Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Matthew M. Edwards"'
Autor:
Matthew M. Edwards, Ning Wang, Ido Sagi, Shay Kinreich, Nissim Benvenisty, Jeannine Gerhardt, Dieter Egli, Amnon Koren
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114700- (2024)
Summary: Genomic imprinting involves differential DNA methylation and gene expression between homologous paternal and maternal loci. It remains unclear, however, whether DNA replication also shows parent-of-origin-specific patterns at imprinted or ot
Externí odkaz:
https://doaj.org/article/2eb1152efe2f44a1a548ec7f56ff265b
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113664- (2024)
Summary: Induced pluripotent stem cells (iPSCs) are the foundation of cell therapy. Differences in gene expression, DNA methylation, and chromatin conformation, which could affect differentiation capacity, have been identified between iPSCs and embry
Externí odkaz:
https://doaj.org/article/91cd4c9d003a41d5a3af0ea2be01afdf
Autor:
Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu, Alexa N. Bracci, Michelle L. Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J. Charvet, Sulagna Ghosh, Robert E. Handsaker, Kevin Eggan, Florian T. Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G. Clark, Amnon Koren
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The genetic basis of how cells replicate their DNA is not well understood. Here, the authors identify >1000 genetic elements that control human replication and reveal a complex epigenetic system that regulates replication origin activities.
Externí odkaz:
https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
Autor:
Andrew L. H. Webster, Mathijs A. Sanders, Krupa Patel, Ralf Dietrich, Raymond J. Noonan, Francis P. Lach, Ryan R. White, Audrey Goldfarb, Kevin Hadi, Matthew M. Edwards, Frank X. Donovan, Remco M. Hoogenboezem, Moonjung Jung, Sunandini Sridhar, Tom F. Wiley, Olivier Fedrigo, Huasong Tian, Joel Rosiene, Thomas Heineman, Jennifer A. Kennedy, Lorenzo Bean, Rasim O. Rosti, Rebecca Tryon, Ashlyn-Maree Gonzalez, Allana Rosenberg, Ji-Dung Luo, Thomas S. Carroll, Sanjana Shroff, Michael Beaumont, Eunike Velleuer, Jeff C. Rastatter, Susanne I. Wells, Jordi Surrallés, Grover Bagby, Margaret L. MacMillan, John E. Wagner, Maria Cancio, Farid Boulad, Theresa Scognamiglio, Roger Vaughan, Kristin G. Beaumont, Amnon Koren, Marcin Imielinski, Settara C. Chandrasekharappa, Arleen D. Auerbach, Bhuvanesh Singh, David I. Kutler, Peter J. Campbell, Agata Smogorzewska
Publikováno v:
Nature, 612(7940), 495-502. Nature Publishing Group
Nature
Nature
Fanconi anaemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink repair resulting in chromosome breakage1–3. The FA repair pathway protects against endogenous and exogenous carcinogenic aldehydes4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15cd1011ef44b739a461beaa02a1cb6
https://doi.org/10.1038/s41586-022-05253-4
https://doi.org/10.1038/s41586-022-05253-4
Autor:
Joyce Hsiao, Ya Hu, Ning Wang, Amnon Koren, Andrew G. Clark, Alexa N. Bracci, Kevin Eggan, Florian T. Merkle, Michelle L Hulke, Matthew M. Edwards, Christine J. Charvet, Sulagna Ghosh, Dieter Egli, Qiliang Ding, Xiang Zhu, Robert E. Handsaker, Jeannine Gerhardt, Yao Tong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Funder: National Institute of Health (NIH) DP2-GM123495
DNA replication follows a strict spatiotemporal program that intersects with chromatin structure but has a poorly understood genetic basis. To systematically identify genetic regulators of
DNA replication follows a strict spatiotemporal program that intersects with chromatin structure but has a poorly understood genetic basis. To systematically identify genetic regulators of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e3ee93deb4806288d949931a0bc770
https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
https://doaj.org/article/35d8b329749043bfb83a3cd38e9be893
Autor:
