Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Matthew M. Hamilton"'
Autor:
Norma Rogers, Stephan Krapp, Faika Mseeh, Richard T. Lewis, Keith Mikule, Michelle Han, Jay Theroff, Yongying Jiang, Keith M. Wilcoxen, Cross Jason, Dana Pfaffinger, Michael J. Soth, Paul G. Leonard, Philip Jones, Pijus K. Mandal, Angela L. Harris, Martin R. Tremblay, Simon S. Yu, Jason P Burke, Connor A. Parker, Barbara Czako, Alessia Petrocchi, Naphtali J. Reyna, Joseph R. Marszalek, Matthew M. Hamilton, Timothy McAfoos, Brett W. Virgin-Downey, Graham Trevitt, Alfred Lammens, Alan Xu
Publikováno v:
Journal of Medicinal Chemistry. 64:11302-11329
Indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing enzyme that mediates the rate-limiting step in the metabolism of l-tryptophan to kynurenine, has been widely explored as a potential immunotherapeutic target in oncology. We developed a class of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec33cf6551a670d4d40eaab2894a6f60
https://doi.org/10.1021/acs.jmedchem.1c00679
https://doi.org/10.1021/acs.jmedchem.1c00679
Autor:
Michael J. Soth, Kang Le, Maria Emilia Di Francesco, Matthew M. Hamilton, Gang Liu, Jason P. Burke, Chris L. Carroll, Jeffrey J. Kovacs, Jennifer P. Bardenhagen, Christopher A. Bristow, Mario Cardozo, Barbara Czako, Elisa de Stanchina, Ningping Feng, Jill R. Garvey, Jason P. Gay, Mary K. Geck Do, Jennifer Greer, Michelle Han, Angela Harris, Zachary Herrera, Sha Huang, Virginia Giuliani, Yongying Jiang, Sarah B. Johnson, Troy A. Johnson, Zhijun Kang, Paul G. Leonard, Zhen Liu, Timothy McAfoos, Meredith Miller, Pietro Morlacchi, Robert A. Mullinax, Wylie S. Palmer, Jihai Pang, Norma Rogers, Charles M. Rudin, Hannah E. Shepard, Nakia D. Spencer, Jay Theroff, Qi Wu, Alan Xu, Ju Anne Yau, Giulio Draetta, Carlo Toniatti, Timothy P. Heffernan, Philip Jones
Publikováno v:
J Med Chem
Inhibition of glutaminase-1 (GLS-1) hampers the proliferation of tumor cells reliant on glutamine. Known glutaminase inhibitors have potential limitations, and in vivo exposures are potentially limited due to poor physicochemical properties. We initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b9f179f30ccdc7840fbbad768ec366
https://europepmc.org/articles/PMC9007139/
https://europepmc.org/articles/PMC9007139/
Autor:
Philip Jones, Timothy P. Heffernan, Natalya Nazarenko, Carlo Toniatti, Giulio Draetta, Anne Yau, Quanyun Xu, Jay Theroff, Nakia D. Spencer, Hannah Shepard, Norma Rogers, Jihai Pang, Wylie S. Palmer, Pietro Morlacchi, Meredith Miller, Timothy McAfoos, Zhen Liu, Zhijun Kang, Troy Johnson, Yongying Jiang, Sha Huang, Virginia Giuliani, Angela Harris, Mary Geck Do, Matthew M . Hamilton, Maria E. Di Francesco, Chris Carroll, Barbara Czako, Christopher Bristow, Jennifer Bardenhagen, Jason P. Burke, Jeffrey J. Kovacs, Gang Liu, Kang Le, Dr. Michael Soth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd6e4734b698474034c7af62ef1da54
https://doi.org/10.1021/scimeetings.0c03462
https://doi.org/10.1021/scimeetings.0c03462
Autor:
Paul G. Leonard, Richard T. Lewis, Mario Cardozo, Naphtali J. Reyna, Carlo Toniatti, Philip Jones, Alessia Petrocchi, Elisabetta Leo, Faika Mseeh, Matthew M. Hamilton, Xi Shi, Connor A. Parker, Giulio Draetta, Sha Huang, Jennifer Bardenhagen, Yongying Jiang, Cross Jason, Joseph R. Marszalek
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(6)
Structure based design of a novel class of aminopyrimidine MTH1 (MutT homolog 1) inhibitors is described. Optimization led to identification of IACS-4759 (compound 5), a sub-nanomolar inhibitor of MTH1 with excellent cell permeability and good metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258aa5f9430d59ca73b6027d966529a8
