Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthew J. Scheffel"'
Autor:
Christina Voelkel-Johnson, Michael I. Nishimura, Shikhar Mehrotra, Elizabeth Garrett-Mayer, Patricia Simms, Gina Scurti, Matthew J. Scheffel
Legends for Supplementary Figures 1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82020a68e49173b15b6fdd19eb05c0b3
https://doi.org/10.1158/0008-5472.22413461.v1
https://doi.org/10.1158/0008-5472.22413461.v1
Autor:
Christina Voelkel-Johnson, Michael I. Nishimura, Shikhar Mehrotra, Elizabeth Garrett-Mayer, Patricia Simms, Gina Scurti, Matthew J. Scheffel
Supplementary Figure 2. Pretreatment of T cells with N-acetyl cysteine prevent TCR restimulation induced ROS accumulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7a57f6a311b17e00965f3b9b90363a
https://doi.org/10.1158/0008-5472.22413464.v1
https://doi.org/10.1158/0008-5472.22413464.v1
Autor:
Christina Voelkel-Johnson, Michael I. Nishimura, Shikhar Mehrotra, Elizabeth Garrett-Mayer, Patricia Simms, Gina Scurti, Matthew J. Scheffel
Supplementary Figure 1. The DNA damage pathway occurs in CD4+ TIL1383I TCR transduced cells upon antigen-specific TCR restimulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39aa441288b91d22ee9a349a9ee9a3ca
https://doi.org/10.1158/0008-5472.22413467
https://doi.org/10.1158/0008-5472.22413467
Autor:
Shikhar Mehrotra, Michael I. Nishimura, Christina Voelkel-Johnson, Chrystal M. Paulos, David J. Cole, Elizabeth-Garrett Mayer, Mark P. Rubinstein, Viswanathan Palanisamy, Kent Armenson, Kristi Helke, Matthew J. Scheffel, Harinarayanan Janakiraman, Kelly Moxley, Kristina Andrijauskaite, Mazen Al-Hommrani, Myroslawa Soloshchenko, Pravin Kesarwani, Paramita Chakraborty, Shilpak Chatterjee, Krishnamurthy Thyagarajan, Anirban Banerjee
Details for comparative characterization of phenotype and anti-tumor function between the p53-KO vs. WT T cells are included.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678ea85076a875cce2ec2a06cbe98002
https://doi.org/10.1158/0008-5472.22409327.v1
https://doi.org/10.1158/0008-5472.22409327.v1
Autor:
Shikhar Mehrotra, Michael I. Nishimura, Christina Voelkel-Johnson, Chrystal M. Paulos, David J. Cole, Elizabeth-Garrett Mayer, Mark P. Rubinstein, Viswanathan Palanisamy, Kent Armenson, Kristi Helke, Matthew J. Scheffel, Harinarayanan Janakiraman, Kelly Moxley, Kristina Andrijauskaite, Mazen Al-Hommrani, Myroslawa Soloshchenko, Pravin Kesarwani, Paramita Chakraborty, Shilpak Chatterjee, Krishnamurthy Thyagarajan, Anirban Banerjee
Repetitive stimulation of T-cell receptor (TCR) with cognate antigen results in robust proliferation and expansion of the T cells, and also imprints them with replicative senescence signatures. Our previous studies have shown that life-span and antit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab5bb6628739c77c95eca0e15f38750
https://doi.org/10.1158/0008-5472.c.6507755
https://doi.org/10.1158/0008-5472.c.6507755
Autor:
Shikhar Mehrotra, Michael I. Nishimura, Christina Voelkel-Johnson, Chrystal M. Paulos, David J. Cole, Elizabeth-Garrett Mayer, Mark P. Rubinstein, Viswanathan Palanisamy, Kent Armenson, Kristi Helke, Matthew J. Scheffel, Harinarayanan Janakiraman, Kelly Moxley, Kristina Andrijauskaite, Mazen Al-Hommrani, Myroslawa Soloshchenko, Pravin Kesarwani, Paramita Chakraborty, Shilpak Chatterjee, Krishnamurthy Thyagarajan, Anirban Banerjee
Details for comparative characterization of the phenotype, and anti-tumor function of p53-KO vs Wt T cells is included.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863db56b7c51f04bf1d1525be8a10a92
https://doi.org/10.1158/0008-5472.22409330
https://doi.org/10.1158/0008-5472.22409330
Autor:
Chrystal M. Paulos, Christina Voelkel-Johnson, Michael I. Nishimura, Elizabeth Garrett-Mayer, Megan M. Wyatt, Gina Scurti, Matthew J. Scheffel
Publikováno v:
Cancer Immunology, Immunotherapy. 67:691-702
Therapeutic outcomes for adoptive cell transfer (ACT) therapy are constrained by the quality of the infused T cells. The rapid expansion necessary to obtain large numbers of cells results in a more terminally differentiated phenotype with decreased d
Autor:
Pravin Kesarwani, Viswanathan Palanisamy, Kelly Moxley, Shikhar Mehrotra, Anirban Banerjee, Mazen Al-Hommrani, Myroslawa Soloshchenko, Matthew J. Scheffel, Shilpak Chatterjee, Paramita Chakraborty, Mark P. Rubinstein, Kristina Andrijauskaite, Michael I. Nishimura, David J. Cole, Kristi L. Helke, Harinarayanan Janakiraman, Krishnamurthy Thyagarajan, Christina Voelkel-Johnson, Elizabeth-Garrett Mayer, Chrystal M. Paulos, Kent Armenson
Publikováno v:
Cancer Research. 76:5229-5240
Repetitive stimulation of T-cell receptor (TCR) with cognate antigen results in robust proliferation and expansion of the T cells, and also imprints them with replicative senescence signatures. Our previous studies have shown that life-span and antit
Autor:
Matthew J. Scheffel, Ping Lu, Christina Voelkel-Johnson, Kristi L. Helke, Besim Ogretmen, Chrystal M. Paulos, Jacob S. Bowers, Elizabeth Garrett-Mayer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
Sphingolipids regulate critical cellular processes including inflammation. Ceramide, which serves a central role in sphingolipid metabolism, is generated by six ceramide synthases (CerS) that differ in substrate specificity. CerS6 preferentially gene
Autor:
Christina Voelkel-Johnson, Michael I. Nishimura, Patricia E. Simms, Elizabeth Garrett-Mayer, Gina Scurti, Shikhar Mehrotra, Matthew J. Scheffel
Although adoptive transfer of autologous tumor antigen–specific T-cell immunotherapy can produce remarkable clinical efficacy, most patients do not achieve durable complete responses. We hypothesized that reducing susceptibility of T cells to activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5d4a40e02700806c0cf4779a5bbfb9
https://europepmc.org/articles/PMC5074089/
https://europepmc.org/articles/PMC5074089/