Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Matthew Martinson"'
Autor:
Jill Hallin, Vickie Bowcut, Andrew Calinisan, David M. Briere, Lauren Hargis, Lars D. Engstrom, Jade Laguer, James Medwid, Darin Vanderpool, Ella Lifset, David Trinh, Natalie Hoffman, Xiaolun Wang, J. David Lawson, Robin J. Gunn, Christopher R. Smith, Nicole C. Thomas, Matthew Martinson, Alex Bergstrom, Francis Sullivan, Karyn Bouhana, Shannon Winski, Leo He, Julio Fernandez-Banet, Adam Pavlicek, Jacob R. Haling, Lisa Rahbaek, Matthew A. Marx, Peter Olson, James G. Christensen
Publikováno v:
Nature Medicine. 28:2171-2182
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d677a7e099fb8459d3aaad7bbf29b468
https://doi.org/10.1038/s41591-022-02007-7
https://doi.org/10.1038/s41591-022-02007-7
Autor:
James Christensen, Jill Hallin, Vickie Bowcut, Andrew Calinisan, David Briere, Lauren Hargis, Lars Engstrom, Jade Laguer, James Medwid, Darin Vanderpool, Ella Lifset, David Trinh, Natalie Hoffman, Xiaolun Wang, J. Lawson, Robin Gunn, Christopher Smith, Nicole Thomas, Matthew Martinson, Alex Bergstrom, Francis Sullivan, Karyn Bouhana, Shannon Winski, Leo He, Fernandez-Banet Julio, Adam Pavlicek, Jacob Haling, Lisa Rahbaek, Matthew Marx, Peter Olson
The ability to effectively target mutated KRAS has remained elusive despite decades of research. The recent identification of KRASG12C inhibitors has provided an effective treatment option for patients harboring this particular mutation and has also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10fbcfa8cb41321f46bb73555a3d1e2c
https://doi.org/10.21203/rs.3.rs-1261963/v1
https://doi.org/10.21203/rs.3.rs-1261963/v1
Autor:
Jill, Hallin, Vickie, Bowcut, Andrew, Calinisan, David M, Briere, Lauren, Hargis, Lars D, Engstrom, Jade, Laguer, James, Medwid, Darin, Vanderpool, Ella, Lifset, David, Trinh, Natalie, Hoffman, Xiaolun, Wang, J, David Lawson, Robin J, Gunn, Christopher R, Smith, Nicole C, Thomas, Matthew, Martinson, Alex, Bergstrom, Francis, Sullivan, Karyn, Bouhana, Shannon, Winski, Leo, He, Julio, Fernandez-Banet, Adam, Pavlicek, Jacob R, Haling, Lisa, Rahbaek, Matthew A, Marx, Peter, Olson, James G, Christensen
Publikováno v:
Nature medicine. 28(10)
Recent progress in targeting KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a7ce4f063fa84ad1780e11dbfbdabc8
https://pubmed.ncbi.nlm.nih.gov/36216931
https://pubmed.ncbi.nlm.nih.gov/36216931
Autor:
Michael Burkard, Andrew T. Metcalf, Kristina West, Stephen E. Gould, Matthew Martinson, John Moffat, Kevin Rasor, Weiru Wang, Li Ren, Jacob Schwarz, Sheerin K. Shahidi-Latham, Patricia Pacheco, Huifen Chen, Jianping Yin, Jonas Grina, David A. Moreno, Rustam Ferdinand Garrey, James F. Blake, John Gaudino, Brian Dean
Publikováno v:
Journal of Medicinal Chemistry. 58:1976-1991
Using structure-based design, a novel series of pyridone ERK1/2 inhibitors was developed. Optimization led to the identification of (S)-14k, a potent, selective, and orally bioavailable agent that inhibited tumor growth in mouse xenograft models. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3388c0dfdd14bdd11fd71ab111383ba
https://doi.org/10.1021/jm501921k
https://doi.org/10.1021/jm501921k
Autor:
John Moffat, Marcia Belvin, Lichuan Liu, Jocelyn Chan, Li Ren, Kirk Robarge, Francis J. Sullivan, Jeffrey Stults, Jonas Grina, David A. Moreno, Ann Qin, Matthew Martinson, Stephen E. Gould, Jacob Schwarz, Kang-Jye Chou, Sheerin K. Shahidi-Latham, Lars Mueller, John Gaudino, Aihe Zhou, James F. Blake, Weiru Wang, Danette Dudley, Christine Orr, Michael Burkard, Thomas Hunsaker, Dolores Diaz, Mark Merchant, Huifen Chen, Jianping Yin, Patricia Pacheco, Kevin Rasor
Publikováno v:
Journal of medicinal chemistry. 59(12)
The extracellular signal-regulated kinases ERK1/2 represent an essential node within the RAS/RAF/MEK/ERK signaling cascade that is commonly activated by oncogenic mutations in BRAF or RAS or by upstream oncogenic signaling. While targeting upstream n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d609114730026c9434727995874843
