Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Matthew M Hathorn"'
Autor:
Ofer Feinerman, Garrit Jentsch, Karen E Tkach, Jesse W Coward, Matthew M Hathorn, Michael W Sneddon, Thierry Emonet, Kendall A Smith, Grégoire Altan‐Bonnet
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-16 (2010)
Abstract Understanding how the immune system decides between tolerance and activation by antigens requires addressing cytokine regulation as a highly dynamic process. We quantified the dynamics of interleukin‐2 (IL‐2) signaling in a population of
Externí odkaz:
https://doaj.org/article/662b3f76a4324301a3cabe5e7129ddcd
Autor:
Karen E Tkach, Debashis Barik, Guillaume Voisinne, Nicole Malandro, Matthew M Hathorn, Jesse W Cotari, Robert Vogel, Taha Merghoub, Jedd Wolchok, Oleg Krichevsky, Grégoire Altan-Bonnet
Publikováno v:
eLife, Vol 3 (2014)
Variability within isogenic T cell populations yields heterogeneous ‘local’ signaling responses to shared antigenic stimuli, but responding clones may communicate ‘global’ antigen load through paracrine messengers, such as cytokines. Such coo
Externí odkaz:
https://doaj.org/article/93b0bebb910d43acb92f2212db05dbe5
Autor:
Matthew M Hathorn, James P. Allison, Hélène Beuneu, Emily Corse, Rachel A. Gottschalk, Michael L. Dustin, Grégoire Altan-Bonnet
The strength of T-cell receptor (TCR) stimulation and subsequent T-cell response depend on a combination of peptide-major histocompatibility complex (pMHC) density and potency. By comparing two different pMHC at doses yielding similar proliferation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2006d44ebdf8f7a2d6ef0a3887e9fd01
https://doi.org/10.1073/pnas.1119763109
https://doi.org/10.1073/pnas.1119763109
Autor:
Matthew M Hathorn, Taha Merghoub, Nicole Malandro, Karen E Tkach, Oleg Krichevsky, Robert Vogel, Jesse W. Cotari, Guillaume Voisinne, Grégoire Altan-Bonnet, Debashis Barik, Jedd D. Wolchok
Publikováno v:
eLife, Vol 3 (2014)
eLife
eLife
Variability within isogenic T cell populations yields heterogeneous ‘local’ signaling responses to shared antigenic stimuli, but responding clones may communicate ‘global’ antigen load through paracrine messengers, such as cytokines. Such coo
Autor:
Taha Merghoub, Nicole Malandro, Oleg Krichevsky, Karen E Tkach, Grégoire Altan-Bonnet, Guillaume Voisinne, Jedd D. Wolchok, Robert Vogel, Jesse W. Cotari, Matthew M Hathorn, Debashis Barik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5635f8cd14f6925949b3eeab778dec7e
https://doi.org/10.7554/elife.01944.018
https://doi.org/10.7554/elife.01944.018
Autor:
Karen E Tkach, Thierry Emonet, Jesse Coward, Kendall A. Smith, Michael W. Sneddon, Garrit Jentsch, Grégoire Altan-Bonnet, Ofer Feinerman, Matthew M Hathorn
Publikováno v:
Molecular Systems Biology
The sensitivity of T cells to interleukin-2 (IL-2) can vary by three orders of magnitude and is determined by the surface densities of the IL-2 receptor α subunits. Regulatory T cells inflict a double hit on effector T cells by lowering the bulk IL-