Igor Segota, Matthew M Edwards, Arthur Campello, Brendan H Rappazzo, Xiaoning Wang, Ariana Strandburg-Peshkin, Xiao-Qiao Zhou, Archana Rachakonda, Kayvon Daie, Alexander Lussenhop, Sungsu Lee, Kevin Tharratt, Amrish Deshmukh, Elisabeth M Sebesta, Myron Zhang, Sharon Lau, Sarah Bennedsen, Jared Ginsberg, Timothy Campbell, Chenzheng Wang, Carl Franck
In studies of the unicellular eukaryote Dictyostelium discoideum, many have anecdotally observed that cell dilution below a certain ‘threshold density’ causes cells to undergo a period of slow growth (lag). However, little is documented about the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1f36d92f7f0810e2edca03589b6882
Autor:
Sunandini Sridhar, David I. Kutler, Bhuvanesh Singh, Susanne I. Wells, Ji-Dung Luo, Mathijs A. Sanders, Margaret L. MacMillan, Ashlyn-Maree Gonzalez, Lorenzo Bean, Rebecca Tryon, Huasong Tian, Jordi Surrallés, Arleen D. Auerbach, Kevin Hadi, Moonjung Jung, Ralf Dietrich, Matthew M. Edwards, Eunike Velleuer, Krupa R. Patel, Frank X. Donovan, Amnon Koren, Marcin Imielinski, Audrey Goldfarb, Ozgur Rosti, Jeffrey C. Rastatter, Theresa Scognamiglio, John E. Wagner, Andrew L.H. Webster, Maria Cancio, Olivier Fedrigo, Agata Smogorzewska, Jennifer A. Kennedy, Thomas Carrol, Grover C. Bagby, Joel Rosiene, Allana Rosenberg, Thomas Heineman, Ryan R. White, Raymond J. Noonan, Farid Boulad, Francis P. Lach, Settara C. Chandrasekharappa, Peter J. Campbell, Roger D. Vaughan
Fanconi anemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink (ICL) repair resulting in chromosome breakage1–3. The FA repair pathway comprises at least 22 FANC proteins including BRCA1 and BRCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9afd781051fca6c3cb7bdbe0af4e0c0
https://doi.org/10.1101/2021.08.14.456365
https://doi.org/10.1101/2021.08.14.456365
Autor:
Dan Vershkov, Matthew M. Edwards, Amnon Koren, Nissim Benvenisty, Qiliang Ding, Dieter Egli, Michael V. Zuccaro, Ido Sagi
Publikováno v:
Genome research.
Haploid human embryonic stem cells (ESCs) provide a powerful genetic system but diploidize at high rates. We hypothesized that diploidization results from aberrant DNA replication. To test this, we profiled DNA replication timing in isogenic haploid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6154c2c08c1c0da60ed4688644c7cc
https://pubmed.ncbi.nlm.nih.gov/34810218
https://pubmed.ncbi.nlm.nih.gov/34810218
Autor:
Andrew L. Webster, Mathijs A. Sanders, Krupa Patel, Ralf Dietrich, Raymond J. Noonan, Francis P. Lach, Ryan R. White, Audrey M. Goldfarb, Kevin Hadi, Matthew M. Edwards, Frank X. Donovan, Moonjung Jung, Sunandini Sridhar, Olivier Fedrigo, Huasong Tian, Joel Rosiene, Thomas Heineman, Jennifer Kennedy, Lorenzo Bean, Rasim O. Rosti, Rebecca Tryon, Ashlyn-Maree Gonzalez, Allana Rosenberg, Ji-Dung Luo, Thomas Carrol, Eunike Velleuer, Jeff C. Rastatter, Susanne I. Wells, Jordi Surrallés, Grover Bagby, Margaret L. MacMillan, John E. Wagner, Maria Cancio, Farid Boulad, Theresa Scognamiglio, Roger Vaughan, Amnon Koren, Marcin Imielinski, Settara Chandrasekharappa, Arleen D. Auerbach, Bhuvanesh Singh, David Kutler, Peter J. Campbell, Agata Smogorzewska
Publikováno v:
Cancer Research. 82:6196-6196
Fanconi anemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink (ICL) repair resulting in chromosome breakage. The FA repair pathway comprises at least 22 FANC proteins including BRCA1 and BRCA2 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93046854d732003d6d22f0ca29e784e7
https://doi.org/10.1158/1538-7445.am2022-6196
https://doi.org/10.1158/1538-7445.am2022-6196
Autor:
Igor, Segota, Matthew M, Edwards, Arthur, Campello, Brendan H, Rappazzo, Xiaoning, Wang, Ariana, Strandburg-Peshkin, Xiao-Qiao, Zhou, Archana, Rachakonda, Kayvon, Daie, Alexander, Lussenhop, Sungsu, Lee, Kevin, Tharratt, Amrish, Deshmukh, Elisabeth M, Sebesta, Myron, Zhang, Sharon, Lau, Sarah, Bennedsen, Jared, Ginsberg, Timothy, Campbell, Chenzheng, Wang, Carl, Franck
Publikováno v:
Physical biology. 19(2)
In studies of the unicellular eukaryote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3319333e729dec855e6d75ff50be9ef9
https://pubmed.ncbi.nlm.nih.gov/34942613
https://pubmed.ncbi.nlm.nih.gov/34942613