Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Matthew M. Morrissette"'
Autor:
Rebecca B. White, Bradley K. Wong, Elizabeth A. Lyle, K.J. Stauffer, Matthew M. Morrissette, S. Dale Lewis, Joseph P. Vacca, Yvonne M. Leonard, Cynthia Miller-Stein, Audrey A. Wallace, Bobby J. Lucas, Daniel R. McMasters, Julie A. Krueger, Joseph J. Lynch, Terry A. Lyle, Denise C. Welsh, Peter D. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4161-4164
Modification of lead compound 1 by reducing lipophilicity in the P3 group produced a series of low molecular weight thrombin inhibitors with excellent potency in functional assays, metabolic stability, and oral bioavailability. These modifications le
Publikováno v:
Tetrahedron Letters. 40:7925-7928
This communication reveals the novel solution phase synthesis of an array of biologically relevant imidazolines in a remarkable ‘three-step-one-pot’ procedure, utilizing a Ugi/de-Boc/cyclization (UDC) strategy. Transformations are carried out in
Autor:
Matthew M. Morrissette, Kent Neuenschwander, Anthony C. Scotese, Salvino Joseph M, Rose Mathew, Shelley Darnbrough, Stephen M. Condon, Groneberg Robert D, Gerard McGeehan, Stevan W. Djuric, John W. Ullrich, Richard Labaudiniere, Robert L. Morris, Christopher J. Burns
Publikováno v:
Angewandte Chemie. 110:3044-3047
Uber nureinen Syntheseweg lassen sich Bibliotheken aus niedermolekularen Verbindungen aufbauen, die auf zwei Targetfamilien mit unterschiedlichen Funktionalitaten ausgerichtet sind. Dies wurde anhand der Entdeckung des Strukturtemplats 1 deutlich, da
Autor:
Wan-Kit Chan, Robert A. Galemmo, Charles A. Sutherland, Matthew M. Morrissette, Fu-Chih Huang, Poli Gregory B, Kevin J. Moriarty, William P. Dankulich, James D. Warus
Publikováno v:
Journal of Medicinal Chemistry. 39:3748-3755
This report describes the synthesis of a new class of LTB4 receptor antagonists containing [2-[methyl(2-phenethyl)amino]-2-oxoethyl]benzene as a key binding domain for interaction with high-affinity LTB4 receptors. In addition to this binding domain,
Autor:
Charles A. Sutherland, Matthew M. Morrissette, Robert A. Galemmo, Poli Gregory B, Wan K. Chan, Fu Chih Huang, William D. Dankulich, Kevin J. Moriarty, James D. Warus
Publikováno v:
Journal of Medicinal Chemistry. 39:3756-3768
N-Methyl-N-phenethylphenylacetamide has been reported to be a key binding domain to LTB4 receptors. Here we describe the synthesis and structure-activity relationship (SAR) studies of two new series of LTB4 receptor antagonists in which the phenyl ri
Autor:
Wan K. Chan, Kevin J. Moriarty, Fu Chih Huang, William D. Dankulich, Robert A. Galemmo, Charles A. Sutherland, Poli Gregory B, Matthew M. Morrissette, James D. Warus
Publikováno v:
ChemInform. 28
N-Methyl-N-phenethylphenylacetamide has been reported to be a key binding domain to LTB4 receptors. Here we describe the synthesis and structure-activity relationship (SAR) studies of two new series of LTB4 receptor antagonists in which the phenyl ri
Publikováno v:
ChemInform. 29
This communication describes the generation of high-yielding solution phase diketopiperazine libraries via a ‘3-step, 1-pot’ procedure, employing the Ugi multi-component reaction (MCR), followed by BOC deprotection and cyclization to diketopipera
Autor:
Christopher J. Burns, Shelley Darnbrough, Salvino Joseph M, Groneberg Robert D, Stevan W. Djuric, Matthew M. Morrissette, Robert L. Morris, Kent Neuenschwander, Richard Labaudiniere, Rose Mathew, Anthony C. Scotese, Stephen M. Condon, Gerard McGeehan, John W. Ullrich
Publikováno v:
Angewandte Chemie International Edition. 37:2848-2850
One common synthetic route creates small-molecule libraries directed toward two functionally distinct target families. The novel structural template 1 can independently display the necessary pharmacophore patterns for inhibition of members of two dif
Autor:
Matthew M. Morrissette, et al. et al.
Publikováno v:
ChemInform. 35
Autor:
Harold G. Selnick, Lawrence C. Kuo, Kellie J. Cutrona, Bobby J. Lucas, Kristen L. Glass, Joseph P. Vacca, Youwei Yan, S. Dale Lewis, Christina L. Newton, Daniel R. McMasters, Philippe G. Nantermet, Kenneth E. Rittle, William M. Sanders, Julie A. Krueger, Matthew M. Morrissette, James C. Barrow
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(20)
Thrombin inhibitors incorporating o -aminoalkylbenzylamides in the P1 position were designed, synthesized and found to have enhanced potency and selectivity in several different structural classes. X-ray crystallographic analysis of compound 24 bound