Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Matthew Lombardo"'
Autor:
Dann L. Parker, Randal M. Bugianesi, Birgit T. Priest, Feroze Ujjainwalla, Edward C. Sherer, Stanley Mitelman, Sharon Tong, Matthew Lombardo, William K. Hagmann, Ravi P. Nargund, Melissa Costa, Christopher Joseph Sinz, Anka G. Ehrhardt, Scott D. Edmondson, Ravi Kurukulasuriya, Xiaofang Li, Karen H. Dingley, Kate Bender, Kevin S. Ratliff, Jonathan E. Wilson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2947-2951
A novel series of benzo-[1,2,4]-triazolo-[1,4]-oxazepine GPR142 agonists are described. The series was designed to address the suboptimal PK (pharmacokinetic) and off-target profile of a class of N-aryl-benzo-[1,4]-oxazepine-4-carboxamides, represent
Autor:
Matthew Lombardo, Eric N. Johnson, John Cummings, Jerry Di Salvo, Thomas Roussel, James R. Tata, Melissa Kirkland, Michael A. Plotkin, Christopher Joseph Sinz, Feroze Ujjainwalla, Dennis Leung, Dorina Trusca, Joel Mane, Taro E. Akiyama, Alejandro Crespo, Mary Ann Powles, Kate Bender, Michael F.A. Finley, Joanna Pols, Candice Alleyne, Michele Pachanski, Andrew D. Howard, Wayne M. Geissler, Ying Lei, Bahanu Habulihaz, Victor N. Uebele, Clare London, Maria Madeira
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(5)
Autor:
Christopher Joseph Sinz, Sarah Souza, Aimie M. Ogawa, Dennis Leung, Eric R. Ashley, Brande Thomas-Fowlkes, Maria Madeira, Mary Ann Powles, Effie Tozzo, Hong D. Chu, Feroze Ujjainwalla, Melissa Kirkland, Matthew Lombardo, Clare London, Jerry Di Salvo, Keith Eagen, John S. Debenham, Jason M. Cox, Ping Lan, Alejandro Crespo, Adam B. Weinglass, Taro E. Akiyama, Nengxue Wang, Henry M. Vaccaro, Michele Pachanski, Shah Unmesh G, Zhongxiang Sun, Mariappan V. Chelliah, James R. Tata, Michael A. Plotkin, Candice Alleyne, Takao Suzuki, Srikanth Venkatraman
Publikováno v:
ACS medicinal chemistry letters. 8(1)
Type 2 diabetes mellitus (T2DM) is an ever increasing worldwide epidemic, and the identification of safe and effective insulin sensitizers, absent of weight gain, has been a long-standing goal of diabetes research. G-protein coupled receptor 120 (GPR
Autor:
Christopher Joseph Sinz, Feroze Ujjainwalla, Joel Mane, Eric N. Johnson, John Cummings, Jerry Di Salvo, Michele Pachanski, Michael A. Plotkin, Joanna Pols, Taro E. Akiyama, Andrew D. Howard, Matthew Lombardo, James R. Tata, Maria Madeira, Ying Lei, Wayne M. Geissler, Victor N. Uebele, Michael F.A. Finley, Clare London, Candice Alleyne, Thomas Roussel, Kate Bender, Dennis Leung, Bahanu Habulihaz, Mary Ann Powles, Melissa Kirkland, Dorina Trusca, Alejandro Crespo
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(23)
The transformation of an aryloxybutanoic acid ultra high-throughput screening (uHTS) hit into a potent and selective series of G-protein coupled receptor 120 (GPR120) agonists is reported. uHTS hit 1 demonstrated an excellent rodent pharmacokinetic p
Autor:
Rose M. Cubbon, Kevin T. Chapman, Sunita Malkani, Edward A. O'Neill, Ruixiu Wang, Lihu Yang, Silvi Luell, James E. Thompson, Songnian Lin, Jeffrey J. Hale, Wen Xiao Zhang, Sander G. Mills, Ester Carballo-Jane, Matthew Lombardo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3238-3242
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas are described as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). These compounds demonstrate potent in vitro activity against the enzyme with IC(50) values as low as 15
Autor:
Kevin T. Chapman, Ruixiu Wang, Songnian Lin, Rose M. Cubbon, Sunita Malkani, James E. Thompson, Edward A. O'Neill, Lihu Yang, Jeffrey J. Hale, Wen Xiao Zhang, Sander G. Mills, Matthew Lombardo
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(22)
Several series of novel non-thiourea-containing aminopyrazine derivatives were designed based on the MK-2 inhibitors 1-(2-aminopyrazin-3-yl)methyl-2-thioureas. These compounds were synthesized and evaluated for their inhibitory activity against MK-2
Autor:
Matthew Lombardo
1f / Biographical monologue / Tea at Five captures the fiery spirit of Katherine Hepburn in a one-woman show that recounts her journey from a well-heeled Yankee childhood to winner of four Oscars. Ensconced at her beloved Fenwick home, Ms. Hepburn re
Autor:
Jeffrey J. Hale, Andreas Verras, Wayne M. Geissler, Margarita Garcia-Calvo, Zhu Shen, Matthew Lombardo, Ranabir SinhaRoy, Suoyu Xu, Xinchun Tong, Steven L. Colletti, Dan Xie, Urmi R. Bhatt, Zhicai Wu, Dong-Ming Shen, Shirly Pinto, Renee M. Chabin, Qing Chen, Mike E. Lassman, James R. Tata, Yusheng Xiong, Zhe Feng, Cangming Yang
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(4)
Efforts to modify the central proline portion of lead compound 4 lead to the discovery of novel prolylcarboxypeptidase (PrCP) inhibitors. Especially, replacement with alanine afforded compound 19 displaying more potent human and mouse PrCP inhibitory