Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Matthew L, Maddess"'
Autor:
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
Publikováno v:
Journal of Medicinal Chemistry. 65:16801-16817
Autor:
David A. Candito, Theodore A. Martinot, Jing Su, Josep Saurí, Yu-hong Lam, Leo A. Joyce, Steven M. Silverman, David L. Sloman, Matthew L. Maddess, Michelle R. Machacek
Publikováno v:
Organic Process Research & Development. 26:3034-3041
Autor:
Ji Qi, Yu-hong Lam, Adrian Goodyear, Jie Wang, Ed Cleator, Mahbub Alam, Mariko Morimoto, Andy Kirtley, Andrew D. Gibb, Steven F. Oliver, Stephen P. Keen, Matthew L. Maddess, Lingzhu Kong, Alejandro Dieguez-Vazquez, Xin Wen
Publikováno v:
Organic Process Research & Development. 26:640-647
Autor:
Frederique M. Poulet, J. Michael Ellis, Matthew E. Kennedy, Carrie G. Markgraf, Lauren M Timmins, Dianne K. Bryce, Sabu Kuruvilla, Janice D Woodhouse, Matthew J. Fell, Karin M. Otte, Christopher Ware, Laxminarayan G Hegde, Matthew L. Maddess, Paul J Ciaccio
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 377:11-19
Gain-of-function mutations in leucine-rich kinase 2 (LRRK2) are associated with increased incidence of Parkinson disease (PD); thus, pharmacological inhibition of LRRK2 kinase activity is postulated as a disease-modifying treatment of PD. Histomorpho
Autor:
Derun Li, William P. Kaplan, Cayetana Zarate, Matthew L. Maddess, Kaitlyn Marie Logan, Hongming Li, Peter Fuller, Zhiguo Jake Song, Meng Chen, Michael J. Ardolino, Jing Su, Luis E. Torres, Gregori J. Morriello
Publikováno v:
Organic Process Research & Development. 25:642-647
The application of bicyclo[1.1.1]pentanes (BCPs) as phenyl bioisosteres has garnered significant attention, as these structural motifs can improve the physiochemical profiles of drug candidates. De...
Autor:
Chunhui Huang, Christian Fischer, Michelle R. Machacek, Stephane Bogen, Tesfaye Biftu, Xianhai Huang, Michael H. Reutershan, Ryan Otte, Qingmei Hong, Zhicai Wu, Yang Yu, Min Park, Lei Chen, Purakkattle Biju, Ian Knemeyer, Ping Lu, Christopher J. Kochansky, Michael Brendan Hicks, Yong Liu, Roy Helmy, Xavier Fradera, Anthony Donofrio, Josh Close, Matthew L. Maddess, Catherine White, David L. Sloman, Nunzio Sciammetta, Jun Lu, Craig Gibeau, Vladimir Simov, Hongjun Zhang, Peter Fuller, David Witter
Publikováno v:
ACS Med Chem Lett
[Image: see text] Mutant isocitrate dehydrogenase 1 (IDH1) has been identified as an attractive oncology target for which >70% of grade II and III gliomas and ∼10% of acute myeloid leukemia (AML) harbor somatic IDH1 mutations. These mutations confe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ecfd534a4182e5c705a82b16c3ffcc
https://europepmc.org/articles/PMC9014435/
https://europepmc.org/articles/PMC9014435/
Autor:
Wonsuk Chang, Michael D. Altman, Charles A. Lesburg, Samanthi A. Perera, Jennifer A. Piesvaux, Gottfried K. Schroeder, Daniel F. Wyss, Saso Cemerski, Yiping Chen, Edward DiNunzio, Andrew M. Haidle, Thu Ho, Ilona Kariv, Ian Knemeyer, Johnny E. Kopinja, Brian M. Lacey, Jason Laskey, Jongwon Lim, Brian J. Long, Yanhong Ma, Matthew L. Maddess, Bo-Sheng Pan, Jeremy P. Presland, Edward Spooner, Dietrich Steinhuebel, Quang Truong, Zhibo Zhang, Jianmin Fu, George H. Addona, Alan B. Northrup, Emma Parmee, James R. Tata, David Jonathan Bennett, Jared N. Cumming, Tony Siu, B. Wesley Trotter
Publikováno v:
Journal of medicinal chemistry. 65(7)
Stereochemically and structurally complex cyclic dinucleotide-based stimulator of interferon genes (STING) agonists were designed and synthesized to access a previously unexplored chemical space. The assessment of biochemical affinity and cellular po
Autor:
John A. McIntosh, Zhijian Liu, Brian M. Andresen, Nastaran Salehi Marzijarani, Jeffrey C. Moore, Nicholas M. Marshall, Margie Borra-Garske, Jennifer V. Obligacion, Patrick S. Fier, Feng Peng, Jacob H. Forstater, Matthew S. Winston, Chihui An, Wonsuk Chang, Jongwon Lim, Mark A. Huffman, Steven P. Miller, Fuh-Rong Tsay, Michael D. Altman, Charles A. Lesburg, Dietrich Steinhuebel, B. Wesley Trotter, Jared N. Cumming, Alan Northrup, Xiaodong Bu, Benjamin F. Mann, Mirlinda Biba, Kaori Hiraga, Grant S. Murphy, Joshua N. Kolev, Amanda Makarewicz, Weilan Pan, Iman Farasat, Rachel S. Bade, Kevin Stone, Da Duan, Oscar Alvizo, Donovan Adpressa, Erik Guetschow, Erik Hoyt, Erik L. Regalado, Steve Castro, Nelo Rivera, Joseph P. Smith, Fengqiang Wang, Alejandro Crespo, Deeptak Verma, Stephanus Axnanda, Zachary E. X. Dance, Paul N. Devine, David Tschaen, Keith A. Canada, Paul G. Bulger, Benjamin D. Sherry, Matthew D. Truppo, Rebecca T. Ruck, Louis-Charles Campeau, David Jonathan Bennett, Guy R. Humphrey, Kevin R. Campos, Matthew L. Maddess
Publikováno v:
Nature. 603(7901)
The introduction of molecular complexity in an atom- and step-efficient manner remains an outstanding goal in modern synthetic chemistry. Artificial biosynthetic pathways are uniquely able to address this challenge by using enzymes to carry out multi
Autor:
Josep Saurí, Michael J. Ardolino, Zhiguo J. Song, Lu Chen, Daniel J. Muzzio, Lushi Tan, Thomas Vickery, Jingjun Yin, Ji Qi, Chaomin Li, Yu-hong Lam, Ralph Zhao, Theodore A. Martinot, Matthew L. Maddess
Publikováno v:
Organic Process Research & Development. 23:1178-1190
The development of a stereospecific synthesis of a IDO1-selective inhibitor is described. The synthetic strategy toward enabling early discovery efforts along with additional findings pertaining to...
Autor:
Chaomin Li, Matthew L. Maddess
Publikováno v:
Organometallics. 38:81-84
A versatile synthesis of dihydropyridobenzodiazepines that proceeds via a palladium-catalyzed C–N coupling and catalytic hydrogenation cascade is reported. The intermediate 2-anilinonicotinaldehydes may be efficiently protected to ultimately afford