Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Matthew L Bendall"'
Autor:
Matthew L Bendall, Miguel de Mulder, Luis Pedro Iñiguez, Aarón Lecanda-Sánchez, Marcos Pérez-Losada, Mario A Ostrowski, R Brad Jones, Lubbertus C F Mulder, Gustavo Reyes-Terán, Keith A Crandall, Christopher E Ormsby, Douglas F Nixon
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1006453 (2019)
Characterization of Human Endogenous Retrovirus (HERV) expression within the transcriptomic landscape using RNA-seq is complicated by uncertainty in fragment assignment because of sequence similarity. We present Telescope, a computational software to
Externí odkaz:
https://doaj.org/article/8960a0b0df054048b5a274ad3c967189
Autor:
Rodrigo R. R. Duarte, Oliver Pain, Matthew L. Bendall, Miguel de Mulder Rougvie, Jez L. Marston, Sashika Selvackadunco, Claire Troakes, Szi Kay Leung, Rosemary A. Bamford, Jonathan Mill, Paul F. O’Reilly, Deepak P. Srivastava, Douglas F. Nixon, Timothy R. Powell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Human endogenous retroviruses (HERVs) are repetitive elements previously implicated in major psychiatric conditions, but their role in aetiology remains unclear. Here, we perform specialised transcriptome-wide association studies that consid
Externí odkaz:
https://doaj.org/article/b450345af2824456a3a8a93c234cbf75
Autor:
Marcos Pérez-Losada, Eduardo Castro-Nallar, Matthew L Bendall, Robert J Freishtat, Keith A Crandall
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131819 (2015)
High-throughput sequencing (HTS) analysis of microbial communities from the respiratory airways has heavily relied on the 16S rRNA gene. Given the intrinsic limitations of this approach, airway microbiome research has focused on assessing bacterial c
Externí odkaz:
https://doaj.org/article/819781b1328f4f63b19b5b3e0b5d863a
Autor:
Nicholas Dopkins, Bhavya Singh, Stephanie Michael, Panpan Zhang, Jez L. Marston, Tongyi Fei, Manvendra Singh, Cedric Feschotte, Nicholas Collins, Matthew L. Bendall, Douglas F. Nixon
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human genome. Our understanding of HERVs in physiology primarily surrounds their non-coding fu
Externí odkaz:
https://doaj.org/article/b795fcd1fa0147f6a7b6d5bddd81345f
Autor:
Nicholas Dopkins, Tongyi Fei, Stephanie Michael, Nicholas Liotta, Kejun Guo, Kaylee L. Mickens, Brad S. Barrett, Matthew L. Bendall, Stephanie M. Dillon, Cara C. Wilson, Mario L. Santiago, Douglas F. Nixon
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105133- (2024)
Summary: Background: Endogenous retroelements (EREs), including human endogenous retroviruses (HERVs) and long interspersed nuclear elements (LINEs), comprise almost half of the human genome. Our previous studies of the interferome in the gut suggest
Externí odkaz:
https://doaj.org/article/77bd4000351b463188eba2fb539d30cc
Autor:
Nicholas Dopkins, Bhavya Singh, Stephanie Michael, Morgan M. O’Mara, Jez L. Marston, Tongyi Fei, Matthew L. Bendall, Douglas F. Nixon
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Transposable elements (TEs) are mobile genomic sequences that encompass roughly 50% of the human genome. Class 1 TEs, or “retrotransposons,” mobilize through the production of an RNA intermediate that is then reverse transcribed to form
Externí odkaz:
https://doaj.org/article/2a8e87ef15604f50b84d1e0755b27d0d
Autor:
Maria Carolina Viana, Gislaine Curty, Carolina Furtado, Bhavya Singh, Matthew L. Bendall, João P. B. Viola, Andreia Cristina de Melo, Marcelo A. Soares, Miguel A. M. Moreira
Publikováno v:
Frontiers in Microbiology, Vol 13 (2023)
Due to immunosuppressive cancer therapies, cancer patients diagnosed with COVID-19 have a higher chance of developing severe symptoms and present a higher mortality rate in comparison to the general population. Here we show a comparative analysis of
Externí odkaz:
https://doaj.org/article/35ade85c1dd547fbb707629b7c95bc67
Autor:
Nicholas Dopkins, Morgan M. O’Mara, Elsa Lawrence, Tongyi Fei, Santiago Sandoval-Motta, Douglas F. Nixon, Matthew L. Bendall
Publikováno v:
Molecular Cell. 82:3763-3768
Germ cells are subject to exogenous retrovirus infections occasionally resulting in the genomic integration of retroviral gene sequences. These endogenized retroviruses (ERVs) are found throughout mammalian genomes. Initially thought to be inert, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8750b1c42a9b042b5d92d29b5ec595a
https://doi.org/10.1016/j.molcel.2022.09.011
https://doi.org/10.1016/j.molcel.2022.09.011
Autor:
Keith A. Crandall, Douglas F. Nixon, Katherine B. Chiappinelli, Matthew L. Bendall, Luis P. Iñiguez, Jez L. Marston, Margaret C. Steiner
Human endogenous retroviruses (HERV) have been implicated in a variety of diseases including cancers. Recent research implicates HERVs in epigenetic gene regulation. Here we utilize a recently developed bioinformatics tool for identifying HERV expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca1241bb471f5bd41dda5310901d0da
https://doi.org/10.1158/0008-5472.c.6513061.v1
https://doi.org/10.1158/0008-5472.c.6513061.v1
Publikováno v:
JCI Insight. 7
Uveal melanoma (UM) is a unique disease in that patients with primary UM are well stratified based on their risk of developing metastasis, yet there are limited effective treatments once metastases occur. There is an urgent need to better understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05251833498d737a92f6688184c60b1d
https://doi.org/10.1172/jci.insight.147172
https://doi.org/10.1172/jci.insight.147172