Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Matthew J. Meier"'
Autor:
Marc A. Beal, Matthew J. Meier, Angela Dykes, Carole L. Yauk, Iain B. Lambert, Francesco Marchetti
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108407- (2023)
Summary: The lacZ gene of Escherichia coli encodes β-galactosidase (β-gal), a lactose metabolism enzyme of the lactose operon. Previous chemical modification or site-directed mutagenesis experiments have identified 21 amino acids that are essential
Externí odkaz:
https://doaj.org/article/82d55d46550040ffb5076b89459ea282
Publikováno v:
Data in Brief, Vol 48, Iss , Pp 109097- (2023)
The Syrian hamster (SH) is an animal model used in virology, toxicology, and carcinogenesis, where a better understanding of epigenetic mechanisms is required. Finding genetic loci regulated by DNA methylation may assist in the development of DNA met
Externí odkaz:
https://doaj.org/article/2122a64340ab47c8a36d45acc06fbfbe
Autor:
Anthony J. F. Reardon, Reza Farmahin, Andrew Williams, Matthew J. Meier, Gregory C. Addicks, Carole L. Yauk, Geronimo Matteo, Ella Atlas, Joshua Harrill, Logan J. Everett, Imran Shah, Richard Judson, Sreenivasa Ramaiahgari, Stephen S. Ferguson, Tara S. Barton-Maclaren
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
The growing number of chemicals in the current consumer and industrial markets presents a major challenge for regulatory programs faced with the need to assess the potential risks they pose to human and ecological health. The increasing demand for ha
Externí odkaz:
https://doaj.org/article/96854b10d2a34e91b4c5508eac32b91d
Autor:
Anne-Marie V. Fortin, Alexandra S. Long, Andrew Williams, Matthew J. Meier, Julie Cox, Claire Pinsonnault, Carole L. Yauk, Paul A. White
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
The conventional battery for genotoxicity testing is not well suited to assessing the large number of chemicals needing evaluation. Traditional in vitro tests lack throughput, provide little mechanistic information, and have poor specificity in predi
Externí odkaz:
https://doaj.org/article/a68fe45b28464a00be823488f906be56
Autor:
Julie K. Buick, Andrew Williams, Matthew J. Meier, Carol D. Swartz, Leslie Recio, Rémi Gagné, Stephen S. Ferguson, Bevin P. Engelward, Carole L. Yauk
Publikováno v:
Frontiers in Public Health, Vol 9 (2021)
Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical evaluation for human health risk assessment. In this study, we combined the high-throughput alkaline DNA damage-sensing CometChip® assay with the TGx-DDI
Externí odkaz:
https://doaj.org/article/e4d39a8558a149fc9ffab87e469ad97d
Autor:
Ajith Dias Samarajeewa, Jessica R. Velicogna, Dina M. Schwertfeger, Matthew J. Meier, Renuka M. Subasinghe, Juliska I. Princz, Rick P. Scroggins, Lee A. Beaudette
Publikováno v:
Environmental Science and Pollution Research.
Autor:
Annette E. Dodge, Danielle P.M. LeBlanc, Gu Zhou, Andrew Williams, Matthew J. Meier, Phu Van, Fang Yin Lo, Charles C. Valentine, Jesse J. Salk, Carole L. Yauk, Francesco Marchetti
Mutagenicity testing is an essential component of health safety assessment. Duplex Sequencing (DS), an emerging high-accuracy DNA sequencing technology, may provide substantial advantages over conventional mutagenicity assays. DS could be used to eli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a4e9772eacd5c77795f6b1185552eff
https://doi.org/10.1101/2023.02.23.529719
https://doi.org/10.1101/2023.02.23.529719
Autor:
Richard Carrier, Byron Kuo, Andrew Williams, Karen Leingartner, Julie Bourdon-Lacombe, Ella Atlas, Andrea Rowan-Carroll, Andy Nong, Rémi Gagné, Ivy Moffat, Carole L. Yauk, Stephen S. Ferguson, Luigi Lorusso, Matthew J. Meier, A. Reardon
Publikováno v:
Toxicological Sciences. 181:199-214
Per- and poly-fluoroalkyl substances (PFAS) are widely found in the environment because of their extensive use and persistence. Although several PFAS are well studied, most lack toxicity data to inform human health hazard and risk assessment. This st
Autor:
Daniel Desaulniers, Cathy Cummings-Lorbetskie, Karen Leingartner, Matthew J. Meier, Jessica C. Pickles, Carole L. Yauk
Publikováno v:
Toxicology. 487:153451
Autor:
Carole L. Yauk, Francesco Marchetti, Danielle P. LeBlanc, Clotilde Maurice, Jason M. O'Brien, Matthew J. Meier, Marc A. Beal
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Communications Biology
Communications Biology
Transgenic rodent (TGR) models use bacterial reporter genes to quantify in vivo mutagenesis. Pairing TGR assays with next-generation sequencing (NGS) enables comprehensive mutation pattern analysis to inform mutational mechanisms. We used this approa