Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Matthew Mangan"'
Autor:
Marco Orecchioni, Kouji Kobiyama, Holger Winkels, Yanal Ghosheh, Sara McArdle, Zbigniew Mikulski, William B. Kiosses, Zhichao Fan, Lai Wen, Yunmin Jung, Payel Roy, Amal J. Ali, Yukiko Miyamoto, Matthew Mangan, Jeffrey Makings, Zhihao Wang, Angela Denn, Jenifer Vallejo, Michaela Owens, Christopher P. Durant, Simon Braumann, Navid Mader, Lin Li, Hiroaki Matsunami, Lars Eckmann, Eicke Latz, Zeneng Wang, Stanley L. Hazen, Klaus Ley
Publikováno v:
Science (New York, N.Y.), vol 375, iss 6577
Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors that have a central role in detecting odorants and the sense of smell. We
Autor:
Eicke Latz, Tomasz Próchnicki, Matilde B. Vasconcelos, Matthew Mangan, Kim Robinson, Sarah Rösing, Fraser Duthie, Lena Standke, Romina Kaiser, Maximilian Rothe, Dagmar Wachten, Claudia Günther, Thomas Kufer, Franklin Zhong
Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form inflammasome complexes with the adaptor ASC and caspase-1, inducing activation of IL-1β and IL-18, and gasdermin D-dependent cell death. The triggers and activation mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f357e61c38d001eef9288f9c4cd87d63
https://doi.org/10.21203/rs.3.rs-1295136/v1
https://doi.org/10.21203/rs.3.rs-1295136/v1
Autor:
Carmen Klepka, Moritz Sandmann, Helma Tatge, Matthew Mangan, Annabel Arens, Daniel Henkel, Ralf Gerhard
Publikováno v:
Molecular microbiology 117(2), 493-507 (2022). doi:10.1111/mmi.14864
TcdB is a potent cytotoxin produced by pathogenic Clostridioides difficile that inhibits Rho GTPases by mono-glucosylation. TcdB enters cells via receptor-mediated endocytosis. The pathogenic glucosyltransferase domain (GTD) egresses endosomes by pH-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af5bef71e9418fd4c0a2a3c1227bf30
https://pub.dzne.de/record/163585
https://pub.dzne.de/record/163585
Autor:
Ralf Gerhard, Matthew Mangan, Karsten Hiller, Veit Hornung, Eicke Latz, Dieter Jahn, Karoline Krause, Alexander Heinz, Friederike Gorki, Thomas S. Ebert, Florian I. Schmidt, Marcus Mauer
Pyrin is a cytosolic immune sensor that forms an inflammasome when bacterial virulence factors inhibit RhoA, triggering the release of inflammatory cytokines, including IL-1β. Gain of function mutations in the MEFV gene encoding Pyrin cause auto-inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc8e4717d3dff77f47c197703a2eef61
https://doi.org/10.1101/2021.07.07.451422
https://doi.org/10.1101/2021.07.07.451422
Autor:
Eicke Latz, Victor Saavedra, Matthew Mangan, Anke Penno, Mario A. Lauterbach, Lars Kuerschner, Christoph Thiele
Publikováno v:
Autophagy
Autophagy 17(8), 1947-1961 (2021). doi:10.1080/15548627.2020.1804677
Autophagy 17(8), 1947-1961 (2021). doi:10.1080/15548627.2020.1804677
1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids of clinical relevance as they are elevated in plasma of patients suffering from hereditary sensory and autonomic neuropathy (HSAN1) or type 2 diabetes. Their neurotoxicity is described best b
Autor:
Sabine Dickhöfer, Oliver Hantschel, Hubert Kalbacher, Anita Delor, Franziska Herster, Jasmin Kümmerle-Deschner, Bodo Grimbacher, Carsten L. Greve, Xiao Liu, Ana Marcu, Samuel Wagner, Hao Wu, Liudmila Andreeva, Ana Tapia-Abellán, Yamel Cardona Gloria, Alexander N.R. Weber, Marta Lovotti, Eicke Latz, Michael Scharl, Markus W. Löffler, Maria Mateo Tortola, Olaf-Oliver Wolz, Nadine A. Schilling, Peter Düwell, Matthew Mangan, Sangeetha Shankar, Tzu-Hsuan Chang, Zsofia Bittner, Stefan Stevanovic, Karlotta Bosch, Francesca Bork, Marianne R. Spalinger
