Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Matthew Lefebre"'
Publikováno v:
mBio, Vol 5, Iss 3 (2014)
ABSTRACT Motility is essential for the pathogenesis of many bacterial species. Most bacteria move using flagella, which are multiprotein filaments that rotate propelled by a cell wall-anchored motor using chemical energy. Although some components of
Externí odkaz:
https://doaj.org/article/0f206e26069448bb8de32c1d149d59bb
Autor:
Howard C. Hang, Jordan RoseFigura, Wing Lam, Jorge E. Galán, Lun K. Tsou, Zhenrun J. Zhang, Yen Chih Wang, Fulan Guan, Paul D. Dossa, Junya Kato, Maria Lara-Tejero, Matthew Lefebre, Yung-Chi Cheng, Jacob S. Yount
Publikováno v:
Journal of the American Chemical Society. 138:2209-2218
Traditional Chinese Medicines (TCMs) have been historically used to treat bacterial infections. However, the molecules responsible for these anti-infective properties and their potential mechanisms of action have remained elusive. Using a high-throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4b53442ac24a9e2c90f6dea420b830
https://doi.org/10.1021/jacs.5b11575
https://doi.org/10.1021/jacs.5b11575
Publikováno v:
Journal of Bacteriology. 197:3007-3014
Many bacterial pathogens and symbionts utilize type III secretion systems to interact with their hosts. These machines have evolved to deliver bacterial effector proteins into eukaryotic target cells to modulate a variety of cellular functions. One o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883ef8de9332d61fe132eaa8f0d8cac7
https://doi.org/10.1128/jb.00434-15
https://doi.org/10.1128/jb.00434-15
Autor:
Thenmalarchelvi Rathinavelan, Da-Chuan Guo, Srirupa Chatterjee, Andrew C. McShan, Roberto N. De Guzman, Jorge E. Galán, Chun Tang, Maria Lara-Tejero, Matthew Lefebre
Publikováno v:
Journal of Molecular Biology. 426:2958-2969
Salmonella and other pathogenic bacteria use the type III secretion system (T3SS) to inject virulence proteins into human cells to initiate infections. The structural component of the T3SS contains a needle and a needle tip. The needle is assembled f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d561b0c9ce6ff9bd19bb8db2661e2905
https://doi.org/10.1016/j.jmb.2014.06.009
https://doi.org/10.1016/j.jmb.2014.06.009
Autor:
Matthew Lefebre, Jorge E. Galán
Publikováno v:
Proceedings of the National Academy of Sciences. 111:817-822
Type III secretion machines are essential for the biology of many bacteria that are pathogenic or symbiotic for animals, plants, or insects. They exert their function by delivering bacterial effector proteins into target eukaryotic cells. The core co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf46b9603fa4926909da009d5f92af3
https://doi.org/10.1073/pnas.1319698111
https://doi.org/10.1073/pnas.1319698111
Autor:
Jorge E. Galán, Samuel Wagner, Maria Lara-Tejero, Matthew Lefebre, Lisa Königsmaier, Thomas C. Marlovits
Publikováno v:
Proceedings of the National Academy of Sciences. 107:17745-17750
Type III protein secretion systems are unique bacterial nanomachines with the capacity to deliver bacterial effector proteins into eukaryotic cells. These systems are critical to the biology of many pathogenic or symbiotic bacteria for insects, plant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a9a9873609992ff49de4e22d3d396e
https://doi.org/10.1073/pnas.1008053107
https://doi.org/10.1073/pnas.1008053107
Autor:
Matthew Lefebre, Samuel Wagner, York-Dieter Stierhof, Julia V. Monjarás Feria, Jorge E. Galán
Publikováno v:
mBio
mBio, Vol 6, Iss 5 (2015)
mBio, Vol 6, Iss 5 (2015)
Type III secretion systems (T3SSs) are multiprotein machines employed by many Gram-negative bacteria to inject bacterial effector proteins into eukaryotic host cells to promote bacterial survival and colonization. The core unit of T3SSs is the needle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4c29c02127a93b5940b97233eac44b
https://pubmed.ncbi.nlm.nih.gov/26463164
https://pubmed.ncbi.nlm.nih.gov/26463164
Autor:
Susan M. Lea, Melanie A. Mcdowell, Roberto N. De Guzman, Courtney Gdowski, Matthew Lefebre, Yu Wang, Kawaljit Kaur, Stephen H. Benedict, Sunhwan Jo, Jorge E. Galán, Dalian Zhong
Publikováno v:
The Journal of biological chemistry. 287(30)
The type III secretion system (T3SS) is essential in the pathogenesis of many bacteria. The inner rod is important in the assembly of the T3SS needle complex. However, the atomic structure of the inner rod protein is currently unknown. Based on compu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48db3d28902a0015301ec8263f4b6058
http://ora.ox.ac.uk/objects/uuid:a5fe7553-f610-4d32-9508-6ce29e6124bb
http://ora.ox.ac.uk/objects/uuid:a5fe7553-f610-4d32-9508-6ce29e6124bb
Topology and Organization of the Salmonella typhimurium Type III Secretion Needle Complex Components
Autor:
Wolfgang H. Schmied, Oliver Schraidt, Jorge E. Galán, Matthias J. Brunner, Matthew Lefebre, Julia Radics, Andreas Schmidt, Thomas C. Marlovits, Karl Mechtler
Publikováno v:
PLoS Pathogens, Vol 6, Iss 4, p e1000824 (2010)
PLoS Pathogens
PLoS Pathogens
The correct organization of single subunits of multi-protein machines in a three dimensional context is critical for their functionality. Type III secretion systems (T3SS) are molecular machines with the capacity to deliver bacterial effector protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1caa525cc4b5f71262956e14b4a05c
https://doi.org/10.1371/journal.ppat.1000824
https://doi.org/10.1371/journal.ppat.1000824