https://pubmed.ncbi.nlm.nih.gov/27227380
https://pubmed.ncbi.nlm.nih.gov/27227380
Autor:
Josef R. Bencsik, Barbara J. Brandhuber, Banka Anna L, Guy Vigers, Nicholas J. Skelton, Stefan D. Gross, Wen-I Wu, Matthew Martinson, Ian S. Mitchell, Susan L. Gloor, Rui Xu, Keith Lee Spencer, Tyler Risom, James F. Blake, Nicholas C. Kallan, Eli M. Wallace, Tony Morales
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2335-2340
We describe the design and synthesis of novel bicyclic spiro sulfonamides as potent Akt inhibitors. Through structure-based rational design, we have successfully improved PKA selectivity of previously disclosed spirochromanes. Representative compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d464e766cfa3fd14ff059ee54510b6e
https://doi.org/10.1016/j.bmcl.2011.02.098
https://doi.org/10.1016/j.bmcl.2011.02.098
Autor:
Nicholas J. Skelton, Matthew Martinson, Ian S. Mitchell, Josef R. Bencsik, Susan L. Gloor, Tony Morales, Rui Xu, Keith Lee Spencer, Tyler Risom, Barbara J. Brandhuber, Guy Vigers, Nicholas C. Kallan, Justin W. Heizer, James F. Blake, Wen-I Wu, Stefan D. Gross
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2410-2414
A novel series of spirochromane pan-Akt inhibitors is reported. SAR optimization furnished compounds with improved enzyme potencies and excellent selectivity over the related AGC kinase PKA. Attempted replacement of the phenol hinge binder provided c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a61cc2ceaf948857e1551953322040
https://doi.org/10.1016/j.bmcl.2011.02.073
https://doi.org/10.1016/j.bmcl.2011.02.073
Autor:
Bryson Rast, Alexandre J. Buckmelter, Li Ren, Walter C. Voegtli, Greg Miknis, Robert J. Ely, Tony Morales, Guy Vigers, Nikole Randolph, Ellen R. Laird, Michele Callejo, Joseph P. Lyssikatos, Sarah Galbraith, Matthew Martinson, Stephen T. Schlachter, Barbara J. Brandhuber, Steve Wenglowsky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1243-1247
The development of inhibitors of B-Raf(V600E) serine-threonine kinase is described. Various head-groups were examined to optimize inhibitor activity and ADME properties. Several of the head-groups explored, including naphthol, phenol and hydroxyamidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73adb84e1114bda90d7b78517b2d0ef5
https://doi.org/10.1016/j.bmcl.2010.12.061
https://doi.org/10.1016/j.bmcl.2010.12.061
Autor:
Keith Lee Spencer, Tyler Risom, Guy Vigers, Nicholas J. Skelton, Stefan D. Gross, Nicholas C. Kallan, Josef R. Bencsik, James F. Blake, Matthew Martinson, Ian S. Mitchell, Rui Xu, Richard Woessner, Tony Morales, Susan L. Gloor, Dengming Xiao, Barbara J. Brandhuber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5607-5612
The discovery and optimization of a series of pyrrolopyrimidine based protein kinase B (Pkb/Akt) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent inhibition of all three Akt isoforms and knoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77658a908ccac79354e5f6c50c34c693
https://doi.org/10.1016/j.bmcl.2010.08.053
https://doi.org/10.1016/j.bmcl.2010.08.053
Autor:
Barbara J. Brandhuber, George T. Topalov, Michele Callejo, Matthew Martinson, Nikole Randolph, Susan L. Gloor, Ellen R. Laird, Brad Newhouse, Mike Welch, Joseph P. Lyssikatos, Joshua D. Hansen, Jonas Grina, Rich Woessner, Alan G. Olivero, Guy Vigers, Nicole M Littman, Tony Morales
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4692-4695
Herein we describe a novel pyrazole-based class of ATP competitive B-Raf inhibitors. These inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. A subset of these inhibitors has demonstrated the ability to inhibit downstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01679be6189825d6dd1ca0c8f7d6aab9
https://doi.org/10.1016/j.bmcl.2008.07.002
https://doi.org/10.1016/j.bmcl.2008.07.002