Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Matthew John Valli"'
Autor:
Reinhard Matthew Robert, James A. Monn, Bryan G. Johnson, Xushan Wang, Matthew John Valli, Beverly A. Heinz, Mark G. Bures, Steven S. Henry, Brian G. Getman, Joan H. Carter, John T. Catlow, Junliang Hao, David L. McKinzie, Steven Marc Massey, Marc Herin, Steven Swanson, Gregory A. Stephenson
Publikováno v:
Journal of Medicinal Chemistry. 56:4442-4455
As part of our ongoing interest in identifying novel agonists acting at metabotropic glutamate (mGlu) 2/3 receptors, we have explored the effect of structural modifications of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740), a po
Autor:
Sherri L. Andis, Steven S. Henry, Darryle D. Schoepp, Deborah D. Giera, Rebecca A. Wright, and Ann E. Kingston, Marc Herin, Gregory A. Stephenson, Bryan G. Johnson, Steven Marc Massey, John T. Catlow, Mark G. Bures, Matthew John Valli, James A. Monn
Publikováno v:
Journal of Medicinal Chemistry. 50:233-240
(-)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate (LY389795, (-)-3) is a highly potent and selective agonist of metabotropic glutamate receptors 2 (mGlu2) and 3 (mGlu3). As part of our ongoing research program, we have prepared S-oxidized var
Autor:
William J. Wheeler, Douglas D. O'Bannon, Tharp-Taylor Roger William, Joseph H. Kennedy, James A. Monn, Fengjiun Kuo, Matthew John Valli
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 48:605-620
As part of a program aimed at the design of conformationally constrained analogs of glutamic acid, (+)-2-aminobicyclo[3.1.0]hexane-2,6-carboxylic acid (1), identified as a highly potent, selective, group II metabotropic glutamate receptor agonist has
Autor:
Marvin M. Hansen, Harkness Allen Robert, James A. Monn, Richard A. Lewis, Kress Thomas Joseph, James P. Wepsiec, Matthew John Valli, Darryle D. Schoepp, Joseph P. Tizzano, Ann E. Kingston, Rebecca A. Wright, John L. Grutsch, Kelly R. Griffey, Sherri L. Andis, Bryan G. Johnson, Rosemarie Tomlinson, Steven Marc Massey
Publikováno v:
Journal of Medicinal Chemistry. 42:1027-1040
As part of our ongoing research program aimed at the identification of highly potent, selective, and systemically active agonists for group II metabotropic glutamate (mGlu) receptors, we have prepared novel heterobicyclic amino acids (-)-2-oxa-4-amin
Autor:
Joseph P. Tizzano, Trevor J. Howe, Steven March Massey, James A. Monn, Roger L. Robey, Bryan G. Johnson, Rebecca A. Wright, Darryle D. Schoepp, Craig R. Salhoff, Kelly R. Griffey, Charles A. Alt, David R. Helton, Rhodes Gary Anthony, Matthew John Valli, Mary Jeanne Kallman
Publikováno v:
Journal of Medicinal Chemistry. 40:528-537
2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (9) was designed as a conformationally constrained analog of glutamic acid. For 9, the key torsion angles (tau 1 and tau 2) which determine the relative positions of the alpha-amino acid and distal ca
Autor:
Darryle D. Schoepp, Joseph P. Tizzano, Trevor J. Howe, Jonathan W. Paschal, James A. Monn, David Lodge, Rebecca A. Wright, Jack B. Campbell, Ann Bond, Bryan G. Johnson, Craig R. Salhoff, Larry A. Spangle, Matthew John Valli, Kelly I. Griffey
Publikováno v:
Journal of Medicinal Chemistry. 39:2990-3000
The four isomers of 4-aminopyrrolidine-2,4-dicarboxylate (APDC) were prepared and evaluated for their effects at glutamate receptors in vitro. (2R,4R)-APDC (2a), an aza analog of the nonselective mGluR agonist (1S,3R)-1-aminocyclopentane-1,3-dicarbox
Autor:
David Lodge, Matthew John Valli, D D Schoepp, J. David Leander, James A. Monn, Rebecca A. True
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:95-98
LY300020, a conformationally constrained, ω-tetrazole-containing analog of L-glutamic acid was prepared and has been shown to be a relatively potent, highly selective, systemically- active AMPA receptor agonist. The activity of LY300020 was shown to
Autor:
James A. Monn, Matthew John Valli
Publikováno v:
ChemInform. 25
Racemic α-kainic acid (1) has been prepared from (1SR,2SR,5RS)-ethyl (N-(benzyloxycarbonyl)-3-aza-6-oxobicyclo[3.3.0]octane-2-carboxylate (11) in ca. 16% overall yield via a concise six-step synthetic sequence. Compound (11) is prepared on a large s
Autor:
James A. Monn, Charles A. Alt, Rhodes Gary Anthony, Kelly R. Griffey, Bryan G. Johnson, Mary Jeanne Kallman, Roger L. Robey, Darryle D. Schoepp, Craig R. Salhoff, Joseph P. Tizzano, Trevor J. Howe, David R. Helton, Steven March Massey, Rebecca A. Wright, Matthew John Valli
Publikováno v:
ChemInform. 28
2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (9) was designed as a conformationally constrained analog of glutamic acid. For 9, the key torsion angles (τ1 and τ2) which determine the relative positions of the α-amino acid and distal carboxyl
Autor:
Matthew John Valli, Rosemary Tomlinson, D D Schoepp, A.E. Kingston, Rebecca A. Wright, James A. Monn, Bryan G. Johnson
Publikováno v:
ChemInform. 29