1007/s12031-012-9783-8
Autor:
Anna Csiszar, Zoltan Ungvari, M. Noa Valcarcel-Ares, Danuta Sosnowska, Lora C. Bailey-Downs, William E. Sonntag, John T. Pinto, Jim Henthorn, Julie A. Farley, Peter Toth, Caroline E. Bass, Akos Koller, Praveen Ballabh, Matthew Mitschelen
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. :313-329
Recent studies demonstrate that age-related dysfunction of NF-E2-related factor-2 (Nrf2)-driven pathways impairs cellular redox homeostasis, exacerbating age-related cellular oxidative stress and increasing sensitivity of aged vessels to oxidative st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6e38275383c2b6973db3db17c29630
https://doi.org/10.1093/gerona/glr164
https://doi.org/10.1093/gerona/glr164
Autor:
Colleen A. Van Kirk, Han Yan, Matthew Mitschelen, Heather D. VanGuilder, Willard M. Freeman, William E. Sonntag, Julie A. Farley
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 1, Pp 201-212 (2011)
Age-related cognitive decline occurs without frank neurodegeneration and is the most common cause of memory impairment in aging individuals. With increasing longevity, cognitive deficits, especially in hippocampus-dependent memory processes, are incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd822a26fc3cb1c33f931a72213d93fb
https://doi.org/10.1016/j.nbd.2011.03.012
https://doi.org/10.1016/j.nbd.2011.03.012