Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Matthew J. Seasock"'
Autor:
Phillip A Erice, Xinyan Huang, Matthew J Seasock, Matthew J Robertson, Hui-Ying Tung, Melissa A Perez-Negron, Shivani L Lotlikar, David B Corry, Farrah Kheradmand, Antony Rodriguez
Publikováno v:
eLife, Vol 13 (2024)
Environmental air irritants including nanosized carbon black (nCB) can drive systemic inflammation, promoting chronic obstructive pulmonary disease (COPD) and emphysema development. The let-7 microRNA (Mirlet7 miRNA) family is associated with IL-17-d
Externí odkaz:
https://doaj.org/article/c161f40b17ec42c4943649e65feb5480
Autor:
Ziyuan Ma, Matthew J. Seasock, Katalin Susztak, Shizheng Huang, Chengxiang Qiu, Tomohito Doke, Hongbo Liu, Xin Sheng, Matthew Palmer
Publikováno v:
Science Advances
Description
Integrated omics analysis (GWAS, eQTL, snATAC, and mouse genetic models) identified caspase-9 as a kidney disease risk gene.
Genome-wide association studies (GWAS) have identified hundreds of genetic risk regions for kidney dysf
Integrated omics analysis (GWAS, eQTL, snATAC, and mouse genetic models) identified caspase-9 as a kidney disease risk gene.
Genome-wide association studies (GWAS) have identified hundreds of genetic risk regions for kidney dysf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ce2ff5758d2bf0583f78ed0ce47b25
https://doi.org/10.1126/sciadv.abi8051
https://doi.org/10.1126/sciadv.abi8051
Autor:
Junnan Wu, Matthew J. Seasock, Pazit Beckerman, Jeffrey B. Kopp, Andreas Linkermann, Joseph Wahba, Xin Sheng, Jay J. Kuo, Katalin Susztak, Archana Raman, Steven S. Pullen, Carine M. Boustany-Kari, Nathan J Coffey, Ziyuan Ma, Matthew Palmer, Dorottya Laczkó
Publikováno v:
J Clin Invest
Coding variants in apolipoprotein L1 (APOL1), termed G1 and G2, can explain most excess kidney disease risk in African Americans; however, the molecular pathways of APOL1-induced kidney dysfunction remain poorly understood. Here, we report that expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17dd6eb1999cb9898ee39e78487de6a1
https://doi.org/10.1172/jci136329
https://doi.org/10.1172/jci136329
Autor:
Junnan Wu, Xin Sheng, Chengxiang Qiu, Todd L. Edwards, Matthew J. Seasock, Thomas M. Coffman, Katalin Susztak, Steven Vitale, Christopher D. Brown, Jacklyn N. Hellwege, Matthew Palmer, Yuting Guan, Kevin L. Duffin, Benjamin F. Voight, Adriana M. Hung, Mingyao Li, Myung K. Shin, Hongbo Liu, Zhen Miao, Ziyuan Ma, Steven S. Pullen
Publikováno v:
Nat Genet
The functional interpretation of genome-wide association studies (GWAS) is challenging due to the cell-type-dependent influences of genetic variants. Here, we generated comprehensive maps of expression quantitative trait loci (eQTLs) for 659 microdis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811c90ea7197028fb174cd66634d8857
https://europepmc.org/articles/PMC9338440/
https://europepmc.org/articles/PMC9338440/
Autor:
Hongbo Liu, Steven S. Pullen, Xin Sheng, Myung K. Shin, Katalin Susztak, Christopher D. Brown, Jacklyn N. Hellwege, Benjamin F. Voight, Junnan Wu, Todd L. Edwards, Matthew J. Seasock, Adriana M. Hung, Mingyao Li, Chengxiang Qiu, Ziyuan Ma, Matthew Palmer, Kevin L. Duffin, Zhen Miao, Thomas M. Coffman
The functional interpretation of GWAS remains challenging due to cell-type dependent influences of genetic variants.Here, we generated comprehensive maps of expression quantitative trait loci (eQTL) for 659 microdissected human kidney samples and ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5caef46e13f4ff9d21769e5f7a7171f4
https://doi.org/10.1101/2020.11.09.375592
https://doi.org/10.1101/2020.11.09.375592
Autor:
YoSon Park, Christopher D. Brown, Matthew Palmer, Steven S. Pullen, Matthew J. Seasock, Paolo Guarnieri, Wen-Chao Song, Chengxiang Qiu, Shizheng Huang, Carine M. Boustany-Kari, Katalin Susztak, Yi-An Ko, Julie Hawkins, Xiang Xi Xu, Jon Hill, Jihwan Park, Joshua S. Bryer
Publikováno v:
Nature medicine
Chronic kidney disease (CKD), a condition in which the kidneys are unable to clear waste products, affects 700 million people globally. Genome-wide association studies (GWASs) have identified sequence variants for CKD; however, the biological basis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd616b288e56698e3627a940fef2856
https://doi.org/10.1038/s41591-018-0194-4
https://doi.org/10.1038/s41591-018-0194-4
Autor:
Amit Verma, Chengxiang Qiu, Hongzhe Li, A. Ari Hakimi, Matthew Palmer, Xin Sheng, Matthew J. Seasock, Katalin Susztak, James Pullman, Yuting Guan, Caroline Gluck, Jihwan Park
In patients with diabetes mellitus, poor metabolic control has a long-lasting impact on kidney disease development. Epigenetic changes, including cytosine methylation, have been proposed as potential mediators of the long-lasting effect of adverse me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c76b954f8eed9b6a0c801b5586789f
https://europepmc.org/articles/PMC6629092/
https://europepmc.org/articles/PMC6629092/
Autor:
Yuri Persidsky, Servio H. Ramirez, Steven F. Merkel, Steven J Kaspin, Matthew J. Seasock, Nancy L. Reichenbach, Roshanak Razmpour, Allison M. Andrews, Dianne Langford, Evan M. Lutton, Lee Anne Cannella
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 38(5)
Endothelial cells (ECs) form the basis of the blood–brain barrier (BBB), a physical barrier that selectively restricts transport into the brain. In vitro models can provide significant insight into BBB physiology, mechanisms of human disease pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed711a2e4dc8bcc719e79b331404d3c
https://pubmed.ncbi.nlm.nih.gov/28534661
https://pubmed.ncbi.nlm.nih.gov/28534661