Zobrazeno 1 - 10
of 371
pro vyhledávání: '"Matthew K Waldor"'
Publikováno v:
eLife, Vol 12 (2023)
Diverse chemical modifications fine-tune the function and metabolism of tRNA. Although tRNA modification is universal in all kingdoms of life, profiles of modifications, their functions, and physiological roles have not been elucidated in most organi
Externí odkaz:
https://doaj.org/article/e50930f8914840a9ba9313a5d961f35a
Autor:
Karthik Hullahalli, Matthew K Waldor
Publikováno v:
eLife, Vol 10 (2021)
The dissemination of pathogens through blood and their establishment within organs lead to severe clinical outcomes. However, the within-host dynamics that underlie pathogen spread to and clearance from systemic organs remain largely uncharacterized.
Externí odkaz:
https://doaj.org/article/b988598bf6724dc5a1987d091a56fbe5
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009290 (2021)
Enterohemorrhagic Escherichia coli (EHEC) is a food-borne pathogen that causes diarrheal disease and the potentially lethal hemolytic uremic syndrome. We used an infant rabbit model of EHEC infection that recapitulates many aspects of human intestina
Externí odkaz:
https://doaj.org/article/5be0eabf74784161b23a97996f802f69
Autor:
Teresa del Peso Santos, Laura Alvarez, Brandon Sit, Oihane Irazoki, Jonathon Blake, Benjamin R Warner, Alyson R Warr, Anju Bala, Vladimir Benes, Matthew K Waldor, Kurt Fredrick, Felipe Cava
Publikováno v:
eLife, Vol 10 (2021)
Adaptation to shifting temperatures is crucial for the survival of the bacterial pathogen Vibrio cholerae. Here, we show that colony rugosity, a biofilm-associated phenotype, is regulated by temperature in V. cholerae strains that naturally lack the
Externí odkaz:
https://doaj.org/article/e5723fd7fcbd4bdf8fd510558c6ce998
Autor:
Alyson R Warr, Troy P Hubbard, Diana Munera, Carlos J Blondel, Pia Abel Zur Wiesch, Sören Abel, Xiaoxue Wang, Brigid M Davis, Matthew K Waldor
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007652 (2019)
Enterohemorrhagic Escherichia coli O157:H7 (EHEC) is an important food-borne pathogen that colonizes the colon. Transposon-insertion sequencing (TIS) was used to identify genes required for EHEC and E. coli K-12 growth in vitro and for EHEC growth in
Externí odkaz:
https://doaj.org/article/fc771d6512744e9a861868904cbe23c8
Autor:
Zhe Ma, Jie Peng, Dandan Yu, Joseph S Park, Huixing Lin, Bin Xu, Chengping Lu, Hongjie Fan, Matthew K Waldor
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007737 (2019)
Streptococcus equi subsp. zooepidemicus (SEZ) is a zoonotic pathogen capable of causing meningitis in humans. The mechanisms that enable pathogens to traverse the blood-brain barrier (BBB) are incompletely understood. Here, we investigated the role o
Externí odkaz:
https://doaj.org/article/7f450e86330e4839abde4f5c6bf3cb14
Autor:
Brandon Sit, Ting Zhang, Bolutife Fakoya, Aklima Akter, Rajib Biswas, Edward T Ryan, Matthew K Waldor
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007417 (2019)
Oral cholera vaccines (OCVs) are being increasingly employed, but current killed formulations generally require multiple doses and lack efficacy in young children. We recently developed a new live-attenuated OCV candidate (HaitiV) derived from a Vibr
Externí odkaz:
https://doaj.org/article/e9ffc8d26be744d3aa6564a3a2a5b4a9
Autor:
Kaiyu Yin, Yunpeng Guan, Ruiqing Ma, Lifan Wei, Bing Liu, Xiaohong Liu, Xiangshan Zhou, Yue Ma, Yuanxing Zhang, Matthew K Waldor, Qiyao Wang
Publikováno v:
PLoS Pathogens, Vol 14, Iss 8, p e1007272 (2018)
Edwardsiella piscicida is a leading fish pathogen that causes significant economic loses in the aquaculture industry. The pathogen depends on type III and type VI secretion systems (T3/T6SS) for growth and virulence in fish and the expression of both
Externí odkaz:
https://doaj.org/article/3e7f6c2490294fda920b0f07f5f566a2
Autor:
Alejandra Alvarado, Andreas Kjær, Wen Yang, Petra Mann, Ariane Briegel, Matthew K Waldor, Simon Ringgaard
Publikováno v:
eLife, Vol 6 (2017)
Chemotaxis proteins organize into large, highly ordered, chemotactic signaling arrays, which in Vibrio species are found at the cell pole. Proper localization of signaling arrays is mediated by ParP, which tethers arrays to a cell pole anchor, ParC.
Externí odkaz:
https://doaj.org/article/7e9aae051f4d44fa926d8737f70020ff
Autor:
Michael C Chao, Shijia Zhu, Satoshi Kimura, Brigid M Davis, Eric E Schadt, Gang Fang, Matthew K Waldor
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005739 (2015)
[This corrects the article DOI: 10.1371/journal.pgen.1005666.].
Externí odkaz:
https://doaj.org/article/cf01c02005bf4b14924c38768632f519