Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors

Autor: Victor J. Hruby, Bahar Tan, Minying Cai, Alexander V. Mayorov, James P. Cain, Erin S. Palmer, Matthew M. Dedek, Dev Trivedi, Dustin K. Tanaka

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:3099-3102

A novel hybrid melanocortin pharmacophore was designed based on the topographical similarities between the pharmacophores of Agouti related protein (AGRP) an endogenous melanocortin antagonist, and α-melanocyte-stimulating hormone (α-MSH), an endog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bc881439fa48b9cbe5ea551c4310cc
https://doi.org/10.1016/j.bmcl.2011.03.019

Design, Synthesis and Biological Evaluation of Ligands Selective for the Melanocortin-3 Receptor

Autor: null Matthew M. Dedek, null Devendra Trivedi, null James P. Cain, null Minying Cai, null Victor J. Hruby

Publikováno v: Current Topics in Medicinal Chemistry. 7:1085-1097

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::563a38d3cea4f79a38a50300dcf32c5c
https://doi.org/10.2174/156802607780906654

Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor

Autor: Minying Cai, Josef Vagner, Xuyuan Gu, Dev Trivedi, Victor J. Hruby, Matthew M. Dedek, Jinfa Ying

Publikováno v: Journal of medicinal chemistry. 49(23)

Intensive efforts have been made to develop potent and selective ligands for certain human melanocortin receptors as possible treatments for obesity and sexual dysfunction due to the role of these receptors in feeding behavior, energy homeostasis, se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e84895264934974a6b431ff2496c53
https://pubmed.ncbi.nlm.nih.gov/17154518

A Screening Test for HLA-B ^∗ 15:02 in a Large United States Patient Cohort Identifies Broader Risk of Carbamazepine-Induced Adverse Events.

Autor: Fang H; Millennium Health, San Diego, CA, United States., Xu X; Millennium Health, San Diego, CA, United States., Kaur K; Millennium Health, San Diego, CA, United States., Dedek M; Millennium Health, San Diego, CA, United States., Zhu GD; Millennium Health, San Diego, CA, United States., Riley BJ; Millennium Health, San Diego, CA, United States., Espin FG; Millennium Health, San Diego, CA, United States., Del Tredici AL; Millennium Health, San Diego, CA, United States., Moreno TA; Millennium Health, San Diego, CA, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2019 Mar 26; Vol. 10, pp. 149. Date of Electronic Publication: 2019 Mar 26 (Print Publication: 2019).

Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor.

Autor: Ying J; Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA., Gu X, Cai M, Dedek M, Vagner J, Trivedi DB, Hruby VJ

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2006 Nov 16; Vol. 49 (23), pp. 6888-96.