Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase.

Autor: Nicola N Lynskey, Mark Reglinski, Damien Calay, Matthew K Siggins, Justin C Mason, Marina Botto, Shiranee Sriskandan

Publikováno v: PLoS Pathogens, Vol 13, Iss 8, p e1006493 (2017)

The complement cascade is crucial for clearance and control of invading pathogens, and as such is a key target for pathogen mediated host modulation. C3 is the central molecule of the complement cascade, and plays a vital role in opsonization of bact

Externí odkaz: https://doaj.org/article/7031e2a0cadc406fa19911befda17da0

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Autor: Felicity Liew, Shubha Talwar, Andy Cross, Brian J. Willett, Sam Scott, Nicola Logan, Matthew K. Siggins, Dawid Swieboda, Jasmin K. Sidhu, Claudia Efstathiou, Shona C. Moore, Chris Davis, Noura Mohamed, Jose Nunag, Clara King, A.A. Roger Thompson, Sarah L. Rowland-Jones, Annemarie B. Docherty, James D. Chalmers, Ling-Pei Ho, Alexander Horsley, Betty Raman, Krisnah Poinasamy, Michael Marks, Onn Min Kon, Luke Howard, Daniel G. Wootton, Susanna Dunachie, Jennifer K. Quint, Rachael A. Evans, Louise V. Wain, Sara Fontanella, Thushan I. de Silva, Antonia Ho, Ewen Harrison, J. Kenneth Baillie, Malcolm G. Semple, Christopher Brightling, Ryan S. Thwaites, Lance Turtle, Peter J.M. Openshaw, Beatrice Alex, Petros Andrikopoulos, Benjamin Bach, Wendy S. Barclay, Debby Bogaert, Meera Chand, Kanta Chechi, Graham S. Cooke, Ana da Silva Filipe, Thushan de Silva, Gonçalo dos Santos Correia, Marc-Emmanuel Dumas, Jake Dunning, Tom Fletcher, Christopher A. Green, William Greenhalf, Julian Griffin, Rishi K. Gupta, Ewen M. Harrison, Antonia Y.W. Ho, Karl Holden, Peter W. Horby, Samreen Ijaz, Say Khoo, Paul Klenerman, Andrew Law, Matthew Lewis, Sonia Liggi, Wei Shen Lim, Lynn Maslen, Alexander J. Mentzer, Laura Merson, Alison M Meynert, Mahdad Noursadeghi, Michael Olanipekun, Anthonia Osagie, Massimo Palmarini, Carlo Palmieri, William A. Paxton, Georgios Pollakis, Nicholas Price, Andrew Rambaut, David L Robertson, Clark D. Russell, Vanessa Sancho-Shimizu, Caroline Sands, Janet T. Scott, Louise Sigfrid, Tom Solomon, Shiranee Sriskandan, David Stuart, Charlotte Summers, Olivia V. Swann, Zoltan Takats, Panteleimon Takis, Richard S. Tedder, Emma C. Thomson, Lance C.W. Turtle, Maria Zambon, Thomas M. Drake, Cameron J. Fairfield, Stephen R. Knight, Kenneth A. Mclean, Derek Murphy, Lisa Norman, Riinu Pius, Catherine A. 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Publikováno v: 2022, ' SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination ', EBioMedicine, pp. 104402 . https://doi.org/10.1016/j.ebiom.2022.104402
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Data sharing statement This is an Open Access article under the CC BY 4.0 license The ISARIC4C protocol, data sharing and publication policy are available at https://isaric4c.net. ISARIC4C's Independent Data and Material Access Committee welcomes app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0592a647b5a64e93f00ff7a4d587107e
https://hdl.handle.net/20.500.11820/950f81a2-96ec-44d3-8359-457091daf1b7

Frequency of transmission, asymptomatic shedding, and airborne spread of Streptococcus pyogenes in schoolchildren exposed to scarlet fever: a prospective, longitudinal, multicohort, molecular epidemiological, contact-tracing study in England, UK

Autor: Rebecca Cordery, Amrit K Purba, Lipi Begum, Ewurabena Mills, Mia Mosavie, Ana Vieira, Elita Jauneikaite, Rhoda C Y Leung, Matthew K Siggins, Derren Ready, Peter Hoffman, Theresa Lamagni, Shiranee Sriskandan

Publikováno v: e375
e366

Background:\ud Despite recommendations regarding prompt treatment of cases and enhanced hygiene measures, scarlet fever outbreaks increased in England between 2014 and 2018. We aimed to assess the effects of standard interventions on transmission of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc118ea11fc92b70b0bb8109a35eef2
https://pubmed.ncbi.nlm.nih.gov/35544097

PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury

Autor: Matthew K. Siggins, Wafa Khamri, Thomas O’Connor, Evangelos Triantafyllou, Mark Thursz, Marie-Anne Mawhin, Mark J. W. McPhail, Hannah C. Husbyn, Kevin J. Woollard, Sujit Mukherjee, Marina Botto, Cathrin Gudd, Robert D. Goldin, Christine Bernsmeier, Charalambos G. Antoniades, Lucia A. Possamai, Francesca M. Trovato, Julia Wendon, Hiromi Kudo

Publikováno v: The Journal of Clinical Investigation

Patients with acute liver failure (ALF) have systemic innate immune suppression and increased susceptibility to infections. Programmed cell death 1 (PD-1) expression by macrophages has been associated with immune suppression during sepsis and cancer.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57ff30014337155b03c74b6c2ac765a
https://doi.org/10.1172/jci140196

Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection

Autor: Claire E. Turner, David A. Jackson, Kristin Krohn Huse, Shiranee Sriskandan, Kevin J. Woollard, Max Pearson, Nicola N. Lynskey, Louise A. Johnson, Matthew K. Siggins, Suneale Banerji, Lucy Lamb

Publikováno v: Siggins, M K, Lynskey, N N, Lamb, L E, Johnson, L A, Huse, K K, Pearson, M, Banerji, S, Turner, C E, Woollard, K, Jackson, D G & Sriskandan, S 2020, ' Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection ', Nature Communications, vol. 11, no. 1, 4697, pp. 1-12 . https://doi.org/10.1038/s41467-020-18454-0
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus far ascribed only to cancer cells. Here, we report that Streptococcus pyogenes also hijack lymphatic vessels to escape a local infection site, transiting through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d262d1d3331984d733f0cf6f468907d2
https://www.pure.ed.ac.uk/ws/files/165572170/s41467_020_18454_0.pdf