Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Matthew Jefferson"'
Publikováno v:
JID Innovations, Vol 4, Iss 4, Pp 100283- (2024)
The skin is a multifunctional organ, forming a barrier between the external and internal environment, thereby functioning as a safeguard against extrinsic factors. Autophagy has been implicated in epidermal differentiation and in preserving skin home
Externí odkaz:
https://doaj.org/article/782a162258df4f87b4a950cf06656402
Autor:
Jamie A. Moore, Jayna J. Mistry, Charlotte Hellmich, Rebecca H. Horton, Edyta E. Wojtowicz, Aisha Jibril, Matthew Jefferson, Thomas Wileman, Naiara Beraza, Kristian M. Bowles, Stuart A. Rushworth
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
The bone marrow (BM) microenvironment regulates acute myeloid leukemia (AML) initiation, proliferation, and chemotherapy resistance. Following cancer cell death, a growing body of evidence suggests an important role for remaining apoptotic debris in
Externí odkaz:
https://doaj.org/article/2ddef2c9eaa54cbfb3cdecb6f86b7ee9
Autor:
Emily J. Jones, Zoe J. Matthews, Lejla Gul, Padhmanand Sudhakar, Agatha Treveil, Devina Divekar, Jasmine Buck, Tomasz Wrzesinski, Matthew Jefferson, Stuart D. Armstrong, Lindsay J. Hall, Alastair J. M. Watson, Simon R. Carding, Wilfried Haerty, Federica Di Palma, Ulrike Mayer, Penny P. Powell, Isabelle Hautefort, Tom Wileman, Tamas Korcsmaros
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 3 (2019)
Paneth cells are key epithelial cells that provide an antimicrobial barrier and maintain integrity of the small-intestinal stem cell niche. Paneth cell abnormalities are unfortunately detrimental to gut health and are often associated with digestive
Externí odkaz:
https://doaj.org/article/a6552716ae754941bec316fd4f082a50
Publikováno v:
Viruses, Vol 12, Iss 1, p 39 (2019)
Sindbis virus (SINV) infection induces eIF2α phosphorylation, which leads to stress granule (SG) assembly. SINV infection also stimulates autophagy, which has an important role in controlling the innate immune response. The importance of autophagy t
Externí odkaz:
https://doaj.org/article/4c3bc4044fe04ea0a4c6f07698912522
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88838 (2014)
The N-terminal protease of pestiviruses, N(pro) is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of int
Externí odkaz:
https://doaj.org/article/d729ccc1727849b0a71b533b3197dc9c
Autor:
Yingxue Wang, Maria Ramos, Matthew Jefferson, Weijiao Zhang, Naiara Beraza, Simon Carding, Penny P. Powell, James P. Stewart, Ulrike Mayer, Thomas Wileman
Publikováno v:
Science Advances. 8
The delivery of pathogens to lysosomes for degradation provides an important defense against infection. Degradation is enhanced when LC3 is conjugated to endosomes and phagosomes containing pathogens to facilitate fusion with lysosomes. In phagocytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be24ed236914c9dbc77056de3b3b052
https://doi.org/10.1126/sciadv.abn3298
https://doi.org/10.1126/sciadv.abn3298
Autor:
Deborah, Gelinas, Sara, Parvin-Nejad, Glenn, Phillips, Caroline, Cole, Tom, Hughes, Nicholas, Silvestri, Raghav, Govindarajan, Matthew, Jefferson, Joanna, Campbell, Heather, Burnett
Publikováno v:
Journal of the Neurological Sciences. 437:120268
While the clinical manifestations of myasthenia gravis (MG) are well understood, its humanistic impact is not. The objective of this systematic literature review (SLR) was to provide a comprehensive understanding of the humanistic burden of MG with r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd808ce3113e6b49e11186c9d203ef0
https://doi.org/10.1016/j.jns.2022.120268
https://doi.org/10.1016/j.jns.2022.120268
Autor:
James P. Stewart, Ben Bone, Ulrike Mayer, Ralph A. Tripp, Weijiao Zhang, Alex Zhekova, Penny P. Powell, Thomas Wileman, David Bitto, Parul Sharma, Angela L. Man, Yongping Bao, Simon R. Carding, Timothy Pearson, Yingxue Wang, Anja Kipar, Matthew Jefferson, Janine L. Coombes, Yohei Yamauchi
Publikováno v:
The EMBO Journal, 40 (6)
The EMBO Journal
The EMBO Journal
Influenza A virus (IAV) and SARS-CoV-2 (COVID-19) cause pandemic infections where cytokine storm syndrome and lung inflammation lead to high mortality. Given the high social and economic cost of respiratory viruses, there is an urgent need to underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aaaab61b181781c93f03e5a7d75306f
https://hdl.handle.net/20.500.11850/588888
https://hdl.handle.net/20.500.11850/588888
Autor:
Timothy Pearson, Thomas Wileman, Yongping Bao, Simon R. Carding, Ben Bone, Janine L. Coombes, Yingxue Wang, Anja Kipar, Angela L. Man, Matthew Jefferson, Yohei Yamauchi, Weijiao Zhang, Penny P. Powell, Ulrike Mayer, James P. Stewart, Parul Sharma, Ralph A. Tripp, Alex Zhekova
SummaryRespiratory viruses such as influenza A virus (IAV) and SARS-CoV-2 (Covid-19) cause pandemic infections where cytokine storm syndrome, lung inflammation and pneumonia lead to high mortality. Given the high social and economic cost of these vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84bf7e93794ce28c9aae62405f20fccb
https://doi.org/10.1101/2020.01.15.907873
https://doi.org/10.1101/2020.01.15.907873
Autor:
Thomas Wileman, Maryam Arasteh, Weijiao Zhang, Yingxue Wang, Shashank Rai, Naiara Beraza, Penny P. Powell, Ulrike Mayer, Devina Divekar, Timothy Pearson, Oliver Florey, Ronald Naumann, Simon R. Carding, Matthew Jefferson, Bertalan Bicsak
Publikováno v:
Autophagy
Macroautophagy/autophagy delivers damaged proteins and organelles to lysosomes for degradation, and plays important roles in maintaining tissue homeostasis by reducing tissue damage. The translocation of LC3 to the limiting membrane of the phagophore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a3ff007c852657fe9a646a1ebc052e
http://europepmc.org/articles/PMC6526875
http://europepmc.org/articles/PMC6526875