Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Matthew J. M. Rowan"'
Autor:
Prateek Kumar, Annie M. Goettemoeller, Claudia Espinosa-Garcia, Brendan R. Tobin, Ali Tfaily, Ruth S. Nelson, Aditya Natu, Eric B. Dammer, Juliet V. Santiago, Sneha Malepati, Lihong Cheng, Hailian Xiao, Duc D. Duong, Nicholas T. Seyfried, Levi B. Wood, Matthew J. M. Rowan, Srikant Rangaraju
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-26 (2024)
Abstract Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally
Externí odkaz:
https://doaj.org/article/4a3d7575d66340e7b52ba0e5a848ab2b
Autor:
Mighten C. Yip, Mercedes M. Gonzalez, Christopher R. Valenta, Matthew J. M. Rowan, Craig R. Forest
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract A common electrophysiology technique used in neuroscience is patch clamp: a method in which a glass pipette electrode facilitates single cell electrical recordings from neurons. Typically, patch clamp is done manually in which an electrophys
Externí odkaz:
https://doaj.org/article/5db4cc70703448f39ca1561315d11c2a
Publikováno v:
eLife, Vol 7 (2018)
Motor learning involves neural circuit modifications in the cerebellar cortex, likely through re-weighting of parallel fiber inputs onto Purkinje cells (PCs). Climbing fibers instruct these synaptic modifications when they excite PCs in conjunction w
Externí odkaz:
https://doaj.org/article/f939885e8b6644f88526190d9d3d688c
Autor:
Erica Werner, David A. Lewis, Carrie E. Bearden, Meghan E. Wynne, Nicholas T. Seyfried, Zhexing Wen, Nicole Shearing, Oluwaseun B. Ogunbona, Avanti Gokhale, Julia L. Bassell, Duc M. Duong, Jill R. Glausier, Matthew J. M. Rowan, Chongchong Xu, Viktor János Oláh, Amanda A. H. Freeman, Chelsea E. Lee, Stephanie A. Zlatic, Cortnie Hartwig, Victor Faundez
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 41, iss 31
J Neurosci
J Neurosci
Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse development, neurotransmission, and are causative of neurodevelopmenta
Autor:
Christopher R. Valenta, Craig R. Forest, Matthew J M Rowan, Mercedes M. Gonzalez, Mighten C Yip
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
A common electrophysiology technique used in neuroscience is patch clamp: a method in which a glass pipette electrode facilitates single cell electrical recordings from neurons. Typically, patch clamp is done manually in which an electrophysiologist
Autor:
Samantha B Amat, Matthew J M Rowan, Michael A Gaffield, Audrey Bonnan, Chikako Kikuchi, Hiroki Taniguchi, Jason M Christie
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179347 (2017)
The cerebellar system helps modulate and fine-tune motor action. Purkinje cells (PCs) provide the sole output of the cerebellar cortex, therefore, any cerebellar involvement in motor activity must be driven by changes in PC firing rates. Several diff
Externí odkaz:
https://doaj.org/article/5a5971fc0bb9471b9ba326a726830076
Autor:
Viktor J, Olah, Annie M, Goettemoeller, Sruti, Rayaprolu, Eric B, Dammer, Nicholas T, Seyfried, Srikant, Rangaraju, Jordane, Dimidschstein, Matthew J M, Rowan
Publikováno v:
eLife. 11
In Alzheimer's disease (AD), a multitude of genetic risk factors and early biomarkers are known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD remain controversial. Toxic plaques and tangles correlate with progre
Autor:
Hirokazu Hirai, Michael A. Gaffield, Samantha B. Amat, Jason M. Christie, Matthew J. M. Rowan
Publikováno v:
eLife, Vol 7 (2018)
Motor learning involves neural circuit modifications in the cerebellar cortex, likely through re-weighting of parallel fiber inputs onto Purkinje cells (PCs). Climbing fibers instruct these synaptic modifications when they excite PCs in conjunction w
Autor:
Matthew J M, Rowan, Jason M, Christie
Publikováno v:
Cell reports. 18(8)
In many neurons, subthreshold depolarization in the soma can transiently increase action potential (AP)-evoked neurotransmission via analog-to-digital facilitation. The mechanisms underlying this form of short-term synaptic plasticity are unclear, in