Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Matthew Michael Hamilton"'
Autor:
Rebecca Taub, Robert Alan Goodnow, Lida Qi, Joseph Anthony Bilotta, Sherrie Lynn Pietranico-Cole, Yonglin Ren, Cheryl Spence, Jefferson Wright Tilley, Baolian Liu, Sung-Sau So, Kevin Richard Guertin, Karin Conde-Knape, Matthew Michael Hamilton, Nancy-Ellen Haynes, Kshitij Chhabilbhai Thakkar, Catherine Zwingelstein, Nathan Robert Scott, Paul Gillespie, Michael Paul Myers, Nader Fotouhi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2707-2711
Starting from screening hit, (4S,7R)-1,7,8,8-tetramethyl-2-phenyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (7), we optimized the potency and pharmacokinetic properties. This led to the identification of compounds with good in vivo activity in
Autor:
Yonglin Ren, Ryan Craig Schoenfeld, Adrian J. Fretland, Maria E. Fuentes, Kung-Ching Chang, Yimin Qian, Rachid Hamid, Yun Chen, Achyutharao Sidduri, Matthew Michael Hamilton, Christopher S. Stevenson, Gabriel Stephen Deems, Lin Zhang, Terry Truitt, Dramane Ibrahim Laine, Arjun Narayanan, Ruoqi Peng, David C. Budd, Matthew C. Lucas, Rama K. Kondru, Ruben Alvarez Sanchez
Publikováno v:
Journal of Medicinal Chemistry. 55:7920-7939
Lysophosphatidic acid is a class of bioactive phospholipid that mediates most of its biological effects through LPA receptors, of which six isoforms have been identified. The recent results from LPA1 knockout mice suggested that blocking LPA1 signali
Autor:
Stanley Wertheimer, Lee Apostle Mcdermott, Stuart Hayden, Weiya Yun, Yingsi Chen, Anjula Pamidimukkala, Rebecca Taub, Kuo-Sen Huang, Toni Whittard, Liang Guo, Shiming Li, Jenny Tan, Fariborz Firooznia, Adrian Wai-Hing Cheung, David Robert Bolin, Nicholas Marcopulos, Yimin Qian, Karin Conde-Knape, Mushtaq Ahmad, Gwendolyn Ramsey, Cristina M. Rondinone, Jefferson Wright Tilley, Matthew Michael Hamilton
Publikováno v:
Journal of Medicinal Chemistry. 54:2433-2446
Diacylglycerol acyltransferase-1 (DGAT-1) is the enzyme that catalyzes the final and committed step of triglyceride formation, namely, the acylation of diacylglycerol with acyl coenzyme A. DGAT-1 deficient mice demonstrate resistance to weight gain o