Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Matthew L, Bettini"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Conventional immunosuppressive functions of CD4+Foxp3+ regulatory T cells (Tregs) in type 1 diabetes (T1D) pathogenesis have been well described, but whether Tregs have additional non-immunological functions supporting tissue homeostasis in
Externí odkaz:
https://doaj.org/article/28158d6eaf4247f3b5b7e058103cd32c
Autor:
Hayley M. Reynolds, Matthew L. Bettini
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
As the prevalence of allergy and autoimmune disease in industrialized societies continues to rise, improving our understanding of the mechanistic roles behind microbiota-immune homeostasis has become critical for informing therapeutic interventions i
Externí odkaz:
https://doaj.org/article/cd51401b19d94878be4537376298649d
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Type-1 Diabetes (T1D) is a complex polygenic autoimmune disorder involving T-cell driven beta-cell destruction leading to hyperglycemia. There is no cure for T1D and patients rely on exogenous insulin administration for disease management. T1D is ass
Externí odkaz:
https://doaj.org/article/61d7e5ee3d41430387fab2a94d572ffa
Autor:
Andrew G. Ramstead, Jared A. Wallace, Soh-Hyun Lee, Kaylyn M. Bauer, William W. Tang, H. Atakan Ekiz, Thomas E. Lane, Ahmad A. Cluntun, Matthew L. Bettini, June L. Round, Jared Rutter, Ryan M. O’Connell
Publikováno v:
Cell Reports, Vol 30, Iss 9, Pp 2889-2899.e6 (2020)
Summary: Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvat
Externí odkaz:
https://doaj.org/article/85eca401df46476092567316c9937106
Autor:
Yong Lin, Jelena Perovanovic, Yuelin Kong, Botond Z. Igyarto, Sandra Zurawski, Dean Tantin, Gerard Zurawski, Maria Bettini, Matthew L. Bettini
Publikováno v:
Diabetes. 71:1735-1745
Thymic presentation of self-antigens is critical for establishing a functional yet self-tolerant T-cell population. Hybrid peptides formed through transpeptidation within pancreatic β-cell lysosomes have been proposed as a new class of autoantigens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d81436041a407da33f364527a2d091
https://doi.org/10.2337/db21-1069
https://doi.org/10.2337/db21-1069
Autor:
Dario A.A. Vignali, Charles G. Drake, Alan J. Korman, Drew M. Pardoll, Creg J. Workman, Paul J. Utz, Alcides Chaux, Matthew P. Smeltzer, George Netto, Joseph F. Grosso, Stephanie Tangsombatvisit, Chih Long Liu, Peter Vogel, David M. Gravano, Matthew L. Bettini, Christopher J. Nirschl, Mark Selby, Jaishree Bankoti, Monica V. Goldberg, Meghan E. Turnis, Seng-Ryong Woo
PDF file - 1.1MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800d65bdbf8961b28d0569bfc63fada4
https://doi.org/10.1158/0008-5472.22392654
https://doi.org/10.1158/0008-5472.22392654
Autor:
Matthew L. Bettini, Maria Bettini
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
The strongest susceptibility allele for Type 1 Diabetes (T1D) is human leukocyte antigen (HLA), which supports a central role for T cells as the drivers of autoimmunity. However, the precise mechanisms that allow thymic escape and peripheral activati
Externí odkaz:
https://doaj.org/article/c3e0bc0bffaa4402b29b98f222dc236e
Autor:
Matthew L. Bettini, Maria Bettini
Publikováno v:
Diabetes
Critical insights into the etiology of type 1 diabetes (T1D) came from genome-wide association studies that unequivocally connected genetic susceptibility to immune cell function. At the top of the susceptibility are genes involved in regulatory T-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f3d90fd990d109f4a9e200ad651ab2
https://doi.org/10.2337/dbi18-0058
https://doi.org/10.2337/dbi18-0058
Autor:
Matthew L. Bettini, Maria Bettini, Gerard Zurawski, Dean Tantin, Sandra Zurawski, Botond Z. Igyarto, Yuelin Kong, Jelena Perovanovic, Yong Lin
Thymic presentation of self-antigens is critical for establishing a functional yet self-tolerant T cell population. Hybrid peptides formed through transpeptidation within pancreatic beta cell lysosomes have been proposed as a new class of autoantigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c73e554984f6a0206e94f2d5989de59
https://doi.org/10.2337/figshare.19799728.v1
https://doi.org/10.2337/figshare.19799728.v1
Autor:
Yuelin Kong, Yi Jing, Denise Allard, Marissa A. Scavuzzo, Maran L. Sprouse, Malgorzata Borowiak, Matthew L. Bettini, Maria Bettini
Publikováno v:
Eur J Immunol
The contribution of low affinity T cells to autoimmunity in the context of polyclonal T cell responses is understudied due to the limitations in their capture by tetrameric reagents and low level of activation in response to antigenic stimulation. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984f0fa87c5d643b3af8b8a95a09983e
https://europepmc.org/articles/PMC9673076/
https://europepmc.org/articles/PMC9673076/