Molecular Insight into the Mg2+ -Dependent Allosteric Control of Indole Prenylation by Aromatic Prenyltransferase AmbP1

Autor: Ikuro Abe, Xinyu Liu, Yu Nakashima, Takayoshi Awakawa, Takahiro Mori, Rui Zhai, Chin Piow Wong, Matthew L. Hillwig

Publikováno v: Angewandte Chemie International Edition. 57:6810-6813

AmbP1 is a cyanobacterial aromatic prenyltransferase and a dedicated synthase for (R)-3-geranyl-3-isocyanovinyl indolenine (2), the biogenetic precursor for hapalindole-type alkaloids. The regioselective geranylation of cis-indolyl vinyl isonitrile (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ffdb09fb3286c842c308715d0d029b
https://doi.org/10.1002/anie.201800855

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

Autor: A.J. Mitchell, A.K. Boal, Ailiena O. Maggiolo, Nikhil R Ananth, Xinyu Liu, Qin Zhu, Matthew L. Hillwig

Publikováno v: Nature chemical biology

A 2.4-Å-resolution x-ray crystal structure of the carrier-protein independent halogenase, WelO5, in complex with its welwitindolinone precursor substrate, 12-epi-fischerindole U, reveals that the C13 chlorination target is proximal to the anticipate

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http://europepmc.org/articles/PMC5391150

Unified biogenesis of ambiguine, fischerindole, hapalindole and welwitindolinone: identification of a monogeranylated indolenine as a cryptic common biosynthetic intermediate by an unusual magnesium-dependent aromatic prenyltransferase

Autor: Matthew L. Hillwig, Leonardus M. I. Koharudin, Angela M. Gronenborn, Xinyu Liu

Publikováno v: Chemical Communications. 52:1737-1740

Biochemical characterization of aromatic prenyltransferase AmbP1 and its close homologs WelP1/FidP1 in hapalindole-type alkaloid biosynthetic pathways is reported. These enzymes mediate the magnesium-dependent selective formation of 3-geranyl 3-isocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23489b679bac76efdcf679b9f82387f0
https://doi.org/10.1039/c5cc10060g

Minimum Information about a Biosynthetic Gene cluster

Autor: Patrick Caffrey, Renzo Kottmann, Eriko Takano, Sean Doyle, Axel A. Brakhage, Matthew Cummings, Juan Pablo Gomez-Escribano, Yvonne Mast, Ryan F. Seipke, Rob Lavigne, Markus Nett, Hans-Wilhelm Nützmann, Jan Claesen, David H. Sherman, Daniel Petras, Pablo Cruz-Morales, Carl J. Balibar, Anne Osbourn, Oscar P. Kuipers, Leonilde M. Moreira, Xinyu Liu, Marcia S. Osburne, Bohdan Ostash, David P. Fewer, Changsheng Zhang, Pelin Yilmaz, Mohamed S. Donia, Anja Greule, Hyun Uk Kim, Nicholas J. Tobias, Frank Oliver Glöckner, Christoph Geiger, Chia Y. Lee, William H. Gerwick, Philipp Wiemann, Bertolt Gust, Susan E. Jensen, Wilfred A. van der Donk, Jan Kormanec, Ben Shen, Christopher M. Thomas, Jason Micklefield, Srikanth Duddela, R. Cameron Coates, René De Mot, Anthony S. Haines, Neha Garg, Guohui Pan, Roderich D. Süssmuth, Hyung Jin Kwon, Jonathan D. Walton, Lena Gerwick, Jörn Piel, Monika Ehling-Schulz, Zhenhua Tian, Jonathan L. Klassen, Xiaohui Yan, Emily A. Monroe, Yunchang Xie, Russell J. Cox, Keishi Ishida, Grace Yim, Stefano Donadio, Nadine Ziemert, Yuta Tsunematsu, Matthew L. Hillwig, Miroslav Petricek, Sylvie Lautru, Tilmann Weber, Andrew W. Truman, Rainer Breitling, Peter Kötter, Nikos C. Kyrpides, Stephanie Düsterhus, Christian Hertweck, Hideaki Oikawa, Sean F. Brady, Christopher T. Walsh, Adam C. Jones, Marcus A. Moore, Bradley S. Moore, Barrie Wilkinson, Simone M. Mantovani, Nathan A. Moss, Elizabeth E. Wyckoff, Emily P. Balskus, Kapil Tahlan, Fengan Yu, Monica Höfte, Jos M. Raaijmakers, Taifo Mahmud, Yit-Heng Chooi, Yi Tang, Andreas Bechthold, Douglas A. Mitchell, Joanne M. Willey, Helge B. Bode, John B. Biggins, Margherita Sosio, Yi-Qiang Cheng, Carmen Méndez, Leonard Kaysser, Joleen Masschelein, Daniel Krug, Federico Rosconi, Marnix H. Medema, Kaarina Sivonen, Tomohisa Kuzuyama, Mikko Metsä-Ketelä, Esther K. Schmitt, Carsten Kegler, Andriy Luzhetskyy, Gilles P. van Wezel, Bai Linquan, Kai Blin, Jens Nielsen, Bertrand Aigle, Amrita Pati, Harald Gross, Muriel Viaud, Pieter C. Dorrestein, Carla S. Jones, Michael A. Fischbach, Shelley M. Payne, Zhe Rui, Gerard D. Wright, Wen Liu, Alexey V. Melnik, Barry Scott, Brett A. Neilan, Nancy P. Keller, Rainer Borriss, Katrin Jungmann, Michalis Hadjithomas, Evi Stegmann, Daniel J. Edwards, F. Jerry Reen, Alexander Kristian Apel, Wolfgang Wohlleben, Michael J. Smanski, Leonard Katz, Fergal O'Gara, Eric J. N. Helfrich, Sergey B. Zotchev, Olivier Ploux, Arnold J. M. Driessen, Rolf Müller, Jean-Luc Pernodet, K. D. Entian, José A. Salas, Irene de Bruijn, Francisco Barona-Gómez, Jianhua Ju, Jon Clardy

