Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Matthew L Rook"'
Publikováno v:
eLife, Vol 9 (2020)
Acid-sensing ion channels (ASICs) are neuronal sodium-selective channels activated by reductions in extracellular pH. Structures of the three presumptive functional states, high-pH resting, low-pH desensitized, and toxin-stabilized open, have all bee
Externí odkaz:
https://doaj.org/article/2914653332f5469fa8a86b5e76b7d4de
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Structures of the trimeric acid-sensing ion channel have been solved in the resting, toxin-bound open and desensitized states. Within the extracellular domain, there is little difference between the toxin-bound open state and the desensitized state.
Externí odkaz:
https://doaj.org/article/6d8fd25387bc46e9a27a83f62a2a78f1
Publikováno v:
J Physiol
Acid-sensing ion channels (ASICs) are a class of trimeric cation-selective ion channels activated by changes in pH within the physiological range. They are widely expressed in the central and peripheral nervous systems where they participate in a ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd26cc2c771ec2f93b9c40696b63d780
https://doi.org/10.1113/jp278707
https://doi.org/10.1113/jp278707
Desensitization is a common feature of ligand-gated ion channels although the molecular cause varies widely between channel types. Mutations that substantially reduce or abolish desensitization have been described for many ligand-gated ion channels i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::624b0269a66f31c4d33a0100f9b9128e
https://doi.org/10.1101/2020.12.19.423606
https://doi.org/10.1101/2020.12.19.423606
Publikováno v:
Biophysical Journal. 121:15a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e9ced00c65abbbe3851f1afd4789091
https://doi.org/10.1016/j.bpj.2021.11.2638
https://doi.org/10.1016/j.bpj.2021.11.2638
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Acid-sensing ion channels (ASICs) are neuronal sodium-selective channels activated by reductions in extracellular pH. Structures of the three presumptive functional states, high-pH resting, low-pH desensitized, and toxin-stabilized open, have all bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6884da5c1ef8382ef3a232e1d5f55c
Publikováno v:
Biophysical Journal. 120:338a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::993fe581fa7213421a679f9b10366d80
https://doi.org/10.1016/j.bpj.2020.11.2114
https://doi.org/10.1016/j.bpj.2020.11.2114
Autor:
Matthew L. Rook, David M. MacLean, Kyle D. Berger, Paul J. Kammermeier, Tyler Couch, Tyler W McCullock, Dana L Kneisley
Publikováno v:
Biophysical Journal. 120:337a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89f3345eff322b8e1e3bf941b75a0e66
https://doi.org/10.1016/j.bpj.2020.11.2112
https://doi.org/10.1016/j.bpj.2020.11.2112
Autor:
David M. MacLean, Matthew L. Rook
Publikováno v:
Biophysical Journal. 118:583a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55baf3b957af4cd8efcee9eed16ee448
https://doi.org/10.1016/j.bpj.2019.11.3163
https://doi.org/10.1016/j.bpj.2019.11.3163