Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Matthew M, Hayward"'
Autor:
James, Schiemer, Reto, Horst, Yilin, Meng, Justin I, Montgomery, Yingrong, Xu, Xidong, Feng, Kris, Borzilleri, Daniel P, Uccello, Carolyn, Leverett, Stephen, Brown, Ye, Che, Matthew F, Brown, Matthew M, Hayward, Adam M, Gilbert, Mark C, Noe, Matthew F, Calabrese
Publikováno v:
Nature chemical biology. 17(2)
Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a mechanism of growi
Autor:
Andrew, Fensome, Catherine M, Ambler, Eric, Arnold, Mary Ellen, Banker, Matthew F, Brown, Jill, Chrencik, James D, Clark, Martin E, Dowty, Ivan V, Efremov, Andrew, Flick, Brian S, Gerstenberger, Ariamala, Gopalsamy, Matthew M, Hayward, Martin, Hegen, Brett D, Hollingshead, Jason, Jussif, John D, Knafels, David C, Limburg, David, Lin, Tsung H, Lin, Betsy S, Pierce, Eddine, Saiah, Raman, Sharma, Peter T, Symanowicz, Jean-Baptiste, Telliez, John I, Trujillo, Felix F, Vajdos, Fabien, Vincent, Zhao-Kui, Wan, Li, Xing, Xiaojing, Yang, Xin, Yang, Liying, Zhang
Publikováno v:
Journal of medicinal chemistry. 61(19)
Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway. JAK1 is important for the γ-common chain
Autor:
Rebecca M. Roth, Kevin J. Duffy, Jiasheng Guo, Kirk L. Stevens, Yoshito Kishi, Peter I. Dalko, Matthew M. Hayward
Publikováno v:
Angewandte Chemie International Edition. 37:190-196
Autor:
Kevin J. Duffy, Jiasheng Guo, Yoshito Kishi, Kirk L. Stevens, Peter I. Dalko, Rebecca M. Roth, Matthew M. Hayward
Publikováno v:
Angewandte Chemie International Edition. 37:187-190
The most active compound of the extraordinarily cytotoxic spongipyrans, spongistatin 1, isolated from marine sponges, appeared to be identical to altohyrtin A. The total synthesis of this macrolide has now firmly established the relative and absolute
Autor:
Kevin J. Duffy, Rebecca M. Roth, Yoshito Kishi, Matthew M. Hayward, Peter I. Dalko, Jiasheng Guo, Kirk L. Stevens
Publikováno v:
Angewandte Chemie. 110:202-206
Auserordentlich cytotoxisch sind die aus Meeresschwammen isolierten Spongipyrane. Sie wirken gegen mehrere menschliche Krebszellinien, wobei das als erste Verbindung dieser Naturstoffklasse isolierte Spongistatin 1 am wirksamsten ist. Die erste Total
Autor:
Matthew M. Hayward, Rebecca M. Roth, Yoshito Kishi, Jiasheng Guo, Kirk L. Stevens, Peter I. Dalko, Kevin J. Duffy
Publikováno v:
ChemInform. 29
Autor:
Matthew M. Hayward
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783642010743
Lead-Seeking Approaches
Lead-Seeking Approaches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ef9ac09226c252ddb93f88628cfcafb
https://doi.org/10.1007/978-3-642-01075-0
https://doi.org/10.1007/978-3-642-01075-0
Autor:
Matthew M. Hayward
High quality leads provide the foundation for the discovery of successful clinical development candidates, and therefore the identi?cation of leads is an essential part of drug discovery. The process for the identi?cation of leads generally starts wi
Autor:
Sarah Bamford, Patricia M. Brennan, Evelyn J. Lajiness, Bruce R. Branching, Matthew M. Hayward
Publikováno v:
Photochemistry and photobiology. 49(5)
In the course of investigations on the possible involvement of the CIEEL (chemically initiated electron-exchange luminescence) mechanism in firefly bioluminescence, we have synthesized two novel firefly luciferin substrate analogues. D-Naphthyllucife
Autor:
Pucciarelli A; Department of Chiropractic, Faculty of Science and Engineering, Macquarie University., Randall N; Department of Chiropractic, Faculty of Science and Engineering, Macquarie University., Hayward M; Department of Chiropractic, Faculty of Science and Engineering, Macquarie University., Triantis J; Department of Chiropractic, Faculty of Science and Engineering, Macquarie University., Owen W; Department of Chiropractic, Faculty of Science and Engineering, Macquarie University., Swain M; Department of Chiropractic, Faculty of Science and Engineering, Macquarie University., de Luca K; Department of Chiropractic, Faculty of Science and Engineering, Macquarie University.
Publikováno v:
The Journal of the Canadian Chiropractic Association [J Can Chiropr Assoc] 2020 Dec; Vol. 64 (3), pp. 193-200.