Publikováno v: Nature Chemical Biology, 11(9), 625-631. Nature Publishing Group
Nature Chemical Biology 11 (2015), Nr. 9
Medema, M H, Kottmann, R, Yilmaz, P, Cummings, M, Biggins, J B, Blin, K, Bruijn, I D, Chooi, Y H, Claesen, J, Coates, R C, Cruz-Morales, P, Duddela, S, Düsterhus, S, Edwards, D J, Fewer, D P, Garg, N, Geiger, C, Gomez-Escribano, J P, Greule, A, Hadjithomas, M, Haines, A S, Helfrich, E J N, Hillwig, M L, Ishida, K, Jones, A C, Jones, C S, Jungmann, K, Kegler, C, Kim, H U, Kötter, P, Krug, D, Masschelein, J, Melnik, A V, Mantovani, S M, Monroe, E A, Moore, M, Moss, N, Nützmann, H-W, Pan, G, Pati, A, Petras, D, Reen, F J, Rosconi, F, Rui, Z, Tian, Z, Tobias, N J, Tsunematsu, Y, Wiemann, P, Wyckoff, E, Yan, X, Yim, G, Yu, F, Xie, Y, Aigle, B, Apel, A K, Balibar, C J, Balskus, E P, Barona-Gómez, F, Bechthold, A, Bode, H B, Borriss, R, Brady, S F, Brakhage, A A, Caffrey, P, Cheng, Y-Q, Clardy, J, Cox, R J, Mot, R D, Donadio, S, Donia, M S, Donk, W A V D, Dorrestein, P C, Doyle, S, Driessen, A J M, Ehling-Schulz, M, Entian, K-D, Fischbach, M A, Gerwick, L, Gerwick, W H, Gross, H, Gust, B, Hertweck, C, Höfte, M, Jensen, S E, Ju, J, Katz, L, Kaysser, L, Klassen, J L, Keller, N P, Kormanec, J, Kuipers, O P, Kuzuyama, T, Kyrpides, N C, Kwon, H-J, Lautru, S, Lavigne, R, Lee, C Y, Linquan, B, Liu, X, Liu, W, Luzhetskyy, A, Mahmud, T, Mast, Y, Méndez, C, Metsä-Ketelä, M, Micklefield, J, Mitchell, D A, Moore, B S, Moreira, L M, Müller, R, Neilan, B A, Nett, M, Nielsen, J, O'Gara, F, Oikawa, H, Osbourn, A, Osburne, M S, Ostash, B, Payne, S M, Pernodet, J-L, Petricek, M, Piel, J, Ploux, O, Raaijmakers, J M, Salas, J A, Schmitt, E K, Scott, B, Seipke, R F, Shen, B, Sherman, D H, Sivonen, K, Smanski, M J, Sosio, M, Stegmann, E, Süssmuth, R D, Tahlan, K, Thomas, C M, Tang, Y, Truman, A W, Viaud, M, Walton, J D, Walsh, C T, Weber, T, Wezel, G P V, Wilkinson, B, Willey, J M, Wohlleben, W, Wright, G D, Ziemert, N, Zhang, C, Zotchev, S B, Breitling, R, Takano, E & Glöckner, F O 2015, ' Minimum Information about a Biosynthetic Gene cluster ', Nature chemical biology, vol. 11, pp. 625-631 . https://doi.org/10.1038/nchembio.1890
Medema, M H, Kottmann, R, Yilmaz, P, Cummings, M, Biggins, J B, Blin, K, de Bruijn, I, Kim, H U, Nielsen, J & Weber, T 2015, ' Minimum Information about a Biosynthetic Gene cluster ', Nature Chemical Biology, vol. 11, no. 9, pp. 625-631 . https://doi.org/10.1038/nchembio.1890
ResearcherID
Nature Chemical Biology
Nature Chemical Biology, 2015, 11 (9), pp.625-31. ⟨10.1038/nchembio.1890⟩
Nature Chemical Biology, Nature Publishing Group, 2015, 11 (9), pp.625-31. ⟨10.1038/nchembio.1890⟩
Nature Chemical Biology, 11(9), 625-631
Nature Chemical Biology 11 (2015) 9
Scopus
Medema, M H, Kottmann, R, Yilmaz, P, Cummings, M, Biggins, J B, Blin, K, Bruijn, I D, Chooi, Y H, Claesen, J, Coates, R C, Cruz-Morales, P, Duddela, S, Düsterhus, S, Edwards, D J, Fewer, D P, Garg, N, Geiger, C, Gomez-Escribano, J P, Greule, A, Hadjithomas, M, Haines, A S, Helfrich, E J N, Hillwig, M L, Ishida, K, Jones, A C, Jones, C S, Jungmann, K, Kegler, C, Kim, H U, Kötter, P, Krug, D, Masschelein, J, Melnik, A V, Mantovani, S M, Monroe, E A, Moore, M, Moss, N, Nützmann, H-W, Pan, G, Pati, A, Petras, D, Reen, F J, Rosconi, F, Rui, Z, Tian, Z, Tobias, N J, Tsunematsu, Y, Wiemann, P, Wyckoff, E, Yan, X, Yim, G, Yu, F, Xie, Y, Aigle, B, Apel, A K, Balibar, C J, Balskus, E P, Barona-Gómez, F, Bechthold, A, Bode, H B, Borriss, R, Brady, S F, Brakhage, A A, Caffrey, P, Cheng, Y-Q, Clardy, J, Cox, R J, Mot, R D, Donadio, S, Donia, M S, Donk, W A V D, Dorrestein, P C, Doyle, S, Driessen, A J M, Ehling-Schulz, M, Entian, K-D, Fischbach, M A, Gerwick, L, Gerwick, W H, Gross, H, Gust, B, Hertweck, C, Höfte, M, Jensen, S E, Ju, J, Katz, L, Kaysser, L, Klassen, J L, Keller, N P, Kormanec, J, Kuipers, O P, Kuzuyama, T, Kyrpides, N C, Kwon, H-J, Lautru, S, Lavigne, R, Lee, C Y, Linquan, B, Liu, X, Liu, W, Luzhetskyy, A, Mahmud, T, Mast, Y, Méndez, C, Metsä-Ketelä, M, Micklefield, J, Mitchell, D A, Moore, B S, Moreira, L M, Müller, R, Neilan, B A, Nett, M, Nielsen, J, O'Gara, F, Oikawa, H, Osbourn, A, Osburne, M S, Ostash, B, Payne, S M, Pernodet, J-L, Petricek, M, Piel, J, Ploux, O, Raaijmakers, J M, Salas, J A, Schmitt, E K, Scott, B, Seipke, R F, Shen, B, Sherman, D H, Sivonen, K, Smanski, M J, Sosio, M, Stegmann, E, Süssmuth, R D, Tahlan, K, Thomas, C M, Tang, Y, Truman, A W, Viaud, M, Walton, J D, Walsh, C T, Weber, T, Wezel, G P V, Wilkinson, B, Willey, J M, Wohlleben, W, Wright, G D, Ziemert, N, Zhang, C, Zotchev, S B, Breitling, R, Takano, E & Glöckner, F O 2015, ' Minimum Information about a Biosynthetic Gene cluster ' Nature chemical biology, vol. 11, pp. 625-631 . https://doi.org/10.1038/nchembio.1890
Nature Chemical Biology, Nature Publishing Group, 2015, 11 (9), pp.625-31. 〈10.1038/nchembio.1890〉
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

M.H.M. was supported by a Rubicon fellowship of the Netherlands Organization for Scientific Research (NWO;Rubicon 825.13.001). The work of R.K. was supported by the European Union’s Seventh Framework Programme(Joint Call OCEAN.2011–2: Marine micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d1aa4fd11e7fd63b1669a0f6239bbd
https://doi.org/10.1038/nchembio.1890

Characterization of an Orphan Diterpenoid Biosynthetic Operon from Salinispora arenicola

Autor: Mollie S. Tiernan, Bradley S. Moore, Amy L. Lane, Matthew L. Hillwig, Meimei Xu, Reuben J. Peters

Publikováno v: Journal of Natural Products

While more commonly associated with plants than microbes, diterpenoid natural products have been reported to have profound effects in marine microbe–microbe interactions. Intriguingly, the genome of the marine bacterium Salinispora arenicola CNS-20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92402d0c2a994d4de0d9f0920f878323
http://europepmc.org/articles/PMC4176389