Publikováno v:
Journal of experimental medicine 218(11), e20201656 (2021). doi:10.1084/jem.20201656
Activity of the NLRP3 inflammasome, a critical mediator of inflammation, is controlled by accessory proteins, posttranslational modifications, cellular localization, and oligomerization. How these factors relate is unclear. We show that a well-establ
Autor:
André Mateus, Mikhail M. Savitski, Haruna Imamura, Bogdan I. Florea, Wolf-Dietrich Hardt, Anna Sueki, Matthew Mangan, Boris Turk, Jeroen Krijgsveld, Eicke Latz, Nataša Kopitar-Jerala, Annika Hausmann, Jacob Bobonis, Gianluca Sigismondo, Matylda Zietek, Joel Selkrig, Athanasios Typas, Bachir El Debs, Pedro Beltrao, Nan Li, Herman S. Overkleeft
Publikováno v:
Nature Microbiology, 5, 1119-1133
Nature microbiology 5(9), 1119-1133 (2020). doi:10.1038/s41564-020-0736-7
Nature microbiology
Nature microbiology 5(9), 1119-1133 (2020). doi:10.1038/s41564-020-0736-7
Nature microbiology
The interplay between host and pathogen relies heavily on rapid protein synthesis and accurate protein targeting to ensure pathogen destruction. To gain insight into this dynamic interface, we combined Click chemistry with pulsed stable isotope label
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db73188e84a91adac41ce4e251895aa
http://hdl.handle.net/1887/3200848
http://hdl.handle.net/1887/3200848
Autor:
Jasmin Kümmerle-Deschner, Peter Düwell, Matthew Mangan, Ana Marcu, Olaf-Oliver Wolz, Ana Tapia-Abellán, Franziska Herster, Sangeetha Shankar, Hao Wu, Sabine Dickhöfer, Marta Lovotti, Anita Delor, Samuel Wagner, Liudmila Andreeva, Eicke Latz, Hubert Kalbacher, Markus W. Löffler, Bodo Grimbacher, Zsofia Bittner, Alexander N.R. Weber, Xiao Liu, Karlotta Bosch, Nadine A. Schilling, Stefan Stevanovic
Activity of the NLRP3 inflammasome, a critical mediator of inflammation (1), is controlled by accessory proteins (2, 3), post-translational modifications (4, 5), cellular localization (6, 7) and oligomerization (8). How these factors relate, is uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750f84b4b4fe9a704faa78e0a1d51e60
https://doi.org/10.1101/864702
https://doi.org/10.1101/864702
Autor:
Matthias Regner, Katrina Louise Scarff, Monica Devi Prakash, Carolina R. Melo-Silva, Aulikki Koskinen, Arno Müllbacher, Alexandra Rizzitelli, Jennii Luu, Matthew Mangan, Catherina H. Bird, Phillip I. Bird
Publikováno v:
Immunology & Cell Biology. 95:884-894
Intracellular serpins are proposed to inactivate proteases released from lysosome-related organelles into the host cell interior, preventing cell death. Serpinb9 opposes the immune cytotoxic protease, granzyme B, and in a number of settings protects
Autor:
Jose A Villadangos, Wolfgang Weninger, Alexandra Rizzitelli, L.T. Joeckel, Javier Vega-Ramos, Matthew Mangan, Dion Kaiserman, Phillip I. Bird, Andrew J. Mitchell, Ben Roediger
Publikováno v:
Molecular Immunology. 82:50-56
Serpinb9 (Sb9, also called Spi6) is an intracellular inhibitor of granzyme B (grB) that protects cytotoxic lymphocytes from grB-mediated death. In addition, Sb9 is also expressed in accessory immune cells, including dendritic cells (DCs), although it