Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Matthew J. Mulder"'
Autor:
Christopher C. Presley, Charles K. Perry, Elizabeth S. Childress, Matthew J. Mulder, Vincent B. Luscombe, Alice L. Rodriguez, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley
Publikováno v:
ACS Omega, Vol 4, Iss 7, Pp 12782-12789 (2019)
Externí odkaz:
https://doaj.org/article/5fdf499332094c6c9828c3faab3a798f
Autor:
Colleen M. Niswender, Christopher C Presley, P. Jeffrey Conn, Vincent B. Luscombe, Alice L. Rodriguez, Charles K. Perry, Craig W. Lindsley, Matthew J. Mulder, Elizabeth S. Childress
Publikováno v:
ACS Omega, Vol 4, Iss 7, Pp 12782-12789 (2019)
Allosteric ligands within a given chemotype can have the propensity to display a wide range of pharmacology, as well as unexpected changes in GPCR subtype selectivity, typically mediated by single-atom modifications to the ligand. Due to the unexpect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d507940bc2a7cff2b1f11bcdaff15da0
https://doi.org/10.1021/acsomega.9b02017
https://doi.org/10.1021/acsomega.9b02017
Autor:
Savannah J. Post, Liping Tang, Matthew J. Mulder, Christina A. Le, Mark Turlington, Stephen G. Aller, Steven M. Rowe, Gary W. Breton, Sichen Chang, Britton K. Ody, Jonathon B. Brace, Jake E. Doiron, Harrison M. Hill, Wei Wang, Nathan L. Thacker, Thomas M. Bridges
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 25(14)
The 1,2,3-triazole has been successfully utilized as an amide bioisostere in multiple therapeutic contexts. Based on this precedent, triazole analogues derived from VX-809 and VX-770, prominent amide-containing modulators of the cystic fibrosis trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e74072f169b81c8dc63a7e650da7af
https://pubmed.ncbi.nlm.nih.gov/30650214
https://pubmed.ncbi.nlm.nih.gov/30650214
Autor:
Meredith J. Noetzel, Craig W. Lindsley, Brian J. Smith, Tao Qu, Gary A. Sulikowski, Matthew J. Mulder
Publikováno v:
Tetrahedron. 66:4805-4810
The total synthesis of tetrahydrohaliclonacyclamine A (5) is described. A key step involves the hydrogenation of an unsaturated bis-piperidine incorporated into a 17-membered macrocycle to provide the cis–syn–cis stereochemistry common to haliclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e43b462748c6399fca889b70dad6676e
https://doi.org/10.1016/j.tet.2010.03.117
https://doi.org/10.1016/j.tet.2010.03.117
Autor:
Thomas M. Bridges, Lyndsey Williams, L. Michelle Lewis, Richard Williams, Colleen M. Niswender, J. Phillip Kennedy, Craig W. Lindsley, Natalia T. Nalywajko, Matthew J. Mulder, P. Jeffrey Conn, John T. Brogan, Charles David Weaver, Douglas J. Sheffler
This Letter describes the synthesis and SAR, developed through an iterative analogue library approach, of a novel series of selective M1 mAChR antagonists for the potential treatment of Parkinson's disease, dystonia and other movement disorders. Comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7551f8836883387c249a775ab62ad116
https://europepmc.org/articles/PMC2275053/
https://europepmc.org/articles/PMC2275053/
