Výsledky vyhledávání - "Matthew K. Howe"

Akademický článek

Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase

Autor: Matthew K. Howe, Kennichi Dowdell, Amitava Roy, Julie E. Niemela, Wyndham Wilson, Joshua J. McElwee, Jason D. Hughes, Jeffrey I. Cohen

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Interleukin-2-inducible T cell kinase (ITK) is critical for T cell signaling and cytotoxicity, and control of Epstein-Barr virus (EBV). We identified a patient with a novel homozygous missense mutation (D540N) in a highly conserved residue in the kin

Externí odkaz: https://doaj.org/article/8d21737dd3e54543aa8b76ed89880070

Zobrazit plný text záznamu

Supplementary Figures 1-9 from CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells

Autor: Donald P. McDonnell, Anthony R. Means, Myles Brown, Qianben Wang, Ian Cushman, Abigail M. Brunner, Bryan M. Wittmann, Matthew K. Howe, Daniel E. Frigo

Supplementary Figures 1-9 from CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0a489320d3acbe0155adadc965264e
https://doi.org/10.1158/0008-5472.22388948

Zobrazit plný text záznamu

Supplementary Methods and Materials, Figure Legends 1-9, Table 1 from CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells

Autor: Donald P. McDonnell, Anthony R. Means, Myles Brown, Qianben Wang, Ian Cushman, Abigail M. Brunner, Bryan M. Wittmann, Matthew K. Howe, Daniel E. Frigo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bd0654ef34f291e117e9dec9c52898
https://doi.org/10.1158/0008-5472.22388945

Zobrazit plný text záznamu

Patients With Natural Killer (NK) Cell Chronic Active Epstein-Barr Virus Have Immature NK Cells and Hyperactivation of PI3K/Akt/mTOR and STAT1 Pathways

Autor: Doreen Garabedian, Kennichi C. Dowdell, Evan Shereck, Geoffrey T. Hart, Julie E. Niemela, Hye Sun Kuehn, Qingxue Li, Lesia K. Dropulic, Laura Schulz, Matthew K. Howe, Tatyana Feldman, Eric O. Long, Jennifer Stoddard, Gulbu Uzel, Jeffrey I. Cohen, Hua Su, Sergio D. Rosenzweig, Kelly Liepshutz, Amy P. Hsu

Publikováno v: J Infect Dis

Background Chronic active Epstein-Barr virus (CAEBV) presents with high levels of viral genomes in blood and tissue infiltration with Epstein-Barr virus (EBV)–positive lymphocytes. The pathogenesis of CAEBV is poorly understood. Methods We evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81721d69432ccf96fc716d2d1b7e3b2
https://pubmed.ncbi.nlm.nih.gov/32386415

Zobrazit plný text záznamu

Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase

Autor: A. Roy, Kennichi C. Dowdell, Matthew K. Howe, Jeffrey I. Cohen, Joshua McElwee, Julie E. Niemela, Wyndham H. Wilson, Jason D. Hughes

Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bef1c1f9e33163de5e94e150094506
https://doi.org/10.3389/fimmu.2019.02000

Zobrazit plný text záznamu

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

Autor: Ruchita V. Pillai, Michihisa Umetani, Suzanne E. Wardell, Joseph Geradts, Sunil Suchindran, Erik R. Nelson, Sunghee Park, Varun Sondhi, Matthew K. Howe, Nicole J. Carver, Patrick Sullivan, J. Jasper, Donald P. McDonnell

Publikováno v: Science. 342:1094-1098

Cholesterol and Cancer Obesity and high cholesterol levels are associated with an increased risk of breast cancer in post-menopausal women. Nelson et al. (p. 1094 ) found that a specific metabolite of cholesterol, 27-hydroxycholesterol (27HC), promot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04299698958f7208350dffddbb3d55b5
https://doi.org/10.1126/science.1241908

Zobrazit plný text záznamu

An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target

Autor: Timothy A.J. Haystead, Matthew K. Howe, Brittany L. Speer, David R. Loiselle, Philip F. Hughes, Subhash G. Vasudevan

Publikováno v: Antiviral research. 130

An estimated three billion people are at risk of Dengue virus (DENV) infection worldwide and there are currently no approved therapeutic interventions for DENV infection. Due to the relatively small size of the DENV genome, DENV is reliant on host fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40df7db2c5dbfb2c8d8efbd25f3285ff
https://pubmed.ncbi.nlm.nih.gov/27058774

Zobrazit plný text záznamu

The Oxysterol, 27-Hydroxycholesterol, Links Cholesterol Metabolism to Bone Homeostasis Through Its Actions on the Estrogen and Liver X Receptors

Autor: Michihisa Umetani, Ryan D. Michalek, Jeffrey C. Rathmell, Erik R. Nelson, Diane Gesty-Palmer, Xiaojuan Wang, Matthew K. Howe, Glenda L. Evans, Sundeep Khosla, Donald P. McDonnell, Carolyn D. DuSell

Publikováno v: Endocrinology. 152:4691-4705

Osteoporosis and age-related bone loss are important public health concerns. Therefore, there is a high level of interest in the development of medical interventions and lifestyle changes that reduce the incidence of osteoporosis and age-related bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0307ed95336bf03d7eb77047ef375be
https://doi.org/10.1210/en.2011-1298

Zobrazit plný text záznamu

New Indications for HSP90 and HSP70 Inhibitors as Antiviral Drugs

Autor: Timothy A.J. Haystead, Matthew K. Howe

Publikováno v: Heat Shock Proteins ISBN: 9783319172101

Viruses infect host cells and elicit a broad range of ailments. The viral genome is relatively small and therefore viruses are reliant on host factors throughout the viral lifecycle. The molecular chaperones, heat shock proteins 70 (HSP70) and 90 (HS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8add3c22fbd0d16b4efdb8ffcc38b605
https://doi.org/10.1007/978-3-319-17211-8_10

Zobrazit plný text záznamu

Androgens promote prostate cancer cell growth through induction of autophagy

Autor: Jenny J. Han, Donald P. McDonnell, Alan R. Burns, Yan Shi, Matthew K. Howe, Fabiola F. Mehta, Jayantha B. Tennakoon, Daniel E. Frigo, Fatima A. Merchant

Publikováno v: Molecular endocrinology (Baltimore, Md.). 27(2)

Androgens regulate both the physiological development of the prostate and the pathology of prostatic diseases. However, the mechanisms by which androgens exert their regulatory activities on these processes are poorly understood. In this study, we ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfc6049e73fe2422c9517582480806a
https://pubmed.ncbi.nlm.nih.gov/23250485

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání