Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Matthew J. Ranaghan"'
Autor:
Colin W. Garvie, Xiaoyun Wu, Malvina Papanastasiou, Sooncheol Lee, James Fuller, Gavin R. Schnitzler, Steven W. Horner, Andrew Baker, Terry Zhang, James P. Mullahoo, Lindsay Westlake, Stephanie H. Hoyt, Marcus Toetzl, Matthew J. Ranaghan, Luc de Waal, Joseph McGaunn, Bethany Kaplan, Federica Piccioni, Xiaoping Yang, Martin Lange, Adrian Tersteegen, Donald Raymond, Timothy A. Lewis, Steven A. Carr, Andrew D. Cherniack, Christopher T. Lemke, Matthew Meyerson, Heidi Greulich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The small molecule DNMDP acts as a velcrin by inducing complex formation between phosphodiesterase PDE3A and SLFN12, which kills cancer cells that express sufficient levels of both proteins. Here, the authors present the cryo-EM structure of the DNMD
Externí odkaz:
https://doaj.org/article/8c9d393dbd6b4b13a8ba16d21da8b36d
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background Custom genes have become a common resource in recombinant biology over the last 20 years due to the plummeting cost of DNA synthesis. These genes are often “optimized” to non-native sequences for overexpression in a non-native
Externí odkaz:
https://doaj.org/article/2cb4ebcfec69417d87699da3fdff6230
Autor:
Dale Porter, Alessandra Ianari, Merissa Brousseau, Patrick McCarren, Foxy P. Robinson, Adam Skepner, Virendar K. Kaushik, Kathleen M. Mulvaney, Arthur J. Campbell, Martin J Drysdale, Zachary Mullin-Bernstein, Brian J. McMillan, Robert Hilgraf, Ritu Singh, Matthew J. Ranaghan, Meghan O’Keefe, William R. Sellers, David C. McKinney, Jamie A. Moroco, Michael F. Mesleh, David E. Timm, Besnik Bajrami, Florence F. Wagner
Publikováno v:
J Med Chem
PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5 binding motif (PBM) which mediates binding to a surface of PRMT5 distal to the catalytic si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2c09646bd9e9db576eb95fa59b4da5
https://doi.org/10.1021/acs.jmedchem.1c00507
https://doi.org/10.1021/acs.jmedchem.1c00507
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-13 (2021)
BMC Biology
BMC Biology
Background Custom genes have become a common resource in recombinant biology over the last 20 years due to the plummeting cost of DNA synthesis. These genes are often “optimized” to non-native sequences for overexpression in a non-native host by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aee6b9a145b1df30551c9e9bc5f5c25
https://doaj.org/article/2cb4ebcfec69417d87699da3fdff6230
https://doaj.org/article/2cb4ebcfec69417d87699da3fdff6230
Autor:
Jordan A. Greco, Nicole L. Wagner, Ralph J. Jensen, Daniel J. Sandberg, Matthew J. Ranaghan, Megan N. Sandberg, Robert R. Birge, Daniel B Lawrence
Publikováno v:
J Neural Eng
Objective. Biomimetic protein-based artificial retinas offer a new paradigm for restoring vision for patients blinded by retinal degeneration. Artificial retinas, comprised of an ion-permeable membrane and alternating layers of bacteriorhodopsin (BR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2b71a112813296b1ab10abe3c760bd
https://europepmc.org/articles/PMC8666970/
https://europepmc.org/articles/PMC8666970/
Autor:
Andrew J. Aguirre, Nischal Acharya, Adam Skepner, Christa Blomquist, David C. McKinney, Michael J. Young, Meghan O’Keefe, Ruitong Li, Debjani Pal, Kathleen M. Mulvaney, Yelena Freyzon, Matthew E. Stokes, Fazli K. Bozal, Donald Raymond, Matthew J. Ranaghan, Devishi Kesar, Diego J. Rodriguez, Yossef Baidi, Annan Yang, William R. Sellers, Sidharth S. Jain, Dale Porter, Salvatore LaRussa, Alessandra Ianari, Josie Columbus, Zachary Mullin-Bernstein, Alissa J. Nelson, Brian J. McMillan
Publikováno v:
Mol Cell
PRMT5 is an essential arginine methyltransferase and a therapeutic target in MTAP-null cancers. PRMT5 uses adaptor proteins for substrate recruitment through a previously undefined mechanism. Here, we identify an evolutionarily conserved peptide sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c286957885746d63e5b3ac89688c8b85
https://europepmc.org/articles/PMC9016627/
https://europepmc.org/articles/PMC9016627/
Autor:
Adrian Tersteegen, Stephanie H. Hoyt, Steven A. Carr, Donald Raymond, Christopher T. Lemke, Federica Piccioni, James Mullahoo, Martin Lange, Xiaoping Yang, Bethany Kaplan, Colin W. Garvie, Andrew Baker, Marcus Toetzl, Heidi Greulich, Malvina Papanastasiou, Steven Horner, Luc de Waal, Timothy A. Lewis, James R. Fuller, Sooncheol Lee, Lindsay Westlake, Andrew D. Cherniack, Joseph McGaunn, Terry Zhang, Gavin R. Schnitzler, Matthew Meyerson, Matthew J. Ranaghan, Xiaoyun Wu
Publikováno v:
'Nature Communications ', vol: 12, pages: 4375-1-4375-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
DNMDP and related compounds, or velcrins, induce complex formation between the phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response in cancer cells that express elevated levels of both proteins. The mechanisms by which velc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfd121cbb4144ac667f5c20f822fddc
https://doi.org/10.1038/s41467-021-24495-w
https://doi.org/10.1038/s41467-021-24495-w
Autor:
Ritu Singh, Michael F. Mesleh, Matthew J. Ranaghan, Virendar K. Kaushik, Dale Porter, Brian J. McMillan, Kathleen M. Mulvaney, Alessandra Ianari, David E. Timm, William R. Sellers, Besnik Bajrami, Patrick McCarren, Meghan O’Keefe, David C. McKinney, Merissa Brousseau, Zachary Mullin-Bernstein, Jamie A. Moroco, Adam Skepner
PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5 binding motif (PBM) which mediates binding to a surface of PRMT5 distal to the catalytic si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b6860a9dce9163efa6957c5be29c743
https://doi.org/10.1101/2021.02.03.429644
https://doi.org/10.1101/2021.02.03.429644
Autor:
Yossef Baidi, Brian J. McMillan, Alissa J. Nelson, Josie Columbus, Sidharth S. Jain, Nischal Acharya, Matthew J. Ranaghan, Meghan O’Keefe, William R. Sellers, Kathleen M. Mulvaney, Yelena Freyzon, Fazli K. Bozal, Christa Blomquist, Ruitong Li, Adam Skepner, David C. McKinney, Dale Porter, Alessandra Ianari, Donald Raymond, Matthew E. Stokes
PRMT5 is an arginine methyltransferase and a therapeutic target in MTAP null cancers. PRMT5 utilizes adaptor proteins for substrate recruitment through a previously undefined mechanism. Here, we identify an evolutionarily conserved peptide sequence s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45336005291024a9907c2480940f06f2
https://doi.org/10.1101/2020.08.22.256347
https://doi.org/10.1101/2020.08.22.256347
Autor:
Yongjie Wei, José Carlos Rodríguez Pérez, Jenna B. Yehl, Matthew J. Ranaghan, Beth Levine, Zhongju Zou, Bruce A. Posner, Yi Chun Kuo, Adam Skepner, Shuguang Wei, Joshua A. Bittker, Wei Chung Chiang, Anwu Zhou
Publikováno v:
ACS Chemical Biology. 13:2247-2260
Autophagy, a lysosomal degradation pathway, plays a crucial role in cellular homeostasis, development, immunity, tumor suppression, metabolism, prevention of neurodegeneration, and lifespan extension. Thus, pharmacological stimulation of autophagy ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d32968767908610b571a31f23d5500
https://doi.org/10.1021/acschembio.8b00421
https://doi.org/10.1021/acschembio.8b00421