Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Matthew J. Winter"'
Autor:
Aya Takesono, Sylvia Dimitriadou, Nathaniel J. Clark, Richard D. Handy, Sulayman Mourabit, Matthew J. Winter, Tetsuhiro Kudoh, Charles R. Tyler
Publikováno v:
Environment International, Vol 180, Iss , Pp 108227- (2023)
Zinc (Zn) is an essential metal present in numerous enzymes throughout the body, playing a vital role in animal and human health. However, the increasing use of zinc oxide nanomaterials (ZnONPs) in a diverse range of products has raised concerns rega
Externí odkaz:
https://doaj.org/article/f22f5e6b85b140d8ab1048f91c0a3700
Autor:
Dylan L. Windell, Sulayman Mourabit, Julian Moger, Stewart F. Owen, Matthew J. Winter, Charles R. Tyler
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 260, Iss , Pp 115019- (2023)
Gold nanoparticles (AuNPs) are widely used in biomedicine and their specific properties including, size, geometrics, and surface coating, will affect their fate and behaviour in biological systems. These properties are well studied for their intended
Externí odkaz:
https://doaj.org/article/ad7bde81009e42c78aaa07105d0de375
Autor:
Matthew J. Winter, Yosuke Ono, Jonathan S. Ball, Anna Walentinsson, Erik Michaelsson, Anna Tochwin, Steffen Scholpp, Charles R. Tyler, Steve Rees, Malcolm J Hetheridge, Mohammad Bohlooly-Y
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The clinical heterogeneity of heart failure has challenged our understanding of the underlying genetic mechanisms of this disease. In this respect, large-scale patient DNA sequencing studies have become an invaluable strategy for identifying potentia
Externí odkaz:
https://doaj.org/article/c5241e27f188422cbb46be887827542a
Autor:
Charles M. Hamilton, Matthew J. Winter, Luigi Margiotta-Casaluci, Stewart F. Owen, Charles R. Tyler
Publikováno v:
Environment International, Vol 162, Iss , Pp 107163- (2022)
The glucocorticosteroid, or glucocorticoid (GC), system is largely conserved across vertebrates and plays a central role in numerous vital physiological processes including bone development, immunomodulation, and modification of glucose metabolism an
Externí odkaz:
https://doaj.org/article/6617fc22e032468f85a1c6038420f608
Autor:
Sulayman Mourabit, Jennifer A. Fitzgerald, Robert P. Ellis, Aya Takesono, Cosima S. Porteus, Maciej Trznadel, Jeremy Metz, Matthew J. Winter, Tetsuhiro Kudoh, Charles R. Tyler
Publikováno v:
Environment International, Vol 133, Iss , Pp - (2019)
Background: Reactive oxygen species (ROS) arise as a result from, and are essential in, numerous cellular processes. ROS, however, are highly reactive and if left unneutralised by endogenous antioxidant systems, can result in extensive cellular damag
Externí odkaz:
https://doaj.org/article/15d294de008a404fa72c8868d401fd3d
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The zebrafish is rapidly emerging as a promising alternative in vivo model for the detection of drug-induced cardiovascular effects. Despite its increasing popularity, the ability of this model to inform the drug development process is often limited
Externí odkaz:
https://doaj.org/article/f2e60909622d4e189a4927678785dd08
Publikováno v:
Environmental Toxicology and Chemistry.
Publikováno v:
Environmental Science & Technology. 55:16299-16312
Antidepressants are one of the most commonly prescribed pharmaceutical classes for the treatment of psychiatric conditions. They act via modulation of brain monoaminergic signaling systems (predominantly serotonergic, adrenergic, dopaminergic) that s
Autor:
Piotr Grabowski, Jonathan S. Ball, Joseph Pinion, Andrew D. Randall, Jeremy Metz, Will S. Redfern, Malcolm J. Hetheridge, Marc Goodfellow, Matthew J. Winter, Charles R. Tyler, Karen Tse, Aya Takesono, Anna Tochwin, Maciej Trznadel
Publikováno v:
British Journal of Pharmacology. 178:2671-2689
BACKGROUND AND PURPOSE Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generate
Autor:
Aya Takesono, Paula Schirrmacher, Aaron Scott, Jon M. Green, Okhyun Lee, Matthew J. Winter, Tetsuhiro Kudoh, Charles R. Tyler
Publikováno v:
Development. 149
Estrogens are well-known to regulate development of sexual dimorphism of the brain; however, their role in embryonic brain development prior to sex-differentiation is unclear. Using estrogen biosensor zebrafish models, we found that estrogen activity