Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Matthew J. Potthoff"'
Autor:
Sarah H. Bjorkman, Alex Marti, Jayashree Jena, Luis Miguel García-Peña, Eric T. Weatherford, Kevin Kato, Jivan Koneru, Jason Chen, Ayushi Sood, Matthew J. Potthoff, Christopher M. Adams, E. Dale Abel, Renata O. Pereira
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21). Induction of ATF4 in BAT in response to mitochondrial stress is requ
Externí odkaz:
https://doaj.org/article/438fdd6b7f334f3d84b2767d8e8eb602
Autor:
Thao D.V. Le, Payam Fathi, Amanda B. Watters, Blair J. Ellis, Gai-Linn K. Besing, Nadejda Bozadjieva-Kramer, Misty B. Perez, Andrew I. Sullivan, Jesse P. Rose, Laurie L. Baggio, Jacqueline Koehler, Jennifer L. Brown, Michelle B. Bales, Kaitlyn G. Nwaba, Jonathan E. Campbell, Daniel J. Drucker, Matthew J. Potthoff, Randy J. Seeley, Julio E. Ayala
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101718- (2023)
Objective: Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RA) and fibroblast growth factor-21 (FGF21) confer similar metabolic benefits. GLP-1RA induce FGF21, leading us to investigate mechanisms engaged by the GLP-1RA liraglutide to increa
Externí odkaz:
https://doaj.org/article/d72c33cca2fa47dca8da218c427827be
Autor:
Kristin E. Claflin, Andrew I. Sullivan, Meghan C. Naber, Kyle H. Flippo, Donald A. Morgan, Tate J. Neff, Sharon O. Jensen-Cody, Zhiyong Zhu, Leonid V. Zingman, Kamal Rahmouni, Matthew J. Potthoff
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101564- (2022)
Objective: Fibroblast growth factor 21 (FGF21) is a peripherally-derived endocrine hormone that acts on the central nervous system (CNS) to regulate whole body energy homeostasis. Pharmacological administration of FGF21 promotes weight loss in obese
Externí odkaz:
https://doaj.org/article/a8e4a7c289724231bd231b8d8c5ecffa
Autor:
Kristin E. Claflin, Kyle H. Flippo, Andrew I. Sullivan, Meghan C. Naber, Bolu Zhou, Tate J. Neff, Sharon O. Jensen-Cody, Matthew J. Potthoff
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101405- (2022)
Objective: Uncoupling protein 1 (UCP1) is a mitochondrial protein critical for adaptive thermogenesis in adipose tissues, and it is typically believed to be restricted to thermogenic adipose tissues. UCP1-Cre transgenic mice are utilized in numerous
Externí odkaz:
https://doaj.org/article/0181f3168d184f27a7b3016bbffc15fb
Autor:
Sara C. Sebag, Zeyuan Zhang, Qingwen Qian, Mark Li, Zhiyong Zhu, Mikako Harata, Wenxian Li, Leonid V. Zingman, Limin Liu, Vitor A. Lira, Matthew J. Potthoff, Alexander Bartelt, Ling Yang
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110003- (2021)
Summary: Brown adipose tissue (BAT) thermogenic activity is tightly regulated by cellular redox status, but the underlying molecular mechanisms are incompletely understood. Protein S-nitrosylation, the nitric-oxide-mediated cysteine thiol protein mod
Externí odkaz:
https://doaj.org/article/fa993ffe513b402bb490e9e9850283d2
Autor:
Jaimarie Sostre-Colón, Kahealani Uehara, Anna E. Garcia Whitlock, Matthew J. Gavin, Jeff Ishibashi, Matthew J. Potthoff, Patrick Seale, Paul M. Titchenell
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109128- (2021)
Summary: Organismal stressors such as cold exposure require a systemic response to maintain body temperature. Brown adipose tissue (BAT) is a key thermogenic tissue in mammals that protects against hypothermia in response to cold exposure. Defining t
Externí odkaz:
https://doaj.org/article/289a3505422f4442b608e9054f528a9d
Publikováno v:
Cells, Vol 11, Iss 9, p 1565 (2022)
The ability to maintain energy homeostasis is necessary for survival. Recently, an emerging role for ependymogial cells, which line the third ventricle in the hypothalamus in the regulation of energy homeostasis, has been appreciated. These cells are
Externí odkaz:
https://doaj.org/article/3bf9498736844d10b9925d94f177a9e6
Autor:
Kathleen R. Markan, Lauren K. Boland, Abdul Qaadir King-McAlpin, Kristin E. Claflin, Michael P. Leaman, Morgan K. Kemerling, Madison M. Stonewall, Brad A. Amendt, James A. Ankrum, Matthew J. Potthoff
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101148- (2021)
Externí odkaz:
https://doaj.org/article/b63cdee36756479d8cc1b2910233feef
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101138- (2021)
Background: The liver is a key regulator of systemic energy homeostasis and can sense and respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation of systemic energy homeostasis by the liver is mediated in part th
Externí odkaz:
https://doaj.org/article/605c1f64d3154a60ab667d0c7b2a7b22
Autor:
Kathleen R. Markan, Lauren K. Boland, Abdul Qaadir King-McAlpin, Kristin E. Claflin, Michael P. Leaman, Morgan K. Kemerling, Madison M. Stonewall, Brad A. Amendt, James A. Ankrum, Matthew J. Potthoff
Publikováno v:
Molecular Metabolism, Vol 36, Iss , Pp - (2020)
Objective: T-box 1 (TBX1) has been identified as a genetic marker of beige adipose tissue. TBX1 is a mesodermal development transcription factor essential for tissue patterning and cell fate determination. However, whether it plays a role in the proc
Externí odkaz:
https://doaj.org/article/ce6dac942e13458db2784760abaedbf8