Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger

Autor: Matthew K. Brittain, Tatiana Brustovetsky, Patrick L. Sheets, Joel M. Brittain, Rajesh Khanna, Theodore R. Cummins, Nickolay Brustovetsky

Publikováno v: Neurobiology of Disease, Vol 46, Iss 1, Pp 109-117 (2012)

Glutamate-induced delayed calcium dysregulation (DCD) is a causal factor leading to neuronal death. The mechanism of DCD is not clear but Ca2+ influx via N-methyl-d-aspartate receptors (NMDAR) and/or the reverse plasmalemmal Na+/Ca2+ exchanger (NCXre

Externí odkaz: https://doaj.org/article/40f52cabedd64efea02ac8bd6475fef2

High performance liquid chromatography tandem mass spectrometry assay for the determination of cobinamide in pig plasma

Autor: Matthew K. Brittain, Brent A. McCracken

Publikováno v: Journal of Chromatography B. 1006:104-111

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been widely utilized for the analysis of compounds in biological matrices due to its selectivity and sensitivity. This study describes the application of an LC-MS/MS-based approach toward

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6338368f20cab4d4b3df6591a11329d7
https://doi.org/10.1016/j.jchromb.2015.10.008

Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection

Autor: Tanya Burney, Michael C. Babin, Sari B. Mahon, Vikhyat S. Bebarta, Renate B. Pilz, David Mukai, Matthew Brenner, David Yoon, Gerry R. Boss, Matthew K. Brittain, Norma Garrett, Adriano Chan

Publikováno v: Bebarta, VS; Brittain, M; Chan, A; Garrett, N; Yoon, D; Burney, T; et al.(2017). Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection. ANNALS OF EMERGENCY MEDICINE, 69(6), 718-725. doi: 10.1016/j.annemergmed.2016.09.034. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5n44t6fs

The 2 antidotes for acute cyanide poisoning in the United States must be administered by intravenous injection. In the out-of-hospital setting, intravenous injection is not practical, particularly for mass casualties, and intramuscular injection woul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165833c23dd56dfe6c40c801d924c667
https://pubmed.ncbi.nlm.nih.gov/28041825

KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I

Autor: Pinelis Vg, Patrick L. Sheets, Nickolay Brustovetsky, Tatiana Brustovetsky, Matthew K. Brittain, Theodore R. Cummins

Publikováno v: British Journal of Pharmacology. 162:255-270

BACKGROUND AND PURPOSE An isothiourea derivative (2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methane sulfonate (KB-R7943), a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev), was instrumental in establishing the role of NCXrev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1f91bfc44ca07e4b0e3b2934d8facbc
https://doi.org/10.1111/j.1476-5381.2010.01054.x

Evaluation of HemogloBind™ treatment for preparation of samples for cholinesterase analysis

Autor: Kevin G, McGarry, Ryan A, Bartlett, Nicholas J, Machesky, Thomas H, Snider, Robert A, Moyer, David T, Yeung, Matthew K, Brittain

Publikováno v: Advances in bioscience and biotechnology

Acetylcholine is an essential neurotransmitter found throughout the nervous system. Its action on postsynaptic receptors is regulated through hydrolysis by various carboxylesterases, especially cholinesterases (ChEs). The acute toxicity of organophos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53defb062613f8b34d75521d33124b00
https://pubmed.ncbi.nlm.nih.gov/24749000