Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Matthew L. Edin"'
Autor:
Charlotte Hateley, Antoni Olona, Laura Halliday, Matthew L. Edin, Jeong-Hun Ko, Roberta Forlano, Ximena Terra, Fred B. Lih, Raúl Beltrán-Debón, Penelopi Manousou, Sanjay Purkayastha, Krishna Moorthy, Mark R. Thursz, Guodong Zhang, Robert D. Goldin, Darryl C. Zeldin, Enrico Petretto, Jacques Behmoaras
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105127- (2024)
Summary: Background: Obesity drives maladaptive changes in the white adipose tissue (WAT) which can progressively cause insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated liver disease (MASLD). Obesity-mediated l
Externí odkaz:
https://doaj.org/article/f522db65b00f4ac6b5690aad31edc432
Autor:
Lanie A. Williams, Matthew C. Hamilton, Matthew L. Edin, Fred B. Lih, Jazmine A. Eccles-Miller, Nishanth Tharayil, Elizabeth Leonard, William S. Baldwin
Publikováno v:
Toxics, Vol 12, Iss 2, p 106 (2024)
Perfluorooctanesulfonate (PFOS) is a widespread environmental pollutant with a long half-life and clearly negative outcomes on metabolic diseases such as fatty liver disease and diabetes. Male and female Cyp2b-null and humanized CYP2B6-transgenic (hC
Externí odkaz:
https://doaj.org/article/c3a5bf7bc665410d9bd1806137db76a4
Autor:
Deanna K. Sosnowski, K. Lockhart Jamieson, Ahmed M. Darwesh, Hao Zhang, Hedieh Keshavarz-Bahaghighat, Robert Valencia, Anissa Viveiros, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, John M. Seubert
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveMetabolites derived from N−3 and N−6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated mitochondrial d
Externí odkaz:
https://doaj.org/article/61ddb9d2de3445089431a52f40b77b22
Autor:
Melissa V. Chan, Melissa A. Hayman, Suthesh Sivapalaratnam, Marilena Crescente, Harriet E. Allan, Matthew L. Edin, Darryl C. Zeldin, Ginger L. Milne, Jonathan Stephens, Daniel Greene, Moghees Hanif, Valerie B. O'Donnell, Liang Dong, Michael G. Malkowski, Claire Lentaigne, Katherine Wedderburn, Matthew Stubbs, Kate Downes, Willem H. Ouwehand, Ernest Turro, NIHR BioResource, Daniel P. Hart, Kathleen Freson, Michael A. Laffan, Timothy D. Warner
Publikováno v:
Haematologica, Vol 106, Iss 5 (2020)
We have identified a rare missense variant on chromosome 9, position 125145990 (GRCh37), in exon 8 in PTGS1 (the gene encoding cyclo-oxygenase 1, COX-1, the target of anti-thrombotic aspirin therapy). We report that in the homozygous state within a l
Externí odkaz:
https://doaj.org/article/67d8336da71a4f9fa0252ac3ddc88ca1
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Previously, we showed vascular endothelial overexpression of human-CYP2J2 enhances coronary reactive hyperemia in Tie2-CYP2J2 Tr mice, and eNOS−/− mice had overexpression of CYP2J-epoxygenase with adenosine A2A receptor-induced enhance relaxation
Externí odkaz:
https://doaj.org/article/639a48947b044217a1b548b4afd9c422
Autor:
Yan Gong, Zhuo Shao, Zhongjie Fu, Matthew L. Edin, Ye Sun, Raffael G. Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Samuel B. Burnim, Steven S. Meng, Fred B. Lih, John Paul SanGiovanni, Darryl C. Zeldin, Ann Hellström, Lois E.H. Smith
Publikováno v:
EBioMedicine, Vol 13, Iss C, Pp 201-211 (2016)
Neovascular eye diseases including retinopathy of prematurity, diabetic retinopathy and age-related-macular-degeneration are major causes of blindness. Fenofibrate treatment in type 2 diabetes patients reduces progression of diabetic retinopathy inde
Externí odkaz:
https://doaj.org/article/9ac54728e7dc4d9d8242e2c51cca0289
Autor:
Amy R. Johnson, Yuanyuan Qin, Alyssa J. Cozzo, Alex J. Freemerman, Megan J. Huang, Liyang Zhao, Brante P. Sampey, J. Justin Milner, Melinda A. Beck, Blossom Damania, Naim Rashid, Joseph A. Galanko, Douglas P. Lee, Matthew L. Edin, Darryl C. Zeldin, Patrick T. Fueger, Brittney Dietz, Andreas Stahl, Ying Wu, Karen L. Mohlke, Liza Makowski
Publikováno v:
Molecular Metabolism, Vol 5, Iss 7, Pp 506-526 (2016)
Objective: A novel approach to regulate obesity-associated adipose inflammation may be through metabolic reprogramming of macrophages (MΦs). Broadly speaking, MΦs dependent on glucose are pro-inflammatory, classically activated MΦs (CAM), which co
Externí odkaz:
https://doaj.org/article/3500912ba36c44dabe717f2ead379674
Autor:
Akinyemi Oni-Orisan, Matthew L. Edin, John Andrew Lee, Michael A. Wells, Erin S. Christensen, Kimberly C. Vendrov, Fred B. Lih, Kenneth B. Tomer, Xue Bai, Joan M. Taylor, George A. Stouffer, Darryl C. Zeldin, Craig R. Lee
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 1, Pp 109-119 (2016)
Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) exhibit potent cardiovascular protective effects in preclinical models, and promoting the effects of EETs has emerged as a potential therapeutic strategy for coronary artery disease (CAD)
Externí odkaz:
https://doaj.org/article/4f2cb1647d1e4547a04094c60e98c261
Autor:
Matthew L. Edin, Fred B. Lih, Bruce D. Hammock, Scott Thomson, Darryl C. Zeldin, David Bishop-Bailey
Publikováno v:
Cells, Vol 9, Iss 5, p 1096 (2020)
A number of oxylipins have been described as endogenous PPAR ligands. The very short biological half-lives of oxylipins suggest roles as autocrine or paracrine signaling molecules. While coronary arterial atherosclerosis is the root of myocardial inf
Externí odkaz:
https://doaj.org/article/b8c261ebb6ad43179ebea280a5592a71
Autor:
Weibin Zha, Matthew L. Edin, Kimberly C. Vendrov, Robert N. Schuck, Fred B. Lih, Jawahar Lal Jat, J. Alyce Bradbury, Laura M. DeGraff, Kunjie Hua, Kenneth B. Tomer, John R. Falck, Darryl C. Zeldin, Craig R. Lee
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 2124-2136 (2014)
Adipogenesis plays a critical role in the initiation and progression of obesity. Although cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) have emerged as a potential therapeutic target for cardiometabolic disease, the functional contri
Externí odkaz:
https://doaj.org/article/b28891d15da546688f2635126a06d9ed