Výsledky vyhledávání - "Matthew J. White"

Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion

Autor: Matthew J. White, Kyle A. Jacobs, Tania Singh, Matthew L. Kutys

Publikováno v: bioRxiv

SUMMARYNotch receptors control tissue morphogenic processes that involve coordinated changes in cell architecture and gene expression, but how a single receptor can produce these diverse biological outputs is unclear. Here we employ a 3D organotypic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6b33c429f546b6179f3feffc43c79e
https://europepmc.org/articles/PMC9900753/

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Effect of Bicortical Interfragmentary Screw Size on the Fixation of Metacarpal Shaft Fractures: A 3-Dimensional-Printed Biomechanical Study

Autor: Matthew J. White, Tian Wang, William C. H. Parr, Bernard F. Schick, William R. Walsh

Publikováno v: Journal of Hand Surgery Global Online. 3:154-159

Purpose Spiral metacarpal fractures fixed with 2 non-lagged, interfragmentary cortical screws were tested to failure. The effect of screw size (1.2 mm, 1.5 mm, 2.0 mm, and 2.3 mm) on construct strength was tested in 3-point bending. Methods Three-dim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9710edaf290d8592bf505e2d5cc90ec0
https://doi.org/10.1016/j.jhsg.2021.01.003

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Investigating alkylated prodigiosenes and their Cu(II)-dependent biological activity: Interactions with DNA, antimicrobial and photoinduced anticancer activity

Autor: Matilda Kraft, Sylvia Wagner, Sebastian Doniz Kettenmann, Andrea T. Feßler, Stefan Schwarz, Nora Kulak, Gerhard D. Wieland, Karin Danz, Julien Colard-Thomas, Matthew J. White, Arno Wiehe

Prodigiosenes are a family of red pigments with versatile biological activity. Their tripyrrolic core structure has been modified many times in order to manipulate the spectrum of activity. We have been looking systematically at prodigiosenes substit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01acfa8ba639379f89f777d0b41dd6fc
https://publica.fraunhofer.de/handle/publica/415260

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Akademický článek

Functional significance of CD57 expression on human NK cells and relevance to disease

Autor: Carolyn M Nielsen, Matthew J White, Martin R Goodier, Eleanor M Riley

Publikováno v: Frontiers in Immunology, Vol 4 (2013)

Historically, human NK cells have been identified as CD3-CD56+CD16+/- lymphocytes. More recently it has been established that CD57 expression defines functionally discrete subpopulations of NK cells. On T cells, CD57 expression has been regarded as a

Externí odkaz: https://doaj.org/article/8be3024d91c645059112b8a87f00d673

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Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection

Autor: Ana L. Moldoveanu, Carolyn M. Nielsen, Alansana Darboe, Ana Rodriguez-Galan, Matthew J. White, Chiara Lusa, Ron H Behrens, Martin R. Goodier, Eleanor M. Riley

Publikováno v: Goodier, M R, Rodriguez-Galan, A, Lusa, C, Nielsen, C M, Darboe, A, Moldoveanu, A L, White, M J, Behrens, R & Riley, E M 2016, ' Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells : Impact of Human Cytomegalovirus Infection ', Journal of Immunology, vol. 197, no. 1, pp. 313-25 . https://doi.org/10.4049/jimmunol.1502049
The Journal of Immunology Author Choice

Human NK cells are activated by cytokines, immune complexes, and signals transduced via activating ligands on other host cells. After vaccination, or during secondary infection, adaptive immune responses can enhance both cytokine-driven and Ab-depend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d55b83646a6ff7b1ead4e560fa66df
https://doi.org/10.4049/jimmunol.1502049

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Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals

Autor: Matthew J. White, Chiara Lusa, Ana Rodriguez-Galan, Eleanor M. Riley, Christian Bottomley, Carolyn M. Nielsen, Scarlett E. G. Turner, Martin R. Goodier

Publikováno v: The Journal of Immunology Author Choice

NK cells contribute to postvaccination immune responses after activation by IL-2 from Ag-specific memory T cells or by cross-linking of the low-affinity IgG receptor, CD16, by Ag–Ab immune complexes. Sensitivity of NK cells to these signals from th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4336edae4d538abc4b2d722d344276b
http://europepmc.org/articles/PMC4416741

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Calorie Restriction Attenuates Terminal Differentiation of Immune Cells

Autor: Martin R. Goodier, Eleanor M. Riley, Daniel J. Pearce, Jennifer E. Morgan, Christian Bottomley, Matthew J. White, Asia-Sophia Wolf, Luisa Boldrin, Carolyn M. Nielsen, Charlotte Whitmore, Charlotte M. Beaver

Publikováno v: Frontiers in Immunology
White, M J, Beaver, C M, Goodier, M R, Bottomley, C, Nielsen, C M, Wolf, A-S F M, Boldrin, L, Whitmore, C, Morgan, J, Pearce, D J & Riley, E M 2017, ' Calorie Restriction Attenuates Terminal Differentiation of Immune Cells ', Frontiers in Immunology, vol. 7, pp. 667 . https://doi.org/10.3389/fimmu.2016.00667

Immune senescence is a natural consequence of ageing and may contribute to frailty and loss of homeostasis in later life. Calorie restriction increases healthy life-span in C57BL/6J (but not DBA/2J) mice but whether this is related to preservation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cef265ce1c7735ef59f09cda01d668

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Functional Plasticity of Antigen-Specific Regulatory T Cells in Context of Tumor

Autor: Matthew J. White, Caroline Addey, Lang Dou, David Coe, Julian Dyson, Jian-Guo Chai

Publikováno v: The Journal of Immunology. 186:4557-4564

Although polyclonal regulatory T cells (Tregs) that once expressed Foxp3 (ex-Tregs) derived from Foxp3+ Tregs have been described in homeostatic and autoimmune settings, little is known regarding the influence of the tumor environment on ex-Treg deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b704ed50900e14ed3055848c92ecd6
https://doi.org/10.4049/jimmunol.1003797

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The roles of antigen-specificity, responsiveness to transforming growth factor-β and antigen-presenting cell subsets in tumour-induced expansion of regulatory T cells

Autor: Caroline Addey, Jian-Guo Chai, Julian Dyson, David Coe, Matthew J. White, Elizabeth Simpson

Publikováno v: Immunology. 131:556-569

Summary In this study we investigated the impact of several factors on the expansion of natural regulatory T (nTreg) cells by tumours, including antigen specificity, transforming growth factor-β (TGF-β) signalling and the antigen-presenting cell su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02b53807b5ee5fcddcdc75a40e3c69e2
https://doi.org/10.1111/j.1365-2567.2010.03328.x

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Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy

Autor: Julian Dyson, David Coe, Shaima Begom, Matthew J. White, Caroline Addey, Jian-Guo Chai

Publikováno v: Cancer Immunology, Immunotherapy. 59:1367-1377

In vitro, engagement of GITR on Treg cells by the agonistic anti-GITR mAb, DTA-1, appears to abrogate their suppressive function. The consequence of in vivo engagement of GITR by DTA-1 is, however, less clear. In this study, we show that Treg cells i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d4c572148604d294c645e36ef4838e
https://doi.org/10.1007/s00262-010-0866-5

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