Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Matthew J. Yousefzadeh"'
Autor:
Lei Zhang, Louise E. Pitcher, Matthew J. Yousefzadeh, Laura J. Niedernhofer, Paul D. Robbins, Yi Zhu
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can develop a characteristic pathogenic senescence-associated secretory phenotype (SASP) that driv
Externí odkaz:
https://doaj.org/article/85d40b74e6c34ce2a01a1f9d5815c6bd
Autor:
Peter Gullickson, Yunwen W. Xu, Laura J. Niedernhofer, Elizabeth L. Thompson, Matthew J. Yousefzadeh
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
An effective humoral immune response necessitates the generation of diverse and high-affinity antibodies to neutralize pathogens and their products. To generate this assorted immune repertoire, DNA damage is introduced at specific regions of the geno
Externí odkaz:
https://doaj.org/article/037833a70a0f4955af8282ce0ecfe436
Autor:
Juan Antonio García-Carmona, Matthew J. Yousefzadeh, Fernando Alarcón-Soldevilla, Eva Fages-Caravaca, Tra L. Kieu, Mariah A. Witt, Ángel López-Ávila, Laura J. Niedernhofer, José Antonio Pérez-Vicente
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
We aimed to determine if an adolescent patient presenting with neurological impairment has xeroderma pigmentosum (XP). For this purpose, whole-exome sequencing was performed to assess mutations in XP genes. Dermal fibroblasts were established from a
Externí odkaz:
https://doaj.org/article/f121378d117e43b6b460fd98cf5559d3
Autor:
Jennifer Friedman, Lynne M. Bird, Richard Haas, Shira L. Robbins, Shareef A. Nahas, David P. Dimmock, Matthew J. Yousefzadeh, Mariah A. Witt, Laura J. Niedernhofer, Shimul Chowdhury
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 7, Pp n/a-n/a (2021)
ABSTRACT Background Cockayne syndrome (CS) is a rare autosomal recessive disorder characterized by growth failure and multisystemic degeneration. Excision repair cross‐complementation group 6 (ERCC6 OMIM: *609413) is the gene most frequently mutate
Externí odkaz:
https://doaj.org/article/8adc526922e441619f5e782f3745aa77
Autor:
Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I. Melos, Tamar Pirtskhalava, Christina L. Inman, Collin McGuckian, Erin A. Wade, Jonathon I. Kato, Diego Grassi, Mark Wentworth, Christin E. Burd, Edgar A. Arriaga, Warren L. Ladiges, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Laura J. Niedernhofer
Publikováno v:
EBioMedicine, Vol 36, Iss , Pp 18-28 (2018)
Background: Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmac
Externí odkaz:
https://doaj.org/article/02bd6a51774a495f90e8c345736d54df
Autor:
Andria R. Robinson, Matthew J. Yousefzadeh, Tania A. Rozgaja, Jin Wang, Xuesen Li, Jeremy S. Tilstra, Chelsea H. Feldman, Siobhán Q. Gregg, Caroline H. Johnson, Erin M. Skoda, Marie-Céline Frantz, Harris Bell-Temin, Hannah Pope-Varsalona, Aditi U. Gurkar, Luigi A. Nasto, Renã A.S. Robinson, Heike Fuhrmann-Stroissnigg, Jolanta Czerwinska, Sara J. McGowan, Nadiezhda Cantu-Medellin, Jamie B. Harris, Salony Maniar, Mark A. Ross, Christy E. Trussoni, Nicholas F. LaRusso, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Barbara Tudek, Nam V. Vo, Lora H. Rigatti, Patricia L. Opresko, Donna B. Stolz, Simon C. Watkins, Christin E. Burd, Claudette M. St. Croix, Gary Siuzdak, Nathan A. Yates, Paul D. Robbins, Yinsheng Wang, Peter Wipf, Eric E. Kelley, Laura J. Niedernhofer
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 259-273 (2018)
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate se
Externí odkaz:
https://doaj.org/article/d9a5a11c481f443f90c56186ddad5c93
Autor:
Xu Zhang, Daniel J Tyrrell, Tamara Alliston, Birgit Schilling, Matthew J Yousefzadeh, Marissa J Schafer
Publikováno v:
The Journals of Gerontology: Series A.
The National Institute on Aging (NIA) sponsored a symposium at the Gerontological Society of America (GSA) annual meeting in Indianapolis, Indiana to discuss recent discoveries related to senescent and inflammatory mechanisms in aging and disease. Co
Autor:
Chathurika Henpita, Rajesh Vyas, Chastity L. Healy, Tra L. Kieu, Aditi U. Gurkar, Matthew J. Yousefzadeh, Yuxiang Cui, Aiping Lu, Luise A. Angelini, Ryan D. O'Kelly, Sara J. McGowan, Sanjay Chandrasekhar, Rebecca R. Vanderpool, Danielle Hennessy‐Wack, Mark A. Ross, Timothy N. Bachman, Charles McTiernan, Smitha P. S. Pillai, Warren Ladiges, Mitra Lavasani, Johnny Huard, Donna Beer‐Stolz, Claudette M. St. Croix, Simon C. Watkins, Paul D. Robbins, Ana L. Mora, Eric E. Kelley, Yinsheng Wang, Timothy D. O'Connell, Laura J. Niedernhofer
Publikováno v:
Aging Cell. 22
Autor:
Christopher S. Morrow, Darcie L. Moore, Chung-Yang Yeh, Korbyn Dahlquist, Matthew J. Yousefzadeh, John M. Denu, Michaela E Murphy, Chathurika Henpita, Tadataka Tsuji, Reji Babygirija, Josef P. Clark, Yagna P. R. Jarajapu, Timothy W. Rhoads, Alexis Adrian, Heidi H. Pak, Claire E Richardson, Mariah Calubag, Cara L Green, Cristal M. Hill, Rong Yuan, Ankur Kumar, Michelle Sonsalla, Kishore Chittimalli, Christina D. Camell, Vinal Menon, Mark Bouska, Heather A. Simmons, Yun Zhu, Kyoo-A Lee, Dudley W. Lamming, Eric R McGregor, Hua Bai, Judith Simcox, Carolina Soto-Palma, Akilavalli Narasimhan
Publikováno v:
GeroScience
Autor:
Matthew J. Yousefzadeh, Dudley W. Lamming, Mariana M Herrerias, Heidi H. Pak, Cara L Green, Hua Bai, Josef P. Clark, Srijit Das, Peiduo Liu, Davis A. Englund, Daniella E. Chusyd, Veena Prahlad, Rogan A. Grant
Publikováno v:
J Gerontol A Biol Sci Med Sci
While the average human life span continues to increase, there is little evidence that this is leading to a contemporaneous increase in “healthy years” experienced by our aging population. Consequently, many scientists focus their research on und