https://pubmed.ncbi.nlm.nih.gov/26898335
https://pubmed.ncbi.nlm.nih.gov/26898335
Autor:
Alessia Petrocchi, Naphtali J. Reyna, Faika Mseeh, Connor A. Parker, Simon Yu, Quanyun Xu, Ningping Feng, Paul Leonard, Norma Rogers, Jason B. Cross, Angela L. Harris, Yongying Jiang, Tin Oo Khor, Mikhila G. Mahendra, Jihai Pang, Qi Wu, Andy M. Zuniga, Timothy McAfoos, Matthew M. Hamilton, Joe R. Marszalek, Keith Mikule, Paul Vancutsem, Keith Wilcoxen, Martin Tremblay, Philip Jones, Richard T. Lewis
Publikováno v:
Cancer Research. 78:LB-071
Indoleamine 2,3-dioxygenase (IDO1 and IDO2) and tryptophan dioxygenase (TDO) are heme-containing enzymes that mediate the rate limiting step in the oxidative degradation of L-tryptophan (L-TRP) to kynurenine (KYN) metabolites. Tryptophan catabolism t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c0efdf3558a82bc49107b3bec62cbd8
https://doi.org/10.1158/1538-7445.am2018-lb-071
https://doi.org/10.1158/1538-7445.am2018-lb-071
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 24:227-235
Kinetic phosphorescence analysis (KPA) is a proven technique for rapid, precise, and accurate determination of uranium in aqueous solutions. Uranium analysis of biological samples require dry-ashing in a muffle furnace between 400 and 600 degrees C f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a7b01755f53ab9b3ea8df94866011a
https://doi.org/10.1016/s0731-7085(00)00412-x
https://doi.org/10.1016/s0731-7085(00)00412-x
Autor:
Larry D. Anderson, Katherine Squibb, Frank J. Hooper, James P. Keogh, Kathleen McPhaul, Lawrence Brown, Robert L. Kane, Belton A. Burrows, Michael Kabat, Melissa A. McDiarmid, David Jacobson-Kram, Raymond K. DiPino, Matthew M. Hamilton, Mark Walsh, Dennis Hoover, Bruce Kaup
Publikováno v:
Environmental Research. 82:168-180
A small group of Gulf War veterans possess retained fragments of depleted uranium (DU) shrapnel, the long-term health consequences of which are undetermined. We evaluated the clinical health effects of DU exposure in Gulf War veterans compared with n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c48a763ebf223ecff3973542db58cd7
https://doi.org/10.1006/enrs.1999.4012
https://doi.org/10.1006/enrs.1999.4012
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :2491-2494
Uranyl nitrate [UO2(NO3)2] (1.0 × 10–3M) is reacted with hydrogen peroxide (H2O2, 5 × 10–3M) in the presence of the spin trap 5,5-dimethyl-4,5-dihydro-3H-pyrrole N-oxide (DMPO, 5 × 10–2M) in acidic solutions. The reaction generates a 1∶2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bcbba295be3d97ff78a788a356fc253
https://doi.org/10.1039/a702509b
https://doi.org/10.1039/a702509b
Autor:
Andrzej Mazan, Naphtali J. Reyna, Faika Mseeh, Christian Dillon, Matthew M. Hamilton, Giulio Draetta, Maria Alimova, Jennifer Bardenhagen, Connor A. Parker, Edward Felix, Phil Jones, Alessia Petrocchi, Carlo Toniatti, Xi Shi, Richard T. Lewis, Joseph R. Marszalek, Elisabetta Leo
Publikováno v:
Molecular Cancer Therapeutics. 14:B48-B48
MTH1 is a protein that sanitizes oxidized dNTPs in the cell. It preferentially hydrolyzes 8-oxo-dGTP and 2-OH-dATP to their corresponding monophosphates and thereby prevents the incorporation of oxidized nucleotides into DNA or RNA. The functional re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::950f397cc413e25497ab1e1dd36c93bd
https://doi.org/10.1158/1535-7163.targ-15-b48
https://doi.org/10.1158/1535-7163.targ-15-b48
Publikováno v:
Medicine & Science in Sports & Exercise. 47:815
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e67687722960e074ee7d229bf825ad
https://doi.org/10.1249/01.mss.0000478962.40586.88
https://doi.org/10.1249/01.mss.0000478962.40586.88