Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Matthew J. Riese"'
Autor:
Emily P. Vonderhaar, Nicholas S. Barnekow, Donna McAllister, Laura McOlash, Mahmoud Abu Eid, Matthew J. Riese, Vera L. Tarakanova, Bryon D. Johnson, Michael B. Dwinell
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 41-58 (2021)
Background & Aims: Pancreatic ductal adenocarcinoma (PDA) is a lethal chemoresistant cancer that exhibits early metastatic spread. The highly immunosuppressive PDA tumor microenvironment renders patients resistant to emerging immune-targeted therapie
Externí odkaz:
https://doaj.org/article/040336860c1f40a1a33eef7faad56fe7
Autor:
Chao Yang, Jason R. Siebert, Robert Burns, Zachary J. Gerbec, Benedetta Bonacci, Amy Rymaszewski, Mary Rau, Matthew J. Riese, Sridhar Rao, Karen-Sue Carlson, John M. Routes, James W. Verbsky, Monica S. Thakar, Subramaniam Malarkannan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Natural killer (NK) cells are important innate immune cells with diverse functions. Here the authors use single-cell RNA-sequencing of purified human bone marrow and peripheral blood NK cells to define five populations of NK cells with distinct trans
Externí odkaz:
https://doaj.org/article/c0d7b97edd22455d8504f80ccc09c6b8
Autor:
Junchen Gu, Cindy Wang, Carolyn Cao, Jinwen Huang, Sandra Holzhauer, Heshani Desilva, Erin M. Wesley, Douglas B. Evans, Joseph Benci, Michael Wichroski, Susan Wee, Matthew J. Riese
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T cells. A direct comparison of tumor growth between mice lacking each isoform has not been
Externí odkaz:
https://doaj.org/article/5d3031950b2e4b1aa8390e28fad5c75f
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101580- (2020)
Summary: Immunotherapy with monoclonal antibodies targeting immune checkpoint molecules, including programmed death-1 (PD-1), PD ligand-1 (PD-L1), and cytotoxic T-lymphocyte-associated antigen (CTLA)-4, has become prominent in the treatment of many t
Externí odkaz:
https://doaj.org/article/8abed9206ec94d0a93eae1568c9fd57d
Autor:
Zachary J. Gerbec, Elaheh Hashemi, Arash Nanbakhsh, Sandra Holzhauer, Chao Yang, Ao Mei, Shirng-Wern Tsaih, Angela Lemke, Michael J. Flister, Matthew J. Riese, Monica S. Thakar, Subramaniam Malarkannan
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101454- (2020)
Summary: During an immune response, natural killer (NK) cells activate specific metabolic pathways to meet the increased energetic and biosynthetic demands associated with effector functions. Here, we found in vivo activation of NK cells during Liste
Externí odkaz:
https://doaj.org/article/9cfd2343a8df4691b8cafb60fbcdcdf6
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1 (2019)
Pancreatic cancer is characterized by an immune suppressive stromal reaction that creates a barrier to therapy. A murine transgenic pancreatic cancer cell line that recapitulates human disease was used to test whether a STimulator of Interferon Genes
Externí odkaz:
https://doaj.org/article/b450b376720746a2926f94882071345b
Autor:
David L. Bajor, Rosemarie Mick, Matthew J. Riese, Alex C. Huang, Brendan Sullivan, Lee P. Richman, Drew A. Torigian, Sangeeth M. George, Erietta Stelekati, Fang Chen, J. Joseph Melenhorst, Simon F. Lacey, Xiaowei Xu, E. John Wherry, Tara C. Gangadhar, Ravi K. Amaravadi, Lynn M. Schuchter, Robert H. Vonderheide
Publikováno v:
OncoImmunology, Vol 7, Iss 10 (2018)
We report long-term clinical outcomes and immune responses observed from a phase 1 trial of agonist CD40 monoclonal antibody (mAb) and blocking CTLA-4 mAb in patients with metastatic melanoma. Twenty-four patients previously untreated with checkpoint
Externí odkaz:
https://doaj.org/article/db6c0d6d585d48869cc793dff12ef78a
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 23, p 5821 (2019)
It is well established that extracellular proteins that negatively regulate T cell function, such as Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4) and Programmed Cell Death protein 1 (PD-1), can be effectively targeted to enhance cancer immuno
Externí odkaz:
https://doaj.org/article/a97e8dbe5de440aaaa1cadb0320457e0
Autor:
Richard A. Miller, Stephen B. Willingham, Long Kwei, Ian McCaffery, Jessica Hsieh, Po Y. Ho, Brian Munneke, Rachel A. Goodwin, Daniel J. Renouf, Lyudmyla Berim, Jonathan W. Goldman, Philip Bonomi, Leonel Hernandez-Aya, Joshua D. Brody, Ginna Laport, Jason J. Luke, Daruka Mahadevan, Leisha A. Emens, Ben Markman, Matthew J. Riese, Amy M. Weise, Shivaani Kummar, Brian I. Rini, Dale R. Shepard, Matthew D. Hellmann, Brett G.M. Hughes, Saby George, Toni K. Choueiri, Rebecca S. Heist, Mario Sznol, John D. Powderly, Andrew Hotson, Lawrence Fong
Adenosine mediates immunosuppression within the tumor microenvironment through triggering adenosine 2A receptors (A2AR) on immune cells. To determine whether this pathway could be targeted as an immunotherapy, we performed a phase I clinical trial wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a4eb0824258054770e529fd0c7d5f1
https://doi.org/10.1158/2159-8290.c.6547840.v1
https://doi.org/10.1158/2159-8290.c.6547840.v1
Autor:
Richard A. Miller, Stephen B. Willingham, Long Kwei, Ian McCaffery, Jessica Hsieh, Po Y. Ho, Brian Munneke, Rachel A. Goodwin, Daniel J. Renouf, Lyudmyla Berim, Jonathan W. Goldman, Philip Bonomi, Leonel Hernandez-Aya, Joshua D. Brody, Ginna Laport, Jason J. Luke, Daruka Mahadevan, Leisha A. Emens, Ben Markman, Matthew J. Riese, Amy M. Weise, Shivaani Kummar, Brian I. Rini, Dale R. Shepard, Matthew D. Hellmann, Brett G.M. Hughes, Saby George, Toni K. Choueiri, Rebecca S. Heist, Mario Sznol, John D. Powderly, Andrew Hotson, Lawrence Fong
Supplemental Appendix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3071ba39347d3fcb4739fac2eed11e81
https://doi.org/10.1158/2159-8290.22535371.v1
https://doi.org/10.1158/2159-8290.22535371.v1