Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Matthew J. Saabye"'
Autor:
Ke Sherry Li, John G. Quinn, Matthew J. Saabye, Jesus F. Salcido Guerrero, Jim Nonomiya, Qihui Lian, Wilson Phung, Yevgeniy Izrayelit, Benjamin T. Walters, Amy Gustafson, Nicholas F. Endres, Maureen H. Beresini, Melinda M. Mulvihill
Publikováno v:
Analytical Chemistry. 94:1230-1239
Autor:
Ke Sherry, Li, John G, Quinn, Matthew J, Saabye, Jesus F Salcido, Guerrero, Jim, Nonomiya, Qihui, Lian, Wilson, Phung, Yevgeniy, Izrayelit, Benjamin T, Walters, Amy, Gustafson, Nicholas F, Endres, Maureen H, Beresini, Melinda M, Mulvihill
Publikováno v:
Analytical chemistry. 94(2)
With recent advances and success in several drugs designed to treat acute and chronic diseases, targeted covalent inhibitors show a resurgence in drug discovery. As covalent inhibition is time-dependent, the preferred quantitative potency metric of i
Autor:
E. Jon Jacobsen, Matthew J. Saabye, Chun Wang, Jeffrey L. Hirsch, Sheri L. Bonar, Gabriel Mbalaviele, Shaun R. Selness, Hal M. Hoffman, Susan L. Hockerman, Yael Alippe, Joseph B. Monahan, William F. Hood, Stephen J. Mnich, Yousef Abu-Amer, Ariela Haimovich, Heidi R. Hope
Publikováno v:
The Journal of Experimental Medicine
A unique p38α MAPK–MK2 pathway inhibitor, CDD-450, is used to uncover the function of this protein complex in inflammasome priming signals. Importantly, CDD-450 is as efficacious as global p38α MAPK inhibitors in decreasing inflammation in diseas
Autor:
Maureen K. Highkin, Matthew D. McReynolds, Matthew J. Saabye, John W. Rains, Kaliapan Iyanar, Jeffrey Carroll, Jill Chrencik, Matthew P. Yates, Jeffrey A. Scholten, Gina M. Jerome, Marek M. Nagiec, Mark E. Schnute
Publikováno v:
Journal of medicinal chemistry. 60(6)
Sphingosine kinase (SphK) is the major source of the lipid mediator and G protein-coupled receptor agonist sphingosine-1-phosphate (S1P). S1P promotes cell growth, survival, and migration and is a key regulator of lymphocyte trafficking. Inhibition o
Autor:
Michelle Kraus, Jay M. Wendling, Olga V. Nemirovskiy, John W. Rains, Vincent Peterkin, Laura E. Zawadzke, Hideji Fujiwara, Ciarán N. Cronin, Troii Hall, Tom Kasten, Maureen K. Highkin, Gina M. Jerome, Arthur J. Wittwer, Matthew P. Yates, Shinji Ogawa, Jeffrey A. Scholten, Jill Chrencik, Marek M. Nagiec, Matthew D. McReynolds, Kaliapan Iyanar, Mark E. Schnute, Kristin Cukyne, Matthew J. Saabye, Richard M. Broadus
Publikováno v:
Biochemical Journal. 444:79-88
SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhi
Autor:
Dean Messing, Brian S. Hickory, Alan G. Benson, Matthew J. Saabye, Jeff Hitchcock, Heather M. Madsen, Devadas Balekudru, Shaun R. Selness, Richard C. Durley, Laura D. Marrufo, Gary D. Anderson, Li Xing, Kevin D. Jerome, Michael Hepperle, Christie Lance Christopher, Rajesh V. Devraj, Elizabeth G. Webb, Thomas Owen, Ravi G. Kurumbail, Edgardo Alvira, Jeffrey L. Hirsch, Joseph B. Monahan, Paul V. Rucker, Boehm Terri L, Blevis-Bal Radhika M, Huey S. Shieh, John K. Walker, John F. Schindler, Michele A. Promo, Win Naing, Sheri L. Bonar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4059-4065
A series of N-aryl pyridinone inhibitors of p38 mitogen activated protein (MAP) kinase were designed and prepared based on the screening hit SC-25028 (1) and structural comparisons to VX-745 (5). The focus of the investigation targeted the dependence
Autor:
Robert J. Mourey, Matthew J. Saabye, Marvin J. Meyers, J. Scott Daniels, William F. Hood, Stephen J. Mnich, Jian Zhang, Jeffrey L. Hirsch, Sarah J. Brustkern, Betsy Pierce, Barry L. Burnette, David R. Anderson, John F. Schindler, Elizabeth G. Webb, Sarah A. South
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 333:797-807
Activation of the p38 kinase pathway in immune cells leads to the transcriptional and translational regulation of proinflammatory cytokines. Mitogen-activated protein kinase-activated protein kinase 2 (MK2), a direct downstream substrate of p38 kinas
Autor:
Thomas L. Emmons, James R. Kiefer, Joseph W. Leone, John F. Schindler, Melissa S. Harris, Jacqueline E. Day, Siradanahalli Guru, Alfredo G. Tomasselli, Robin A. Weinberg, Sandra Lightle, H. David Fischer, Jeffrey L. Hirsch, Jill Chrencik, Jennifer A. Gormley, Jennifer M. Williams, Matthew J. Saabye, Troii Hall
Publikováno v:
Protein Expression and Purification. 69:54-63
Janus-associated kinases (JAKs) play critical roles in cytokine signaling, and have emerged as viable therapeutic targets in inflammation and oncology related diseases. To date, targeting JAK proteins with highly selective inhibitor compounds have re
Autor:
Shashi K. Ramaiah, Christie L. Funckes-Shippy, Nandini Kishore, Xiong Li, James D. Warner, Jeffrey L. Hirsch, Michael I. Jesson, Dale L. Morris, Debra M. Meyer, Matthew J. Saabye, Mollisa M. Elrick, Cindy J. Gross, Jennifer L Barks, Martin E. Dowty
Publikováno v:
Journal of Inflammation, Vol 7, Iss 1, p 41 (2010)
Journal of Inflammation (London, England)
Journal of Inflammation (London, England)
Background The Janus kinase (JAK) family of tyrosine kinases includes JAK1, JAK2, JAK3 and TYK2, and is required for signaling through Type I and Type II cytokine receptors. CP-690,550 is a potent and selective JAK inhibitor currently in clinical tri
Autor:
Gabriel Mbalaviele, Rajesh V. Devraj, Elizabeth G. Webb, Jeffrey L. Hirsch, Heidi R. Hope, Matthew J. Saabye, Dean Messing, Jian Zhang, Joseph B. Monahan, Shaun R. Selness, John F. Schindler, Loreen Stillwell, Barry L. Burnette, Gary D. Anderson, Robert P. Compton, Xiong Li, Robert H. Keith
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 331(3)
Signal transduction through the p38 mitogen-activated protein (MAP) kinase pathway is central to the transcriptional and translational control of cytokine and inflammatory mediator production. p38 MAP kinase inhibition hence constitutes a promising t