Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Matthew L. Wheeler"'
Autor:
Julie A. Zorn, Matthew L. Wheeler, Ralston M. Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y.-C. Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M. West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract T-cell engagers (TCEs) are a growing class of biotherapeutics being investigated in the clinic for treatment of a variety of hematological and solid tumor indications. However, preclinical evaluation of TCEs in vivo has been mostly limited t
Externí odkaz:
https://doaj.org/article/3a2265c1ac814c838bd81c163786a89d
Autor:
Feng Wang, Jordan C. Tsai, Jonathan H. Davis, Bryant Chau, Jia Dong, Sean M. West, Jason M. Hogan, Matthew L. Wheeler, Christine Bee, Winse Morishige, Thomas Cayton, Donata David-brown, Chengyue Zhang, Alexander Kozhich, Tim Sproul, Gavin Dollinger, Arvind Rajpal, Pavel Strop
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provid
Externí odkaz:
https://doaj.org/article/f8bc83b729b6455e90c4ca6aa57051c9
Autor:
Kurosh Ameri, Arman Jahangiri, Anthony M. Rajah, Kathryn V. Tormos, Ravi Nagarajan, Melike Pekmezci, Vien Nguyen, Matthew L. Wheeler, Michael P. Murphy, Timothy A. Sanders, Stefanie S. Jeffrey, Yerem Yeghiazarians, Paolo F. Rinaudo, Joseph F. Costello, Manish K. Aghi, Emin Maltepe
Publikováno v:
Cell Reports, Vol 10, Iss 6, Pp 891-899 (2015)
Hypoxia-inducible gene domain family member 1A (HIGD1A) is a survival factor induced by hypoxia-inducible factor 1 (HIF-1). HIF-1 regulates many responses to oxygen deprivation, but viable cells within hypoxic perinecrotic solid tumor regions frequen
Externí odkaz:
https://doaj.org/article/073f933d7346420aa940bda4e626e3d6
Autor:
Erin Meermeier, Caleb K Stein, Meaghen E Sharik, Yuan Xiao Zhu, Megan T Du, Seth J Welsh, Chang-Xin Shi, Matthew L Wheeler, P. Leif Bergsagel, Marta Chesi
Publikováno v:
Blood. 140:7056-7057
Autor:
Julie A. Zorn, Matthew L. Wheeler, Ralston M. Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y.-C. Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M. West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop
Publikováno v:
Scientific reports. 12(1)
T-cell engagers (TCEs) are a growing class of biotherapeutics being investigated in the clinic for treatment of a variety of hematological and solid tumor indications. However, preclinical evaluation of TCEs in vivo has been mostly limited to xenogra
Autor:
Seeun Oh, Kai Li, Alexander Prince, Matthew L. Wheeler, Hussein Hamade, Christopher Nguyen, Kathrin S. Michelsen, David M. Underhill
Publikováno v:
Cell reports. 38(13)
Dectin-1 recognizes β-glucan in fungal cell walls, and activation of Dectin-1 in dendritic cells (DCs) influences immune responses against fungi. Although many studies have shown that DCs activated via Dectin-1 induce different subsets of T helper c
Autor:
Pavel Strop, P. Leif Bergsagel, Marta Chesi, Megan T. Du, Matthew L. Wheeler, Bryant Chau, Victoria M. Garbitt, Marco Bergsagel, Natalie Bezman, Caleb K. Stein, Chang-Xin Shi, Meaghen E. Sharik, Feng Wang, Daniel L. Riggs, Erin W. Meermeier, Seth J. Welsh
Publikováno v:
Blood Cancer Discov
BCMA/CD3-targeting bispecific antibodies (BsAb) are a recently developed immunotherapy class that shows potent tumor killing activity in multiple myeloma. Here, we investigated a murine BCMA/CD3-targeting BsAb in the immunocompetent Vk*MYC model and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb9f36adc448e13bc6a0a5e8f268bc3
https://europepmc.org/articles/PMC8266040/
https://europepmc.org/articles/PMC8266040/
Autor:
Feng Wang, Bryant Chau, Jia Dong, Olafur S. Gudmundsson, Yun Wang, Robert Langish, Pavel Strop, Matthew L. Wheeler, Arvind Rajpal, Winse Morishige, Guodong Chen, Natalie Bezman, Richard Y.-C. Huang
Publikováno v:
Analytical chemistry. 92(15)
Bispecific antibodies (BsAbs), with a unique mechanism of recognizing two different epitopes or antigens, have shown potential in various therapeutic areas. Molecular characterization of BsAbs' epitopes not only allows for detailed understanding of t
Autor:
Pavel Strop, Feng Wang, Donata David-brown, Bryant Chau, Christine Bee, Jordan C Tsai, Alexander T. Kozhich, Arvind Rajpal, Jason M. Hogan, Sean M. West, Thomas Cayton, Jia Dong, Tim Sproul, Winse Morishige, Matthew L. Wheeler, Jonathan H Davis, Chengyue Zhang, Gavin Dollinger
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provid
Publikováno v:
Annual Review of Pathology: Mechanisms of Disease. 12:359-385
Fungi are ubiquitous in our environment, and a healthy immune system is essential to maintain adequate protection from fungal infections. When this protection breaks down, superficial and invasive fungal infections cause diseases that range from irri