The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

Autor: Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Serge Ducommun, Matthew J. Sanders, Joshua P. Nederveen, Rebecca J. Ford, Stephen L. Pinkosky, Logan K. Townsend, Robert M. Gutgesell, Rachel Lu, Kei Sakamoto, Gregory R. Steinberg

Publikováno v: Desjardins, E M, Smith, B K, Day, E A, Ducommun, S, Sanders, M J, Nederveen, J P, Ford, R J, Pinkosky, S L, Townsend, L K, Gutgesell, R M, Lu, R, Sakamoto, K & Steinberg, G R 2022, ' The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids ', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 48, e2119824119 . https://doi.org/10.1073/pnas.2119824119

Fatty acids are vital for the survival of eukaryotes, but when present in excess can have deleterious consequences. The AMP-activated protein kinase (AMPK) is an important regulator of multiple branches of metabolism. Studies in purified enzyme prepa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ff00af91b3737ddb124470677dad36
https://pubmed.ncbi.nlm.nih.gov/36409897

Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

Autor: Katyayanee Neopane, Natalie Kozlov, Florentina Negoita, Lisa Murray-Segal, Robert Brink, Ashfaqul Hoque, Ashley J. Ovens, Gavin Tjin, Luke M. McAloon, Dingyi Yu, Naomi X.Y. Ling, Matthew J. Sanders, Jonathan S. Oakhill, John W. Scott, Gregory R. Steinberg, Kim Loh, Bruce E. Kemp, Kei Sakamoto, Sandra Galic

Publikováno v: Neopane, K, Kozlov, N, Negoita, F, Murray-Segal, L, Brink, R, Hoque, A, Ovens, A J, Tjin, G, McAloon, L M, Yu, D, Ling, N X Y, Sanders, M J, Oakhill, J S, Scott, J W, Steinberg, G R, Loh, K, Kemp, B E, Sakamoto, K & Galic, S 2022, ' Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis ', Cell Reports, vol. 41, no. 12, 111862 . https://doi.org/10.1016/j.celrep.2022.111862

AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis and a therapeutic target for metabolic diseases. Co/post-translational N-myristoylation of glycine-2 (Gly2) of the AMPK β subunit has been suggested to regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785ffb05621c50ca77add3fec7ae522a
https://curis.ku.dk/ws/files/333631148/1_s2.0_S2211124722017582_main.pdf

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.

Autor: Jennifer M A Tullet, Caroline Araiz, Matthew J Sanders, Catherine Au, Alexandre Benedetto, Irene Papatheodorou, Emily Clark, Kathrin Schmeisser, Daniel Jones, Eugene F Schuster, Janet M Thornton, David Gems

Publikováno v: PLoS Genetics, Vol 10, Iss 2, p e1004109 (2014)

The DAF-16/FoxO transcription factor controls growth, metabolism and aging in Caenorhabditis elegans. The large number of genes that it regulates has been an obstacle to understanding its function. However, recent analysis of transcript and chromatin

Externí odkaz: https://doaj.org/article/3555a38cc4584a5d9b789216555d1390

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

Autor: Jonathan S. Oakhill, Qian Ouyang, Mads Kjolby, Jens Stolte, John W. Scott, Ashley J. Ovens, Mathieu Membrez, Niels Jessen, Amy M. Ehrlich, Julian M. Yabut, Eric M. Desjardins, Shuai Chen, Jonas T. Treebak, Pascal Maire, Danial Ahwazi, Ping Rong, Philipp Rhein, José L. Sanchez Garcia, Kei Sakamoto, Gregory R. Steinberg, Patrick Descombes, Matthew J. Sanders, Nicolas Bonhoure, Matthieu Dos Santos

Publikováno v: Rhein, P, Desjardins, E M, Rong, P, Ahwazi, D, Bonhoure, N, Stolte, J, Santos, M D, Ovens, A J, Ehrlich, A M, Sanchez Garcia, J L, Ouyang, Q, Yabut, J M, Kjolby, M, Membrez, M, Jessen, N, Oakhill, J S, Treebak, J T, Maire, P, Scott, J W, Sanders, M J, Descombes, P, Chen, S, Steinberg, G R & Sakamoto, K 2021, ' Compound-and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle ', Molecular Metabolism, vol. 51, 101228 . https://doi.org/10.1016/j.molmet.2021.101228
Molecular Metabolism
Molecular Metabolism, Vol 51, Iss, Pp 101228-(2021)
Rhein, P, Desjardins, E M, Rong, P, Ahwazi, D, Bonhoure, N, Stolte, J, Santos, M D, Ovens, A J, Ehrlich, A M, Sanchez Garcia, J L, Ouyang, Q, Yabut, J M, Kjolby, M F, Membrez, M, Jessen, N, Oakhill, J S, Treebak, J T, Maire, P, Scott, J W, Sanders, M J, Descombes, P, Chen, S, Steinberg, G R & Sakamoto, K 2021, ' Compound-and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle ', Molecular Metabolism, vol. 51, 101228 . https://doi.org/10.1016/j.molmet.2021.101228

Objective The metabolic master-switch AMP-activated protein kinase (AMPK) mediates insulin-independent glucose uptake in muscle and regulates the metabolic activity of brown and beige adipose tissue (BAT). The regulatory AMPKγ3 isoform is uniquely e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4278f7f47cec68c420f9710104a116
https://curis.ku.dk/ws/files/276699251/1_s2.0_S2212877821000739.pdf

Treatment of Common Iliac Arteries in Preparation for Kidney Transplant, What Is the Evidence? A 5-Year Review in One Institution

Autor: Matthew J. Sanders, Jorge Rey

Publikováno v: Annals of Vascular Surgery. 52:11-12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c67e01dc171f939043d5c27eea2a0e25
https://doi.org/10.1016/j.avsg.2018.07.021